SPINK5 and PRSS1

Number of citations of the paper that reports this interaction (PMID 10419450)
22

Data Source:
HPRD (in vitro)

		SPINK5	PRSS1
Gene Name		serine peptidase inhibitor, Kazal type 5	protease, serine, 1 (trypsin 1)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Cell Cortex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Epidermal Lamellar Body	Extracellular Region Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity	Serine-type Endopeptidase Activity Metal Ion Binding
	Biological Process	Epidermal Cell Differentiation Negative Regulation Of Endopeptidase Activity Negative Regulation Of Angiogenesis Extracellular Matrix Organization Epithelial Cell Differentiation Hair Cell Differentiation Anagen Regulation Of T Cell Differentiation Negative Regulation Of Immune Response Negative Regulation Of Serine-type Peptidase Activity	Proteolysis Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Digestion Cobalamin Metabolic Process Extracellular Matrix Disassembly Extracellular Matrix Organization Small Molecule Metabolic Process
Pathways			Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Degradation of the extracellular matrix Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective AMN causes hereditary megaloblastic anemia 1 Defects in cobalamin (B12) metabolism Defective GIF causes intrinsic factor deficiency Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Activation of Matrix Metalloproteinases Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Cobalamin (Cbl, vitamin B12) transport and metabolism Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism
Drugs			ZK-800270 Bis(5-Amidino-Benzimidazolyl)Methane CRA_7806 Nalpha-(2-Naphthylsulfonylglycyl)-3-Amidino-D,L-Phenylalanine-Isopropylester CRA_17693 N-Alpha-(2-Naphthylsulfonyl)-N(3-Amidino-L-Phenylalaninyl)Isopipecolinic Acid Methyl Ester Hemi-Babim CRA_10991 Monoisopropylphosphorylserine [4-(6-Chloro-Naphthalene-2-Sulfonyl)-Piperazin-1-Yl]-(3,4,5,6-Tetrahydro-2h-[1,4\']Bipyridinyl-4-Yl)-Methanone Bis(5-Amidino-2-Benzimidazolyl)Methanone 2-(2-Hydroxy-5-Methoxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine 5-Amidino-Benzimidazole Amylamine CRA_16847 Bis-Benzamidine CRA_17312 Zk-806450 2-(2-Hydroxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine [4-({[5-Benzyloxy-1-(3-Carbamimidoyl-Benzyl)-1h-Indole-2-Carbonyl]-Amino}-Methyl)-Phenyl]-Trimethyl-Ammonium 2-(2-Hydroxy-Phenyl)-3h-Benzoimidazole-5-Carboxamidine CRA_9334 4-{[1-Methyl-5-(2-Methyl-Benzoimidazol-1-Ylmethyl)-1h-Benzoimidazol-2-Ylmethyl]-Amino}-Benzamidine CRA_10762 Aminomethylcyclohexane 2-(2-Hydroxy-Phenyl)-1h-Indole-5-Carboxamidine Benzylamine CRA_10655 Trans-2-Phenylcyclopropylamine RPR131247 Hexane (2s,4r)-1-Acetyl-N-[(1s)-4-[(Aminoiminomethyl)Amino]-1-(2-Benzothiazolylcarbonyl)Butyl]-4-Hydroxy-2-Pyrrolidinecarboxamide CRA_1802 CRA_10972 CRA_1801 Crc200 (Chiron-Behring) Benzamidine 4-Iodobenzo[B]Thiophene-2-Carboxamidine CRA_8696 CRA_10433 Bis(5-Amidino-2-Benzimidazolyl)Methane Ketone 4-Fluorobenzylamine RWJ-51084 1-(2-Amidinophenyl)-3-(Phenoxyphenyl)Urea ZK-806711 3,5-Diiodotyrosine 1-(4-Tert-Butylcarbamoyl-Piperazine-1-Carbonyl)-3-(3-Guanidino-Propyl)-4-Oxo-Azetidine-2-Carboxylic Acid Bis(5-Amidino-Benzimidazolyl)Methanone Zinc CRA_10950 CRA_11092 Cyclohexane CRA_9785 Diminazene CRA_1144 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine Thieno[2,3-B]Pyridine-2-Carboxamidine Phosphorylisopropane Bis(5-Amidino-Benzimidazolyl)Methane Zinc [(1-{2[(4-Carbamimidoyl-Phenylamino)-Methyl]-1-Methyl-1h-Benzoimidazol-5-Yl}-Cyclopropyl)-Pyridin-2-Yl-Methyleneaminooxy]-Acetic Acid Ethyl Ester N-Alpha-(2-Naphthylsulfonyl)-N(3-Amidino-L-Phenylalaninyl)-4-Acetyl-Piperazine CRA_9076 N-Alpha-(2-Naphthylsulfonyl)-N-(3-Amidino-L-Phenylalaninyl)-D-Pipecolinic Acid CRA_23653 Cyclotheonamide A Bis(5-Amidino-2-Benzimidazolyl)Methane Ketone Hydrate 4-Phenylbutylamine 2-Phenylethylamine 1-(4-Amidinophenyl)-3-(4-Chlorophenyl)Urea Aeruginosin 98-B 3-Phenylpropylamine RPR128515 ZK-805623 2-(2-Oxo-1,2-Dihydro-Pyridin-3-Yl)-1h-Benzoimidazole-5-Carboxamidine Benzo[B]Thiophene-2-Carboxamidine CRA_10656 CRA_9678 4-PIPERIDIN-4-YLBUTANAL 2,5-bis-o-{3-[amino(imino)methyl]phenyl}-1,4:3,6-dianhydro-d-glucitol 2-O-(4\'-AMIDINOPHENYL)-5-O-(3\'\'-AMIDINOPHENYL)-1,4:3,6-DIANHYDRO-D-SORBITOL 2,5-O,O-BIS-{4\',4\'\'-AMIDINOPHENYL}-1,4:3,6-DIANHYDRO-D-SORBITOL 2-O-(3\'-AMIDINOPHENYL)-5-O-(4\'\'-AMIDINOPHENYL}-1,4:3,6-DIANHYDRO-D-SORBITOL Aprotinin diethyl [(1R)-1,5-diaminopentyl]boronate (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentylamino)ethanoyl)pyrrolidine-2-carboxamide (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexylamino)ethanoyl)pyrrolidine-2-carboxamide N-cycloheptylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamide N-cyclooctylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamide 2-(2-METHYLPHENYL)-1H-INDOLE-6-CARBOXIMIDAMIDE 2-(3-METHYLPHENYL)-1H-INDOLE-5-CARBOXIMIDAMIDE (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentyloxy)ethanoyl)pyrrolidine-2-carboxamide (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexyloxy)ethanoyl)pyrrolidine-2-carboxamide (S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclopentylpropanoyl)pyrrolidine-2-carboxamide (S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclohexylpropanoyl)pyrrolidine-2-carboxamide 3-{5-[AMINO(IMINIO)METHYL]-1H-INDOL-2-YL}-5-METHOXY-1,1\'-BIPHENYL-2-OLATE 4-(METHYLSULFONYL)BENZENECARBOXIMIDAMIDE 5-amino-2,4,6-tribromobenzene-1,3-dicarboxylic acid +/-METHYL 4-(AMINOIMINOMETHYL)-BETA-[3- INH (AMINOIMINO)PHENYL]BENZENE PENTANOATE 2-(2-METHYLPHENYL)-1H-INDOLE-5-CARBOXIMIDAMIDE 2-NAPHTHALENESULFONIC ACID 1-{[1-(2-AMINO-3-PHENYL-PROPIONYL)-PYRROLIDINE-2-CARBONYL]-AMINO}-2-(3-CYANO-PHENYL)-ETHANEBORONIC ACID [N-(BENZYLOXYCARBONYL)AMINO](4-AMIDINOPHENYL)METHANE-PHOSPHONATE
Diseases
GWAS			Pancreatitis ( 23143602)
Protein-Protein Interactions		1 interactors: PRSS1	8 interactors: DEFA5 PTPN4 SERPINA1 SERPINB13 SERPINB8 SERPINF2 SPINK5 TST
Entrez ID		11005	5644
HPRD ID		05423	02039
Ensembl ID		ENSG00000133710	ENSG00000204983
Uniprot IDs		Q9NQ38	P07477
PDB IDs		1H0Z 1HDL 1UUC 1UVF 1UVG	1FXY 1TRN 2RA3
Enriched GO Terms of Interacting Partners?		Cobalamin Metabolic Process Tetrapyrrole Metabolic Process Water-soluble Vitamin Metabolic Process Extracellular Matrix Disassembly Vitamin Metabolic Process Digestion	Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Regulation Of Proteolysis Negative Regulation Of Serine-type Peptidase Activity Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Acute-phase Response Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Platelet Degranulation Acute Inflammatory Response Regulation Of Protein Metabolic Process Response To Methanol Anagen Regulation Of Catalytic Activity Cyanate Catabolic Process Response To Triglyceride RNA Import Into Mitochondrion RRNA Import Into Mitochondrion Response To Chromate Regulation Of Blood Vessel Size By Renin-angiotensin Sulfide Oxidation, Using Sulfide:quinone Oxidoreductase Platelet Activation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Serine-type Endopeptidase Activity RRNA Transport Negative Regulation Of Plasminogen Activation Hair Follicle Maturation Negative Regulation Of Fibrinolysis Regulation Of Fibrinolysis Sulfur Amino Acid Catabolic Process Exocytosis Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Cell-cell Adhesion Positive Regulation Of Transforming Growth Factor Beta Production Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Defense Response Inflammatory Response Blood Coagulation Hemostasis Killing Of Cells Of Other Organism Positive Regulation Of Collagen Biosynthetic Process
Tagcloud ?		chymotrypsin corneodesmosomes corneum desmocollin desmoglein detached dsc1 dsg1 filaggrin gels kallikreins kazal klk5 klk7 knockdowns lekti lympho netherton omim organotypic parakeratotic populated recapitulates scce scte stratum therapeutically thicker transfecting	apc april atm august brca1 brca2 cdkn2a consenting custom eleven enrolls estimates germline mlh1 msh2 msh6 ontario palb2 pancreas pancreatic panel pms2 precision predisposition proband probands province stk11 strata
Tagcloud (Difference) ?		chymotrypsin corneodesmosomes corneum desmocollin desmoglein detached dsc1 dsg1 filaggrin gels kallikreins kazal klk5 klk7 knockdowns lekti lympho netherton omim organotypic parakeratotic populated recapitulates scce scte stratum therapeutically thicker transfecting	apc april atm august brca1 brca2 cdkn2a consenting custom eleven enrolls estimates germline mlh1 msh2 msh6 ontario palb2 pancreas pancreatic panel pms2 precision predisposition proband probands province stk11 strata
Tagcloud (Intersection) ?