PRSS1 and TST

Number of citations of the paper that reports this interaction (PMID 8340386)
1

Data Source:
HPRD (in vitro)

		PRSS1	TST
Gene Name		protease, serine, 1 (trypsin 1)	thiosulfate sulfurtransferase (rhodanese)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Vesicular Exosome Blood Microparticle	Extracellular Space Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Metal Ion Binding	Thiosulfate Sulfurtransferase Activity 5S RRNA Binding
	Biological Process	Proteolysis Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Digestion Cobalamin Metabolic Process Extracellular Matrix Disassembly Extracellular Matrix Organization Small Molecule Metabolic Process	Sulfur Amino Acid Metabolic Process Sulfur Amino Acid Catabolic Process Cyanate Catabolic Process Epithelial Cell Differentiation Cellular Nitrogen Compound Metabolic Process RRNA Import Into Mitochondrion Small Molecule Metabolic Process RRNA Transport Sulfide Oxidation, Using Sulfide:quinone Oxidoreductase
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Degradation of the extracellular matrix Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective AMN causes hereditary megaloblastic anemia 1 Defects in cobalamin (B12) metabolism Defective GIF causes intrinsic factor deficiency Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Activation of Matrix Metalloproteinases Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Cobalamin (Cbl, vitamin B12) transport and metabolism Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism	Sulfide oxidation to sulfate Degradation of cysteine and homocysteine Sulfur amino acid metabolism Metabolism of amino acids and derivatives
Drugs		ZK-800270 Bis(5-Amidino-Benzimidazolyl)Methane CRA_7806 Nalpha-(2-Naphthylsulfonylglycyl)-3-Amidino-D,L-Phenylalanine-Isopropylester CRA_17693 N-Alpha-(2-Naphthylsulfonyl)-N(3-Amidino-L-Phenylalaninyl)Isopipecolinic Acid Methyl Ester Hemi-Babim CRA_10991 Monoisopropylphosphorylserine [4-(6-Chloro-Naphthalene-2-Sulfonyl)-Piperazin-1-Yl]-(3,4,5,6-Tetrahydro-2h-[1,4\']Bipyridinyl-4-Yl)-Methanone Bis(5-Amidino-2-Benzimidazolyl)Methanone 2-(2-Hydroxy-5-Methoxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine 5-Amidino-Benzimidazole Amylamine CRA_16847 Bis-Benzamidine CRA_17312 Zk-806450 2-(2-Hydroxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine [4-({[5-Benzyloxy-1-(3-Carbamimidoyl-Benzyl)-1h-Indole-2-Carbonyl]-Amino}-Methyl)-Phenyl]-Trimethyl-Ammonium 2-(2-Hydroxy-Phenyl)-3h-Benzoimidazole-5-Carboxamidine CRA_9334 4-{[1-Methyl-5-(2-Methyl-Benzoimidazol-1-Ylmethyl)-1h-Benzoimidazol-2-Ylmethyl]-Amino}-Benzamidine CRA_10762 Aminomethylcyclohexane 2-(2-Hydroxy-Phenyl)-1h-Indole-5-Carboxamidine Benzylamine CRA_10655 Trans-2-Phenylcyclopropylamine RPR131247 Hexane (2s,4r)-1-Acetyl-N-[(1s)-4-[(Aminoiminomethyl)Amino]-1-(2-Benzothiazolylcarbonyl)Butyl]-4-Hydroxy-2-Pyrrolidinecarboxamide CRA_1802 CRA_10972 CRA_1801 Crc200 (Chiron-Behring) Benzamidine 4-Iodobenzo[B]Thiophene-2-Carboxamidine CRA_8696 CRA_10433 Bis(5-Amidino-2-Benzimidazolyl)Methane Ketone 4-Fluorobenzylamine RWJ-51084 1-(2-Amidinophenyl)-3-(Phenoxyphenyl)Urea ZK-806711 3,5-Diiodotyrosine 1-(4-Tert-Butylcarbamoyl-Piperazine-1-Carbonyl)-3-(3-Guanidino-Propyl)-4-Oxo-Azetidine-2-Carboxylic Acid Bis(5-Amidino-Benzimidazolyl)Methanone Zinc CRA_10950 CRA_11092 Cyclohexane CRA_9785 Diminazene CRA_1144 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine Thieno[2,3-B]Pyridine-2-Carboxamidine Phosphorylisopropane Bis(5-Amidino-Benzimidazolyl)Methane Zinc [(1-{2[(4-Carbamimidoyl-Phenylamino)-Methyl]-1-Methyl-1h-Benzoimidazol-5-Yl}-Cyclopropyl)-Pyridin-2-Yl-Methyleneaminooxy]-Acetic Acid Ethyl Ester N-Alpha-(2-Naphthylsulfonyl)-N(3-Amidino-L-Phenylalaninyl)-4-Acetyl-Piperazine CRA_9076 N-Alpha-(2-Naphthylsulfonyl)-N-(3-Amidino-L-Phenylalaninyl)-D-Pipecolinic Acid CRA_23653 Cyclotheonamide A Bis(5-Amidino-2-Benzimidazolyl)Methane Ketone Hydrate 4-Phenylbutylamine 2-Phenylethylamine 1-(4-Amidinophenyl)-3-(4-Chlorophenyl)Urea Aeruginosin 98-B 3-Phenylpropylamine RPR128515 ZK-805623 2-(2-Oxo-1,2-Dihydro-Pyridin-3-Yl)-1h-Benzoimidazole-5-Carboxamidine Benzo[B]Thiophene-2-Carboxamidine CRA_10656 CRA_9678 4-PIPERIDIN-4-YLBUTANAL 2,5-bis-o-{3-[amino(imino)methyl]phenyl}-1,4:3,6-dianhydro-d-glucitol 2-O-(4\'-AMIDINOPHENYL)-5-O-(3\'\'-AMIDINOPHENYL)-1,4:3,6-DIANHYDRO-D-SORBITOL 2,5-O,O-BIS-{4\',4\'\'-AMIDINOPHENYL}-1,4:3,6-DIANHYDRO-D-SORBITOL 2-O-(3\'-AMIDINOPHENYL)-5-O-(4\'\'-AMIDINOPHENYL}-1,4:3,6-DIANHYDRO-D-SORBITOL Aprotinin diethyl [(1R)-1,5-diaminopentyl]boronate (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentylamino)ethanoyl)pyrrolidine-2-carboxamide (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexylamino)ethanoyl)pyrrolidine-2-carboxamide N-cycloheptylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamide N-cyclooctylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamide 2-(2-METHYLPHENYL)-1H-INDOLE-6-CARBOXIMIDAMIDE 2-(3-METHYLPHENYL)-1H-INDOLE-5-CARBOXIMIDAMIDE (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentyloxy)ethanoyl)pyrrolidine-2-carboxamide (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexyloxy)ethanoyl)pyrrolidine-2-carboxamide (S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclopentylpropanoyl)pyrrolidine-2-carboxamide (S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclohexylpropanoyl)pyrrolidine-2-carboxamide 3-{5-[AMINO(IMINIO)METHYL]-1H-INDOL-2-YL}-5-METHOXY-1,1\'-BIPHENYL-2-OLATE 4-(METHYLSULFONYL)BENZENECARBOXIMIDAMIDE 5-amino-2,4,6-tribromobenzene-1,3-dicarboxylic acid +/-METHYL 4-(AMINOIMINOMETHYL)-BETA-[3- INH (AMINOIMINO)PHENYL]BENZENE PENTANOATE 2-(2-METHYLPHENYL)-1H-INDOLE-5-CARBOXIMIDAMIDE 2-NAPHTHALENESULFONIC ACID 1-{[1-(2-AMINO-3-PHENYL-PROPIONYL)-PYRROLIDINE-2-CARBONYL]-AMINO}-2-(3-CYANO-PHENYL)-ETHANEBORONIC ACID [N-(BENZYLOXYCARBONYL)AMINO](4-AMIDINOPHENYL)METHANE-PHOSPHONATE
Diseases
GWAS		Pancreatitis ( 23143602)
Protein-Protein Interactions		8 interactors: DEFA5 PTPN4 SERPINA1 SERPINB13 SERPINB8 SERPINF2 SPINK5 TST	2 interactors: ND1 PRSS1
Entrez ID		5644	7263
HPRD ID		02039	01583
Ensembl ID		ENSG00000204983	ENSG00000128311
Uniprot IDs		P07477	Q16762
PDB IDs		1FXY 1TRN 2RA3
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Regulation Of Proteolysis Negative Regulation Of Serine-type Peptidase Activity Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Acute-phase Response Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Platelet Degranulation Acute Inflammatory Response Regulation Of Protein Metabolic Process Response To Methanol Anagen Regulation Of Catalytic Activity Cyanate Catabolic Process Response To Triglyceride RNA Import Into Mitochondrion RRNA Import Into Mitochondrion Response To Chromate Regulation Of Blood Vessel Size By Renin-angiotensin Sulfide Oxidation, Using Sulfide:quinone Oxidoreductase Platelet Activation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Serine-type Endopeptidase Activity RRNA Transport Negative Regulation Of Plasminogen Activation Hair Follicle Maturation Negative Regulation Of Fibrinolysis Regulation Of Fibrinolysis Sulfur Amino Acid Catabolic Process Exocytosis Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Cell-cell Adhesion Positive Regulation Of Transforming Growth Factor Beta Production Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Defense Response Inflammatory Response Blood Coagulation Hemostasis Killing Of Cells Of Other Organism Positive Regulation Of Collagen Biosynthetic Process	Cobalamin Metabolic Process Mitochondrial Electron Transport, NADH To Ubiquinone Mitochondrial ATP Synthesis Coupled Electron Transport Oxidative Phosphorylation Tetrapyrrole Metabolic Process Water-soluble Vitamin Metabolic Process Extracellular Matrix Disassembly Respiratory Electron Transport Chain Vitamin Metabolic Process Digestion Small Molecule Metabolic Process Electron Transport Chain ATP Metabolic Process Cellular Respiration Purine Nucleoside Metabolic Process Ribonucleotide Metabolic Process Nucleoside Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Purine Nucleotide Metabolic Process Ribose Phosphate Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization
Tagcloud ?		apc april atm august brca1 brca2 cdkn2a consenting custom eleven enrolls estimates germline mlh1 msh2 msh6 ontario palb2 pancreas pancreatic panel pms2 precision predisposition proband probands province stk11 strata	apnoea aspect borderline diurnal epworth ess exclude hypersomnolence hypopnoea interchangeable msl mslt narcolepsy obstructive osa overnight periodic polysomnography psychoticism rem rhythm sleep sleepiness snoring somatisation spearman subscale subscales tendency
Tagcloud (Difference) ?		apc april atm august brca1 brca2 cdkn2a consenting custom eleven enrolls estimates germline mlh1 msh2 msh6 ontario palb2 pancreas pancreatic panel pms2 precision predisposition proband probands province stk11 strata	apnoea aspect borderline diurnal epworth ess exclude hypersomnolence hypopnoea interchangeable msl mslt narcolepsy obstructive osa overnight periodic polysomnography psychoticism rem rhythm sleep sleepiness snoring somatisation spearman subscale subscales tendency
Tagcloud (Intersection) ?