METTL3 and MTDH

Number of citations of the paper that reports this interaction (PubMedID 22199357)
32

Data Source:
BioGRID (unspecified method)

		METTL3	MTDH
Description		methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	metadherin
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Nuclear Body Nuclear Speck RNA N6-methyladenosine Methyltransferase Complex Oxidoreductase Complex	Fibrillar Center Nucleus Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Bicellular Tight Junction Membrane Apical Plasma Membrane Nuclear Body Nuclear Membrane Intercellular Canaliculus Perinuclear Region Of Cytoplasm Anchoring Junction
	Molecular Function	MRNA M(6)A Methyltransferase Activity RNA Binding MRNA Binding Protein Binding Methyltransferase Activity RNA Methyltransferase Activity Transferase Activity Protein Heterodimerization Activity S-adenosyl-L-methionine Binding	Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding Double-stranded RNA Binding Protein Binding NF-kappaB Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	MRNA Splicing, Via Spliceosome RNA Methylation Immune System Process MRNA Processing MRNA Export From Nucleus DNA Damage Response Spermatogenesis Circadian Rhythm Dosage Compensation By Inactivation Of X Chromosome MRNA Modification Stem Cell Population Maintenance Forebrain Radial Glial Cell Differentiation Cell Differentiation Primary MiRNA Processing Methylation Cellular Response To UV Gliogenesis Innate Immune Response Regulation Of T Cell Differentiation Positive Regulation Of Translation Negative Regulation Of Notch Signaling Pathway Oogenesis Rhythmic Process Regulation Of Meiotic Cell Cycle Negative Regulation Of Type I Interferon-mediated Signaling Pathway MRNA Destabilization Endothelial To Hematopoietic Transition Regulation Of Hematopoietic Stem Cell Differentiation Positive Regulation Of Cap-independent Translational Initiation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Autophagy Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Angiogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways		Processing of Capped Intron-Containing Pre-mRNA
Drugs
Diseases
GWAS		Response to Homoharringtonine (cytotoxicity) ( 25628645)	Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Migraine ( 20802479) Nicotine metabolite ratio in current smokers ( 27488534) Plasma parathyroid hormone levels ( 30134803) Red cell distribution width ( 27863252 28957414 32888494) Sweet taste preference ( 32572145)
Interacting Genes		9 interacting genes: EIF3G EIF3I EIF3J EIF3M MAPK1 MAPK14 MAPK8 MTDH USP5	175 interacting genes: ABCA12 ABCC3 ABTB1 ACTN1 ADCK2 ADGRA2 AGAP3 ALOX5 ANKRD13D ANKRD26P1 ANPEP ARNT2 ARRDC1 AXL BCAS3 BCS1L CAPN2 CARD8 CCL20 CCN2 CCNDBP1 CCT4 CD109 CD22 CDC14B CDC42 CEP162 CLCN7 CLDN2 CLMN COL13A1 COL4A4 COL6A1 CPAP CPT2 CRIM1 CSNK2A1 CTSB CUL7 CUL9 CYFIP2 CYP27A1 CYP4V2 DMTF1 DNAH5 DNAI4 DOCK2 DOP1B DSP DUSP5 ECE1 EGFR EGR1 ELN EML1 EPHB1 EPHX2 ERCC2 ERICH6B ESAM FAM184A FANCI FASN FCGRT FLNA FLNC FN1 FOXM1 GHDC GLG1 GRID1 HACE1 HERC5 HSPG2 ICA1L IFT46 IKBKB IL17RA IL2RB IPO9 IRS2 ITGB5 ITPR3 JADE3 JAG1 KCNH1 KCNQ5 KDM6A KMT2B LAMA5 LDLRAD2 LOXL4 LRIG3 LRP1 LRP5 MAP3K12 MCM6 MEGF11 METTL3 MLPH MMP2 MNT MRC2 MRPL39 MYH9 MYL5 NEB NEO1 NFKB2 NOTCH3 NPC1 NPR1 NUP210 NXF4 OBSCN OGT OR8G5 OSMR PCCB PCDH7 PKN1 PLAT PLD2 PLEC PLEKHO2 PLXNA3 PPFIA2 PRICKLE4 PSIP1 PTHLH PWP2 RAB24 RGS13 RIN1 RIPK1 RNF123 RNF213 RSPO3 RYR1 SDK1 SELENOI SEZ6L2 SGSM2 SH2B2 SIAE SLC38A4 SLC67A1-AS SPEF2 SPRED2 SPTBN5 SQSTM1 SSH3 STEAP3 STK25 STXBP1 SYNE1 TACR2 TBC1D2B TBCD TCIRG1 TEP1 THBS1 THSD4 TINAGL1 TNS2 TOPORS TRAPPC12 TRPC4AP TUBB3 UBXN7 VIM WDFY2 WNK2 ZNF559 ZXDC
Entrez ID		56339	92140
HPRD ID		14389	17459
Ensembl ID		ENSG00000165819	ENSG00000147649
Uniprot IDs		Q86U44	Q86UE4
PDB IDs		5IL0 5IL1 5IL2 5K7M 5K7U 5K7W 5L6D 5L6E 5TEY 5YZ9 6TTP 6TTT 6TTV 6TTW 6TTX 6TU1 6Y4G 7ACD 7NHG 7NHH 7NHI 7NHJ 7NHV 7NI7 7NI8 7NI9 7NIA 7NID 7O08 7O09 7O0L 7O0M 7O0P 7O0Q 7O0R 7O27 7O28 7O29 7O2E 7O2F 7O2H 7O2I 7O2X 7OED 7OEE 7OEF 7OEG 7OEH 7OEI 7OEJ 7OEK 7OEL 7OEM 7OQL 7OQO 7OQP 7RX6 7RX7 7RX8 8BN8 8PW8 8PW9 8PWA 8PWB 9G4S 9G4U 9G4W	4QMG
Enriched GO Terms of Interacting Partners?		Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Cytoplasmic Translational Initiation Translation Initiation Factor Activity MAP Kinase Activity Translational Initiation Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Lipopolysaccharide-mediated Signaling Pathway Protein-RNA Complex Assembly Protein Metabolic Process Eukaryotic Translation Initiation Factor 3 Complex, EIF3m Protein-containing Complex Assembly Protein-containing Complex Organization Translation Positive Regulation Of Cyclase Activity Peptidyl-threonine Phosphorylation Canonical Inflammasome Complex Assembly MAPK Cascade Macromolecule Metabolic Process Cytoplasm Macromolecule Biosynthetic Process Cellular Component Assembly Response To Lipopolysaccharide Cellular Senescence Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation JUN Phosphorylation Response To Molecule Of Bacterial Origin Cytosol Energy Homeostasis Protein Serine Kinase Activity Regulation Of Immune Response Protein Serine/threonine Kinase Activity Protein Phosphatase Binding Cytosine Metabolic Process Cellular Response To Tumor Necrosis Factor Regulation Of Synaptic Membrane Adhesion Interleukin-34-mediated Signaling Pathway JUN Kinase Activity Regulation Protein Catabolic Process At Presynapse Regulation Of Ossification Response To Nutrient Levels Ficolin-1-rich Granule Lumen Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Tumor Necrosis Factor Protein Kinase Activity Regulation Of Golgi Inheritance	Anatomical Structure Formation Involved In Morphogenesis Plasma Membrane Developmental Process Cell Adhesion Extracellular Exosome Cell Surface Receptor Signaling Pathway Angiogenesis Cell-cell Fusion Syncytium Formation Syncytium Formation By Plasma Membrane Fusion Receptor Complex Myoblast Fusion Regulation Of Cellular Component Organization Cell Migration Actin Cytoskeleton Organization Cytoskeleton Organization Extracellular Matrix Endodermal Cell Differentiation Actin Filament Binding Homotypic Cell-cell Adhesion Cell-cell Adhesion Z Disc Regulation Of Signaling Cell Motility Ameboidal-type Cell Migration Actin Filament-based Process Membrane Protein Maturation Collagen V Binding Organelle Organization Focal Adhesion Signal Transduction Integrin Binding Cell Morphogenesis Regulation Of Cell Communication Hair Cycle Process Regulation Of Actin Filament-based Process Anatomical Structure Morphogenesis Cytoskeleton Extracellular Matrix Structural Constituent Skin Development Virus Receptor Activity Cell-substrate Adhesion Golgi Organization Symbiont Entry Into Host Cell Tissue Remodeling Sarcomere Proteoglycan Binding Insulin-like Growth Factor Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway
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