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KRT6A and DSP
Number of citations of the paper that reports this interaction (PubMedID
7525601
)
43
Data Source:
HPRD
(in vitro)
KRT6A
DSP
Description
keratin 6A
desmoplakin
Image
GO Annotations
Cellular Component
Nucleus
Cytosol
Intermediate Filament
Membrane
Keratin Filament
Extracellular Exosome
Cornified Envelope
Nucleus
Cytoplasm
Cytoskeleton
Intermediate Filament
Plasma Membrane
Cell-cell Junction
Adherens Junction
Fascia Adherens
Intercalated Disc
Membrane
Basolateral Plasma Membrane
Desmosome
Extracellular Exosome
Anchoring Junction
Ficolin-1-rich Granule Membrane
Molecular Function
Structural Constituent Of Cytoskeleton
Protein Binding
Structural Constituent Of Skin Epidermis
RNA Binding
Protein Kinase C Binding
Structural Molecule Activity
Structural Constituent Of Cytoskeleton
Protein Binding
Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
Scaffold Protein Binding
Biological Process
Morphogenesis Of An Epithelium
Positive Regulation Of Cell Population Proliferation
Cell Differentiation
Keratinization
Killing Of Cells Of Another Organism
Wound Healing
Intermediate Filament Organization
Defense Response To Gram-positive Bacterium
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Negative Regulation Of Entry Of Bacterium Into Host Cell
Desmosome Organization
Ventricular Compact Myocardium Morphogenesis
Epidermis Development
Peptide Cross-linking
Keratinocyte Differentiation
Adherens Junction Organization
Wound Healing
Skin Development
Intermediate Filament Cytoskeleton Organization
Intermediate Filament Organization
Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication
Regulation Of Heart Rate By Cardiac Conduction
Epithelial Cell-cell Adhesion
Cell-cell Adhesion
Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Protein Localization To Cell-cell Junction
Pathways
Keratinization
Formation of the cornified envelope
Apoptotic cleavage of cell adhesion proteins
Neutrophil degranulation
Keratinization
Formation of the cornified envelope
RND3 GTPase cycle
RND1 GTPase cycle
Drugs
Zinc
Zinc acetate
Zinc
Artenimol
Zinc acetate
Diseases
Pachyonychia congenita, including: Jadassohn-Lewandowsky syndrome; Jackson-Lawler syndrome ; Steatocystoma multiplex
Striate palmoplantar keratoderma
Skin fragility-woolly hair syndrome
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Naxos disease and Carvajal syndrome
Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic
GWAS
Cutaneous squamous cell carcinoma (
32041948
)
Chronic obstructive pulmonary disease (
28166215
30804561
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Idiopathic pulmonary fibrosis (
29066090
31710517
)
Interstitial lung disease (
23583980
)
Lung function (FEV1/FVC) (
30804560
)
Lung function (FVC) (
30804560
)
Numerical cognitive ability (
31620175
)
PR interval (
32439900
)
Response to fenofibrate (triglyceride levels) (
27002377
)
Resting heart rate (
27798624
)
Interacting Genes
37 interacting genes:
BEX2
CCDC85B
DSP
GEM
GOLGA2
HGS
KDM1A
KIFC3
KRT13
KRT15
KRT17
KRT18
KRT19
KRT25
KRT26
KRT27
KRT28
KRT31
KRT34
KRT35
KRT36
KRT38
KRT40
LMNA
MTUS2
NCALD
NUP62
SGTA
SMARCB1
TCHP
TFIP11
TRIM23
TRIM54
TSGA10
TXLNB
UBQLN2
WASHC3
36 interacting genes:
ARID3A
CASP10
CASP2
CASP4
CASP6
CASP7
CASP9
CDC42
CDH5
COL17A1
COPS6
DES
DSC1
ENO3
EVPL
H19
IVL
JUP
KRT1
KRT5
KRT6A
MTDH
PECAM1
PKP1
PKP2
PKP3
PKP4
PRKACA
PRKCE
PTEN
RNF10
TTC3
UCHL5
USP7
VIM
WEE2-AS1
Entrez ID
3853
1832
HPRD ID
01011
00513
Ensembl ID
ENSG00000205420
ENSG00000096696
Uniprot IDs
A0A0S2Z428
P02538
A0AAQ5BH43
B4DKX6
P15924
PDB IDs
5KI0
1LM5
1LM7
3R6N
5DZZ
Enriched GO Terms of Interacting Partners
?
Intermediate Filament Organization
Intermediate Filament-based Process
Intermediate Filament Cytoskeleton Organization
Structural Constituent Of Skin Epidermis
Keratin Filament
Intermediate Filament
Structural Molecule Activity
Supramolecular Fiber Organization
Cytoskeleton Organization
Epithelial Cell Differentiation
Cytoskeleton
Organelle Organization
Tissue Morphogenesis
Morphogenesis Of An Epithelium
Structural Constituent Of Cytoskeleton
Keratinization
Extracellular Exosome
Cellular Developmental Process
Intermediate Filament Cytoskeleton
Cell Differentiation
Anatomical Structure Morphogenesis
Hair Follicle Morphogenesis
Epidermis Development
Developmental Process
Scaffold Protein Binding
Cytosol
Hair Cycle Process
Protein Binding
Adherens Junction
Cornified Envelope
Tissue Development
Epithelial Cell-cell Adhesion
Peptide Cross-linking
Positive Regulation Of ERAD Pathway
Cornified Envelope
Desmosome
Intermediate Filament Cytoskeleton Organization
Intermediate Filament-based Process
Intermediate Filament
Cysteine-type Endopeptidase Activity
Cell-cell Junction Organization
Desmosome Organization
Cell Junction Assembly
Intermediate Filament Organization
Cysteine-type Peptidase Activity
Cell-cell Junction
Anchoring Junction
Desmosome Assembly
Cell Junction Organization
Positive Regulation Of Neuron Apoptotic Process
Cell-cell Junction Assembly
Cytoplasm
Peptidase Activity
Keratinization
Alpha-catenin Binding
Adherens Junction
Intermediate Filament Cytoskeleton
Cadherin Binding
Desmosome Maintenance
Cytoskeleton Organization
Cytosol
Peptide Cross-linking
Structural Constituent Of Skin Epidermis
Supramolecular Fiber Organization
Cell-cell Adhesion
Cell Adhesion
Epidermis Development
Cellular Component Assembly
Positive Regulation Of Signal Transduction
Regulation Of Neuron Apoptotic Process
Execution Phase Of Apoptosis
Proteolysis
Cellular Response To Staurosporine
Protein Metabolic Process
Protein Processing
Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
Protein Maturation
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Cell Periphery
Response To Indole-3-methanol
Cell Junction
Structural Constituent Of Cytoskeleton
Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication
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Tagcloud (Intersection)
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