GADD45B and PPARD

Number of citations of the paper that reports this interaction (PMID 10872826)
14

Data Source:
HPRD (in vitro)

		GADD45B	PPARD
Gene Name		growth arrest and DNA-damage-inducible, beta	peroxisome proliferator-activated receptor delta
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleoplasm
	Molecular Function	Protein Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Coactivator Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Drug Binding Zinc Ion Binding Lipid Binding Sequence-specific DNA Binding NF-kappaB Binding Linoleic Acid Binding
	Biological Process	Activation Of MAPKKK Activity Activation Of MAPKK Activity Negative Regulation Of Protein Kinase Activity Apoptotic Process Response To Stress Multicellular Organismal Development Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of JNK Cascade Regulation Of Cell Cycle Positive Regulation Of P38MAPK Cascade	Negative Regulation Of Transcription From RNA Polymerase II Promoter Glucose Metabolic Process Proteoglycan Metabolic Process Generation Of Precursor Metabolites And Energy Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Lipid Metabolic Process Fatty Acid Beta-oxidation Vitamin A Metabolic Process Heart Development Embryo Implantation Cholesterol Metabolic Process Cell Proliferation Positive Regulation Of Cell Proliferation Axon Ensheathment Phospholipid Biosynthetic Process Fatty Acid Catabolic Process MRNA Transcription Response To Glucose Gene Expression Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Response To Activity Negative Regulation Of Smooth Muscle Cell Migration Glucose Transport Fatty Acid Transport Cell Differentiation Negative Regulation Of Cell Growth Intracellular Receptor Signaling Pathway Cell-substrate Adhesion Positive Regulation Of Insulin Secretion Negative Regulation Of Collagen Biosynthetic Process Response To Vitamin A Wound Healing Negative Regulation Of Apoptotic Process Steroid Hormone Mediated Signaling Pathway Keratinocyte Proliferation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Epidermis Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Vasodilation Decidualization Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Inflammatory Response Keratinocyte Migration Adipose Tissue Development Cellular Response To Hypoxia Apoptotic Signaling Pathway
Pathways			Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Signaling by Retinoic Acid Import of palmitoyl-CoA into the mitochondrial matrix Pyruvate metabolism and Citric Acid (TCA) cycle Nuclear Receptor transcription pathway The citric acid (TCA) cycle and respiratory electron transport
Drugs			Icosapent Treprostinil Sulindac Bezafibrate Heptyl-Beta-D-Glucopyranoside (11E)-OCTADEC-11-ENOIC ACID (2S)-2-{3-[({[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}amino)methyl]-4-methoxybenzyl}butanoic acid 2-({[3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)phenyl]carbonyl}amino)benzoic acid 3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid {4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy}acetic acid
Diseases
GWAS			Cataracts in type 2 diabetes ( 23137000) Height ( 21998595) Pulmonary function (interaction) ( 23284291) Response to antipsychotic treatment ( 20195266)
Protein-Protein Interactions		13 interactors: CCNB1 CDK1 CDKN1A ESR1 GADD45G GADD45GIP1 MAP2K7 MAP3K4 MAP3K5 PCNA PPARA PPARD PPARG	39 interactors: BCL6 CEP350 DUT EIF3I EP300 GADD45B GADD45G GLUL HDAC1 HDAC2 HDAC3 HDAC4 HDAC7 HSP90AA1 ITGB5 KDM1A KRTAP10-3 KRTAP10-7 NCOA1 NCOA2 NCOA3 NCOR1 NCOR2 NR0B2 NRIP1 PEBP1 PPARGC1A PRDX6 PRMT3 PROX1 RANBP9 RXRA RXRB RXRG SHMT2 SMAD9 SPEN SRC TNP1
Entrez ID		4616	5467
HPRD ID		05382	02679
Ensembl ID		ENSG00000099860	ENSG00000112033
Uniprot IDs		O75293	F1D8S7 Q03181
PDB IDs			1GWX 1Y0S 2AWH 2B50 2BAW 2ENV 2GWX 2J14 2Q5G 2XYJ 2XYW 2XYX 2ZNP 2ZNQ 3D5F 3DY6 3ET2 3GWX 3GZ9 3OZ0 3PEQ 3SP9 3TKM
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Cell Death Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Activation Of MAPKK Activity Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity Response To Lipid Positive Regulation Of Kinase Activity Positive Regulation Of Phosphorylation Response To Organic Cyclic Compound Heart Development Positive Regulation Of Protein Modification Process Regulation Of Fibroblast Proliferation Regulation Of Apoptotic Process Steroid Hormone Mediated Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Apoptotic Process Cellular Response To Stress Programmed Cell Death Cell Death Death Positive Regulation Of JNK Cascade Regulation Of Protein Phosphorylation Response To Abiotic Stimulus Hormone-mediated Signaling Pathway Tissue Development Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Response To Stress Response To Organic Substance Activation Of MAPK Activity Cellular Response To Organic Substance G1/S Transition Of Mitotic Cell Cycle Cellular Response To Organic Cyclic Compound Positive Regulation Of Signal Transduction Regulation Of JNK Cascade Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Lipid Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Intracellular Signal Transduction	Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Transcription, DNA-templated Negative Regulation Of Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Rhythmic Process Chromatin Organization Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Modification Positive Regulation Of Metabolic Process Circadian Rhythm Response To Organic Substance Histone Modification Cellular Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Circadian Regulation Of Gene Expression Gene Expression Regulation Of Transcription, DNA-templated Histone H4 Deacetylation Multicellular Organismal Development Cellular Response To Organic Substance Organelle Organization Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Biosynthetic Process RNA Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Chromosome Organization Developmental Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Histone H3 Deacetylation
Tagcloud ?		abrogated abundance antiapoptotic barely bbc3 bovine cessation coculture collectively cyp19a1 detectable encoding estradiol faslg favored fgf fgf10 fgf18 fgf2 fibroblast follicle follicles gonadotropic granulosa mdm2 mitotic proapoptotic reversed withdrawing	almendro birc5 casein catenin cd44 deregulate distinguished dvl1 ffpe fzd7 gonen ly294002 martins mimicking mmp7 modulators notch1 pam50 park pten readout subpopulation sulfide sulindac tnbc wp xav939 zymograph
Tagcloud (Difference) ?		abrogated abundance antiapoptotic barely bbc3 bovine cessation coculture collectively cyp19a1 detectable encoding estradiol faslg favored fgf fgf10 fgf18 fgf2 fibroblast follicle follicles gonadotropic granulosa mdm2 mitotic proapoptotic reversed withdrawing	almendro birc5 casein catenin cd44 deregulate distinguished dvl1 ffpe fzd7 gonen ly294002 martins mimicking mmp7 modulators notch1 pam50 park pten readout subpopulation sulfide sulindac tnbc wp xav939 zymograph
Tagcloud (Intersection) ?