AZGP1 and ABCC1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		AZGP1	ABCC1
Description		alpha-2-glycoprotein 1, zinc-binding	ATP binding cassette subfamily C member 1 (ABCC1 blood group)
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus External Side Of Plasma Membrane Extracellular Exosome	Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Extracellular Exosome
	Molecular Function	RNA Nuclease Activity Protein Binding Protein Transmembrane Transporter Activity	Nucleotide Binding ATP Binding ABC-type Xenobiotic Transporter Activity ABC-type Vitamin B12 Transporter Activity ABC-type Glutathione S-conjugate Transporter Activity Efflux Transmembrane Transporter Activity Hydrolase Activity ATP Hydrolysis Activity Transmembrane Transporter Activity ATPase-coupled Lipid Transmembrane Transporter Activity Glutathione Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Sphingolipid Transporter Activity Carboxylic Acid Transmembrane Transporter Activity ABC-type Transporter Activity
	Biological Process	Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Immune Response Cell Adhesion Negative Regulation Of Cell Population Proliferation Protein Transmembrane Transport	Leukotriene Metabolic Process Xenobiotic Metabolic Process Lipid Transport Response To Xenobiotic Stimulus Cobalamin Transport Sphingolipid Biosynthetic Process Cellular Response To Oxidative Stress Glutathione Transmembrane Transport Heme Catabolic Process Xenobiotic Transport Phospholipid Translocation Carboxylic Acid Transport Positive Regulation Of Inflammatory Response Transmembrane Transport Cell Chemotaxis Transepithelial Transport Cyclic Nucleotide Transport Leukotriene Transport Monoatomic Anion Transmembrane Transport Sphingolipid Translocation Export Across Plasma Membrane Transport Across Blood-brain Barrier Cellular Response To Amyloid-beta Carboxylic Acid Transmembrane Transport Xenobiotic Transport Across Blood-brain Barrier
Pathways		Miscellaneous transport and binding events	Sphingolipid de novo biosynthesis Heme degradation Synthesis of Leukotrienes (LT) and Eoxins (EX) ABC-family proteins mediated transport Cytoprotection by HMOX1 Paracetamol ADME Transport of RCbl within the body NFE2L2 regulating MDR associated enzymes
Drugs		N-acetyl-alpha-neuraminic acid Copper	ATP Sulfinpyrazone Biricodar Romidepsin Leukotriene C4
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Red blood cell count ( 27863252) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31152163) Hip circumference adjusted for BMI ( 34021172) Ischemic stroke (undetermined subtype) ( 26708676) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Multiple myeloma (survival) ( 26198393) Pelvic organ prolapse (moderate/severe) ( 26545240) Psychosis proneness (perceptual aberration scale) ( 28525603) Rate of ventricular enlargement ( 31711042) Red cell distribution width ( 32888494) Response to antiepileptic mood-stabilizing treatment in bipolar disorder ( 32627186) Serum metabolite levels ( 33031748) Severe autoimmune type 2 diabetes ( 34737425) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) White blood cell count (basophil) ( 27863252)
Interacting Genes		5 interacting genes: ABCC1 ITGAV NUF2 SHBG UBQLN2	7 interacting genes: ATP5F1A AZGP1 CSNK2A1 FILNC1 NPM1 NR3C1 TRAF3
Entrez ID		563	4363
HPRD ID		01910	01153
Ensembl ID		ENSG00000160862	ENSG00000103222
Uniprot IDs		A0A140VK00 P25311	A0A7I2V2E0 P33527
PDB IDs		1T7V 1T7W 1T7X 1T7Y 1T7Z 1T80 1ZAG 3ES6 6R2U	2CBZ 4C3Z 8VT4 8VUX 8VVC
Enriched GO Terms of Interacting Partners?		Entry Into Host Cell By A Symbiont-containing Vacuole Integrin Alphav-beta3 Complex Integrin Alphav-beta5 Complex Negative Regulation Of Entry Of Bacterium Into Host Cell Integrin Alphav-beta1 Complex Integrin Alphav-beta6 Complex Opsonin Binding Integrin Alphav-beta8 Complex ABC-type Vitamin B12 Transporter Activity ATPase-coupled Lipid Transmembrane Transporter Activity Sphingolipid Transporter Activity Negative Regulation Of G Protein-coupled Receptor Internalization Apolipoprotein A-I-mediated Signaling Pathway C-X3-C Chemokine Binding Alphav-beta3 Integrin-PKCalpha Complex Negative Regulation Of Lipoprotein Metabolic Process Neuregulin Binding Alphav-beta3 Integrin-IGF-1-IGF1R Complex Alphav-beta3 Integrin-HMGB1 Complex Extracellular Matrix Protein Binding Sphingolipid Translocation Carboxylic Acid Transmembrane Transporter Activity Androgen Binding Negative Regulation Of Clathrin-dependent Endocytosis Ndc80 Complex Xenobiotic Transport Across Blood-brain Barrier Regulation Of Entry Of Bacterium Into Host Cell Transforming Growth Factor Beta Production Glutathione Transmembrane Transporter Activity Leukotriene Transport Locomotion Negative Regulation Of Low-density Lipoprotein Particle Clearance Insulin-like Growth Factor I Binding Regulation Of Lipoprotein Metabolic Process Positive Regulation Of Osteoblast Proliferation Chemotaxis Regulation Of Endocytosis Negative Regulation Of Macrophage Derived Foam Cell Differentiation Cyclic Nucleotide Transport Efflux Transmembrane Transporter Activity Porphyrin-containing Compound Catabolic Process ABC-type Xenobiotic Transporter Activity Glutathione Transport Glutathione Transmembrane Transport Cobalamin Transport ABC-type Glutathione S-conjugate Transporter Activity Heme Catabolic Process ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Meiotic Chromosome Segregation Wound Healing, Spreading Of Epidermal Cells	Core Promoter Sequence-specific DNA Binding Cellular Response To Dexamethasone Stimulus Response To Dexamethasone Hsp90 Protein Binding Macrophage Differentiation Adenyl Ribonucleotide Binding Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Tumor Necrosis Factor-mediated Signaling Pathway Nuclear Glucocorticoid Receptor Activity Regulation Of MRNA Stability Involved In Cellular Response To UV Regulation Of EIF2 Alpha Phosphorylation By DsRNA Cellular Response To Steroid Hormone Stimulus Protein Kinase Binding Regulation Of Endoribonuclease Activity Regulation Of Translational Initiation Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Signal Transduction By P53 Class Mediator
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