CP and MPO

Number of citations of the paper that reports this interaction (PubMedID 9097926)
0

Data Source:
HPRD (in vitro)

		CP	MPO
Description		ceruloplasmin	myeloperoxidase
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosomal Membrane Endoplasmic Reticulum Lumen Plasma Membrane Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Nucleus Nucleoplasm Lysosome Secretory Granule Azurophil Granule Lumen Azurophil Granule Extracellular Exosome Phagocytic Vesicle Lumen
	Molecular Function	Ferroxidase Activity Glutathione Peroxidase Activity Copper Ion Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Metal Ions Oxidoreductase Activity, Acting On Metal Ions, Oxygen As Acceptor Metal Ion Binding Phospholipid-hydroperoxide Glutathione Peroxidase Activity Protein-folding Chaperone Binding	Chromatin Binding Peroxidase Activity Protein Binding Heparin Binding Oxidoreductase Activity Heme Binding Metal Ion Binding
	Biological Process	Intracellular Copper Ion Homeostasis Intracellular Iron Ion Homeostasis Cellular Oxidant Detoxification	Response To Yeast Hypochlorous Acid Biosynthetic Process Respiratory Burst Involved In Defense Response Defense Response Response To Oxidative Stress Response To Mechanical Stimulus Removal Of Superoxide Radicals Response To Food Response To Lipopolysaccharide Low-density Lipoprotein Particle Remodeling Defense Response To Bacterium Hydrogen Peroxide Catabolic Process Negative Regulation Of Apoptotic Process Defense Response To Fungus Response To Gold Nanoparticle
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Metal ion SLC transporters Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) Defective CP causes aceruloplasminemia (ACERULOP) Post-translational protein phosphorylation Iron uptake and transport	Neutrophil degranulation Events associated with phagocytolytic activity of PMN cells
Drugs		Calcium Iron Zinc Silver Zinc acetate Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate Zinc chloride Zinc sulfate, unspecified form	Cefdinir Levocarnitine Melatonin Nomifensine
Diseases			Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Subcutaneous adipose tissue ( 22589738)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Blood protein levels in cardiovascular risk ( 28369058) Circulating myeloperoxidase levels (plasma) ( 23620142) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 27863252 32888494) Multiple sclerosis ( 31604244) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 27863252 32888494) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 27863252)
Interacting Genes		8 interacting genes: ATP7A BTRC GAST HSP90AA1 LTF MPO PLG PROC	3 interacting genes: CEBPA CP PTP4A2
Entrez ID		1356	4353
HPRD ID		00317	06102
Ensembl ID		ENSG00000047457	ENSG00000005381
Uniprot IDs		A5PL27 P00450	P05164
PDB IDs		1KCW 2J5W 4EJX 4ENZ	1CXP 1D2V 1D5L 1D7W 1DNU 1DNW 1MHL 1MYP 3F9P 3ZS0 3ZS1 4C1M 4DL1 4EJX 5FIW 5MFA 5UZU 6AZP 6BMT 7OIH
Enriched GO Terms of Interacting Partners?		Phagocytic Vesicle Lumen Removal Of Superoxide Radicals Serine-type Peptidase Activity Immune System Process Serine-type Endopeptidase Activity Extracellular Region Response To Food Biological Process Involved In Interaction With Symbiont Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Superoxide Metabolic Process Extracellular Space Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Defense Response To Fungus Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Protein Metabolic Process CTP Binding DATP Binding Response To Fungus Negative Regulation Of Tumor Necrosis Factor (ligand) Superfamily Member 11 Production Hypochlorous Acid Biosynthetic Process Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Tissue Remodeling P-type Divalent Copper Transporter Activity P-type Monovalent Copper Transporter Activity Cellular Oxidant Detoxification Reactive Oxygen Species Metabolic Process Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism Peptidase Activity Response To Gold Nanoparticle Endopeptidase Activity Protein Phosphorylated Amino Acid Binding Secretory Granule Blood Coagulation Coagulation Cellular Detoxification Hemostasis Response To Nutrient Levels Superoxide Dismutase Copper Chaperone Activity Copper-dependent Protein Binding Copper Ion Export Rho GDP-dissociation Inhibitor Binding	Carbohydrate Homeostasis CHOP-C/EBP Complex Glucose Homeostasis Lipid Homeostasis RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Chemical Homeostasis Response To Vitamin B2 White Fat Cell Proliferation C/EBP Complex Oxidoreductase Activity, Acting On Metal Ions, Oxygen As Acceptor Phospholipid-hydroperoxide Glutathione Peroxidase Activity Ferroxidase Activity Oxidoreductase Activity, Acting On Metal Ions Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Positive Regulation Of Type B Pancreatic Cell Proliferation Protein Domain Specific Binding Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Response To Phenylpropanoid Gland Development Homeostatic Process Phosphatidylinositol 3-kinase Activator Activity Fat Cell Proliferation Negative Regulation Of Fatty Acid Transport Regulation Of Long-chain Fatty Acid Import Into Cell Positive Regulation Of Fatty Acid Beta-oxidation Response To Lithium Ion Transcription By RNA Polymerase I Urea Metabolic Process Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion HMG Box Domain Binding Nitrogen Cycle Metabolic Process White Fat Cell Differentiation Urea Cycle Interleukin-6-mediated Signaling Pathway Positive Regulation Of Cell Activation STAT Family Protein Binding Osteoblast Development Intracellular Copper Ion Homeostasis Regulation Of Fatty Acid Beta-oxidation Phosphatidylinositol 3-kinase Binding Negative Regulation Of B Cell Apoptotic Process Positive Regulation Of Glycogen Biosynthetic Process Regulation Of Type B Pancreatic Cell Proliferation Positive Regulation Of Fatty Acid Oxidation Response To Endothelin Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Cellular Response To Endothelin Type B Pancreatic Cell Proliferation
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