PRM1 and LBR

Number of citations: 0 (PubMedID 14701833)
Data Source: HPRD (in vitro)

		PRM1	LBR
Name		protamine 1	lamin B receptor
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleosome Nucleus Nucleoplasm Chromosome Cytosol	Fibrillar Center Nucleus Nuclear Envelope Nuclear Inner Membrane Nuclear Lamina Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Nuclear Membrane
	Molecular Function	DNA Binding Protein Binding	DNA Binding RNA Binding Protein Binding Lamin Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors, NAD Or NADP As Acceptor Delta14-sterol Reductase Activity Chromo Shadow Domain Binding NADPH Binding Chromatin-protein Adaptor Activity
	Biological Process	Spermatogenesis Cell Differentiation Chromosome Condensation Sperm DNA Condensation Chromosome Organization	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Sterol Biosynthetic Process Neutrophil Differentiation Random Inactivation Of X Chromosome
Pathways		Replacement of protamines by nucleosomes in the male pronucleus	Cholesterol biosynthesis Initiation of Nuclear Envelope (NE) Reformation RHOA GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Regulation of MECP2 expression and activity
Diseases		None	HEM skeletal dysplasia; Greenberg dysplasia Pelger-Huet anomaly
GWAS		Asthma ( 31959851 ) Bulimia nervosa ( 23568457 ) Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 28067908 ) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761 ) Multiple sclerosis ( 22190364 31604244 ) Multiple sclerosis and type 2 diabetes (pleiotropy) ( 26920376 ) Obesity-related traits ( 23251661 ) Primary biliary cirrhosis ( 22961000 )	Delirium ( 29631748 ) LDL cholesterol levels in HIV infection ( 33109212 ) Mean corpuscular volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 )
Novel Interactors		1 novel interactors: GRIN2A	1 novel interactors: SFTPD
Interacting Genes		3 interacting genes: CLK2 LBR SRPK1	13 interacting genes: AKAP8L CALD1 CBX3 CBX5 CD81 FNBP4 H4C14 KPNB1 LMNB1 PRM1 SRPK1 SRPK2 YWHAG
Entrez ID		5619	3930
HPRD ID		01688	02488
Ensembl ID		ENSG00000175646	ENSG00000143815
Uniprot IDs		P04553 Q3MN80	Q14739
PDB IDs		Not available	2DIG
GO Terms Enriched among Interactors		None	Chromatin Organization Nuclear Envelope Protein Localization To Organelle Nucleoplasm Chromatin Remodeling Heterochromatin Formation Nuclear Matrix Chromosome Sperm DNA Condensation Positive Regulation Of Viral Genome Replication Pericentric Heterochromatin Negative Regulation Of Gene Expression, Epigenetic Chromosome, Telomeric Region Chromosome Condensation Macrophage Fusion Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Regulation Of Gene Expression Protein Domain Specific Binding RNA Binding Nuclear Inner Membrane Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Site Of DNA Damage Heterochromatin Regulation Of Macromolecule Biosynthetic Process Protein Localization To Lysosome Positive Regulation Of Viral Process Epigenetic Regulation Of Gene Expression Positive Regulation Of T Cell Mediated Immunity Negative Regulation Of Gene Expression Structural Constituent Of Nuclear Lamina Negative Regulation Of Viral Process Regulation Of Viral Genome Replication Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Protein Localization To Vacuole Myoblast Fusion Involved In Skeletal Muscle Regeneration Nucleus Organization Chromosome Organization Protein Kinase C Inhibitor Activity Chromatin Lock Complex Regulation Of Macromolecule Metabolic Process Actin Cap Regulation Of T Cell Mediated Immunity Mitotic Chromosome Movement Towards Spindle Pole Ribosomal Protein Import Into Nucleus RNA Import Into Nucleus RNA Splicing Nuclear Speck Organization Senescence-associated Heterochromatin Focus