PRPH and KRT6A

Number of citations of the paper that reports this interaction (PubMedID 35575683)
0

Data Source:
BioGRID (cross-linking study)

		PRPH	KRT6A
Description		peripherin	keratin 6A
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Intermediate Filament Plasma Membrane Membrane Axon Cell Projection Perikaryon Type III Intermediate Filament Extracellular Exosome	Nucleus Cytosol Intermediate Filament Membrane Keratin Filament Extracellular Exosome
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding	Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Intermediate Filament Organization	Morphogenesis Of An Epithelium Positive Regulation Of Cell Population Proliferation Cell Differentiation Keratinization Killing Of Cells Of Another Organism Wound Healing Intermediate Filament Organization Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Negative Regulation Of Entry Of Bacterium Into Host Cell
Pathways			Keratinization Formation of the cornified envelope
Drugs			Zinc Zinc acetate
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease	Pachyonychia congenita, including: Jadassohn-Lewandowsky syndrome; Jackson-Lawler syndrome ; Steatocystoma multiplex
GWAS		Prostate cancer ( 21743467) Sural nerve amplitude potential ( 30992453)	Cutaneous squamous cell carcinoma ( 32041948)
Interacting Genes		34 interacting genes: CDC37 CT55 DDX6 DES FCHO1 INCA1 KIFC3 KRT14 KRT15 KRT16 KRT20 KRT24 KRT27 KRT31 LCA5L LENG1 LMNB1 LNX1 MAGOHB MYO5A NXF1 PIAS2 PPP1R13B PPP1R18 PRKAA2 PRPH2 PSMA1 TCEA2 TCP10L TTC23 VIM ZC4H2 ZMAT2 ZNF572	37 interacting genes: BEX2 CCDC85B DSP GEM GOLGA2 HGS KDM1A KIFC3 KRT13 KRT15 KRT17 KRT18 KRT19 KRT25 KRT26 KRT27 KRT28 KRT31 KRT34 KRT35 KRT36 KRT38 KRT40 LMNA MTUS2 NCALD NUP62 SGTA SMARCB1 TCHP TFIP11 TRIM23 TRIM54 TSGA10 TXLNB UBQLN2 WASHC3
Entrez ID		5630	3853
HPRD ID		01365	01011
Ensembl ID		ENSG00000135406	ENSG00000205420
Uniprot IDs		B3KWQ6 P41219	A0A0S2Z428 P02538
PDB IDs			5KI0
Enriched GO Terms of Interacting Partners?		Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Structural Constituent Of Skin Epidermis Structural Constituent Of Cytoskeleton Keratin Filament Supramolecular Fiber Organization Structural Molecule Activity Morphogenesis Of An Epithelium Tissue Morphogenesis Cytoskeleton Organization Epithelial Cell Differentiation Keratin Filament Binding Cytoskeleton Extracellular Exosome Intermediate Filament Cytoskeleton Epidermis Development Protein Binding Organelle Organization Hair Cycle Scaffold Protein Binding Cytoplasmic Stress Granule Nuclear Envelope Organization	Intermediate Filament Organization Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Structural Constituent Of Skin Epidermis Keratin Filament Intermediate Filament Structural Molecule Activity Supramolecular Fiber Organization Cytoskeleton Organization Epithelial Cell Differentiation Cytoskeleton Organelle Organization Tissue Morphogenesis Morphogenesis Of An Epithelium Structural Constituent Of Cytoskeleton Keratinization Extracellular Exosome Cellular Developmental Process Intermediate Filament Cytoskeleton Cell Differentiation Anatomical Structure Morphogenesis Hair Follicle Morphogenesis Epidermis Development Developmental Process Scaffold Protein Binding Cytosol Hair Cycle Process Protein Binding Adherens Junction Cornified Envelope Tissue Development Epithelial Cell-cell Adhesion Peptide Cross-linking Positive Regulation Of ERAD Pathway
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