ANKRD7 and MARK3

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		ANKRD7	MARK3
Description		ankyrin repeat domain 7	microtubule affinity regulating kinase 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Centrosome	Cytoplasm Cytosol Plasma Membrane Membrane Dendrite Cell Projection Extracellular Exosome
	Molecular Function		Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Phosphatase Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity
	Biological Process		Microtubule Cytoskeleton Organization Protein Phosphorylation Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Negative Regulation Of Protein Localization To Nucleus
Pathways			RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs			Fostamatinib
Diseases
GWAS		Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Heel bone mineral density ( 30598549) Heel bone mineral density x serum urate levels interaction ( 34046847) Pursuit maintenance gain ( 29064472)	Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301) Autism spectrum disorder or schizophrenia ( 28540026) Blond vs. brown/black hair color ( 30531825) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778 33020668) Cutaneous melanoma or hair colour ( 32341527) Femoral neck bone mineral density ( 22504420) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 28869591 30598549) Height ( 31562340) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 29403010 27863252) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Optic disc size ( 31809533) PR interval ( 32439900) Systolic blood pressure ( 30578418 30224653) Type 2 diabetes ( 30297969) White blood cell count ( 32888494)
Interacting Genes		2 interacting genes: HSPB1 MARK3	28 interacting genes: ANKRD7 ARHGEF2 ASB13 ATP6V0C CDC25C CHGB CLASP1 CPSF4 DYNLL1 FANCF FBXO7 HDAC7 KSR1 MAP2 MAPT MITF NOL11 PKP2 PMPCB PNPLA2 PRKCQ SAAL1 SFN TCEA2 TTR VPS11 YWHAG YWHAZ
Entrez ID		56311	4140
HPRD ID		12466	04058
Ensembl ID		ENSG00000106013	ENSG00000075413
Uniprot IDs		A0A140VJE5 Q92527	A0A7I2V2E3 A0A7I2V2N8 A0A7I2V3B9 A0A7I2V5G3 A0A7I2V639 A0A7I2YQF7 H0YNV4 P27448 Q86U11
PDB IDs			2QNJ 3FE3 7P1L 8UOH 8UOI 8UOJ 8UOK 8UOL
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Kinase C Signaling Regulation Of Protein Kinase C Signaling Positive Regulation Of Endothelial Cell Chemotaxis Protein Transport Along Microtubule Anterograde Axonal Protein Transport Protein Kinase C Inhibitor Activity Contractile Muscle Fiber Negative Regulation Of Intracellular Signal Transduction Microtubule-based Process Tau-protein Kinase Activity Negative Regulation Of Hippo Signaling Protein Refolding Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Signal Transduction Protein Localization To Synapse Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Blood Vessel Endothelial Cell Migration Protein Folding Chaperone Protein Kinase C Binding Platelet Aggregation Axon Cytoplasm Negative Regulation Of Cell Communication Positive Regulation Of Interleukin-1 Beta Production Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Axonal Transport Anterograde Axonal Transport Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Cornified Envelope Proteasome Complex Negative Regulation Of Signaling Homotypic Cell-cell Adhesion Regulation Of Hippo Signaling Tau Protein Binding Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Interleukin-1 Production	Protein Kinase C Inhibitor Activity Phosphoserine Residue Binding Main Axon Regulation Of Microtubule Polymerization Or Depolymerization Protein Sequestering Activity Negative Regulation Of Microtubule Polymerization Or Depolymerization Protein Kinase C Binding Regulation Of Phosphorylation Positive Regulation Of Intracellular Transport Dystroglycan Binding Protein Kinase Binding Tubulin Binding Regulation Of Microtubule Cytoskeleton Organization Regulation Of Microtubule Polymerization Phototransduction, Visible Light Regulation Of Cell Differentiation Microtubule
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