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PRSS1
Gene Name
protease, serine, 1 (trypsin 1)
Image
Gene Ontology Annotations
Cellular Component
Extracellular Region
Extracellular Vesicular Exosome
Blood Microparticle
Molecular Function
Serine-type Endopeptidase Activity
Metal Ion Binding
Biological Process
Proteolysis
Vitamin Metabolic Process
Water-soluble Vitamin Metabolic Process
Digestion
Cobalamin Metabolic Process
Extracellular Matrix Disassembly
Extracellular Matrix Organization
Small Molecule Metabolic Process
Pathways
Metabolism of vitamins and cofactors
Defective CD320 causes methylmalonic aciduria
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF
Defective BTD causes biotidinase deficiency
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
Degradation of the extracellular matrix
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
Defective AMN causes hereditary megaloblastic anemia 1
Defects in cobalamin (B12) metabolism
Defective GIF causes intrinsic factor deficiency
Defective HLCS causes multiple carboxylase deficiency
Defective MMAB causes methylmalonic aciduria type cblB
Activation of Matrix Metalloproteinases
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD
Defective MMAA causes methylmalonic aciduria type cblA
Defective CUBN causes hereditary megaloblastic anemia 1
Cobalamin (Cbl, vitamin B12) transport and metabolism
Defective MUT causes methylmalonic aciduria mut type
Metabolism of water-soluble vitamins and cofactors
Defects in biotin (Btn) metabolism
Defective TCN2 causes hereditary megaloblastic anemia
Defects in vitamin and cofactor metabolism
Drugs
ZK-800270
Bis(5-Amidino-Benzimidazolyl)Methane
CRA_7806
Nalpha-(2-Naphthylsulfonylglycyl)-3-Amidino-D,L-Phenylalanine-Isopropylester
CRA_17693
N-Alpha-(2-Naphthylsulfonyl)-N(3-Amidino-L-Phenylalaninyl)Isopipecolinic Acid Methyl Ester
Hemi-Babim
CRA_10991
Monoisopropylphosphorylserine
[4-(6-Chloro-Naphthalene-2-Sulfonyl)-Piperazin-1-Yl]-(3,4,5,6-Tetrahydro-2h-[1,4\']Bipyridinyl-4-Yl)-Methanone
Bis(5-Amidino-2-Benzimidazolyl)Methanone
2-(2-Hydroxy-5-Methoxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine
5-Amidino-Benzimidazole
Amylamine
CRA_16847
Bis-Benzamidine
CRA_17312
Zk-806450
2-(2-Hydroxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine
[4-({[5-Benzyloxy-1-(3-Carbamimidoyl-Benzyl)-1h-Indole-2-Carbonyl]-Amino}-Methyl)-Phenyl]-Trimethyl-Ammonium
2-(2-Hydroxy-Phenyl)-3h-Benzoimidazole-5-Carboxamidine
CRA_9334
4-{[1-Methyl-5-(2-Methyl-Benzoimidazol-1-Ylmethyl)-1h-Benzoimidazol-2-Ylmethyl]-Amino}-Benzamidine
CRA_10762
Aminomethylcyclohexane
2-(2-Hydroxy-Phenyl)-1h-Indole-5-Carboxamidine
Benzylamine
CRA_10655
Trans-2-Phenylcyclopropylamine
RPR131247
Hexane
(2s,4r)-1-Acetyl-N-[(1s)-4-[(Aminoiminomethyl)Amino]-1-(2-Benzothiazolylcarbonyl)Butyl]-4-Hydroxy-2-Pyrrolidinecarboxamide
CRA_1802
CRA_10972
CRA_1801
Crc200 (Chiron-Behring)
Benzamidine
4-Iodobenzo[B]Thiophene-2-Carboxamidine
CRA_8696
CRA_10433
Bis(5-Amidino-2-Benzimidazolyl)Methane Ketone
4-Fluorobenzylamine
RWJ-51084
1-(2-Amidinophenyl)-3-(Phenoxyphenyl)Urea
ZK-806711
3,5-Diiodotyrosine
1-(4-Tert-Butylcarbamoyl-Piperazine-1-Carbonyl)-3-(3-Guanidino-Propyl)-4-Oxo-Azetidine-2-Carboxylic Acid
Bis(5-Amidino-Benzimidazolyl)Methanone Zinc
CRA_10950
CRA_11092
Cyclohexane
CRA_9785
Diminazene
CRA_1144
6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine
Thieno[2,3-B]Pyridine-2-Carboxamidine
Phosphorylisopropane
Bis(5-Amidino-Benzimidazolyl)Methane Zinc
[(1-{2[(4-Carbamimidoyl-Phenylamino)-Methyl]-1-Methyl-1h-Benzoimidazol-5-Yl}-Cyclopropyl)-Pyridin-2-Yl-Methyleneaminooxy]-Acetic Acid Ethyl Ester
N-Alpha-(2-Naphthylsulfonyl)-N(3-Amidino-L-Phenylalaninyl)-4-Acetyl-Piperazine
CRA_9076
N-Alpha-(2-Naphthylsulfonyl)-N-(3-Amidino-L-Phenylalaninyl)-D-Pipecolinic Acid
CRA_23653
Cyclotheonamide A
Bis(5-Amidino-2-Benzimidazolyl)Methane Ketone Hydrate
4-Phenylbutylamine
2-Phenylethylamine
1-(4-Amidinophenyl)-3-(4-Chlorophenyl)Urea
Aeruginosin 98-B
3-Phenylpropylamine
RPR128515
ZK-805623
2-(2-Oxo-1,2-Dihydro-Pyridin-3-Yl)-1h-Benzoimidazole-5-Carboxamidine
Benzo[B]Thiophene-2-Carboxamidine
CRA_10656
CRA_9678
4-PIPERIDIN-4-YLBUTANAL
2,5-bis-o-{3-[amino(imino)methyl]phenyl}-1,4:3,6-dianhydro-d-glucitol
2-O-(4\'-AMIDINOPHENYL)-5-O-(3\'\'-AMIDINOPHENYL)-1,4:3,6-DIANHYDRO-D-SORBITOL
2,5-O,O-BIS-{4\',4\'\'-AMIDINOPHENYL}-1,4:3,6-DIANHYDRO-D-SORBITOL
2-O-(3\'-AMIDINOPHENYL)-5-O-(4\'\'-AMIDINOPHENYL}-1,4:3,6-DIANHYDRO-D-SORBITOL
Aprotinin
diethyl [(1R)-1,5-diaminopentyl]boronate
(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentylamino)ethanoyl)pyrrolidine-2-carboxamide
(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexylamino)ethanoyl)pyrrolidine-2-carboxamide
N-cycloheptylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamide
N-cyclooctylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamide
2-(2-METHYLPHENYL)-1H-INDOLE-6-CARBOXIMIDAMIDE
2-(3-METHYLPHENYL)-1H-INDOLE-5-CARBOXIMIDAMIDE
(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentyloxy)ethanoyl)pyrrolidine-2-carboxamide
(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexyloxy)ethanoyl)pyrrolidine-2-carboxamide
(S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclopentylpropanoyl)pyrrolidine-2-carboxamide
(S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclohexylpropanoyl)pyrrolidine-2-carboxamide
3-{5-[AMINO(IMINIO)METHYL]-1H-INDOL-2-YL}-5-METHOXY-1,1\'-BIPHENYL-2-OLATE
4-(METHYLSULFONYL)BENZENECARBOXIMIDAMIDE
5-amino-2,4,6-tribromobenzene-1,3-dicarboxylic acid
+/-METHYL 4-(AMINOIMINOMETHYL)-BETA-[3- INH (AMINOIMINO)PHENYL]BENZENE PENTANOATE
2-(2-METHYLPHENYL)-1H-INDOLE-5-CARBOXIMIDAMIDE
2-NAPHTHALENESULFONIC ACID
1-{[1-(2-AMINO-3-PHENYL-PROPIONYL)-PYRROLIDINE-2-CARBONYL]-AMINO}-2-(3-CYANO-PHENYL)-ETHANEBORONIC ACID
[N-(BENZYLOXYCARBONYL)AMINO](4-AMIDINOPHENYL)METHANE-PHOSPHONATE
Diseases
GWAS
Pancreatitis (
23143602
)
Protein-protein Interactions
8 interactors:
DEFA5
PTPN4
SERPINA1
SERPINB13
SERPINB8
SERPINF2
SPINK5
TST
Entrez ID
5644
HPRD ID
02039
Ensembl ID
ENSG00000204983
Uniprot IDs
P07477
PDB IDs
1FXY
1TRN
2RA3
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Endopeptidase Activity
Negative Regulation Of Peptidase Activity
Negative Regulation Of Proteolysis
Negative Regulation Of Protein Processing
Regulation Of Endopeptidase Activity
Negative Regulation Of Hydrolase Activity
Regulation Of Protein Processing
Regulation Of Peptidase Activity
Regulation Of Proteolysis
Negative Regulation Of Serine-type Peptidase Activity
Negative Regulation Of Catalytic Activity
Negative Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Protein Metabolic Process
Acute-phase Response
Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Platelet Degranulation
Acute Inflammatory Response
Regulation Of Protein Metabolic Process
Response To Methanol
Anagen
Regulation Of Catalytic Activity
Cyanate Catabolic Process
Response To Triglyceride
RNA Import Into Mitochondrion
RRNA Import Into Mitochondrion
Response To Chromate
Regulation Of Blood Vessel Size By Renin-angiotensin
Sulfide Oxidation, Using Sulfide:quinone Oxidoreductase
Platelet Activation
Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Negative Regulation Of Serine-type Endopeptidase Activity
RRNA Transport
Negative Regulation Of Plasminogen Activation
Hair Follicle Maturation
Negative Regulation Of Fibrinolysis
Regulation Of Fibrinolysis
Sulfur Amino Acid Catabolic Process
Exocytosis
Extracellular Matrix Organization
Extracellular Structure Organization
Regulation Of Cell-cell Adhesion
Positive Regulation Of Transforming Growth Factor Beta Production
Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin
Defense Response
Inflammatory Response
Blood Coagulation
Hemostasis
Killing Of Cells Of Other Organism
Positive Regulation Of Collagen Biosynthetic Process
Tagcloud
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apc
april
atm
august
brca1
brca2
cdkn2a
consenting
custom
eleven
enrolls
estimates
germline
mlh1
msh2
msh6
ontario
palb2
pancreas
pancreatic
panel
pms2
precision
predisposition
proband
probands
province
stk11
strata