BIN3 and GINS4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BIN3	GINS4
Description		bridging integrator 3	GINS complex subunit 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Actin Cytoskeleton	GINS Complex Nucleus Nucleoplasm Chromosome Cytoplasm CMG Complex
	Molecular Function	Protein Binding Cytoskeletal Anchor Activity Lipid Binding	Protein Binding
	Biological Process	Endocytosis Actin Filament Organization Intracellular Protein Localization Unidimensional Cell Growth Regulation Of Lamellipodium Assembly Myoblast Migration Involved In Skeletal Muscle Regeneration Skeletal Muscle Tissue Regeneration Developmental Growth Skeletal Muscle Fiber Development Cell Division Actin Cortical Patch Localization Cytoskeleton-dependent Cytokinesis Plasma Membrane Tubulation	Double-strand Break Repair Via Break-induced Replication Inner Cell Mass Cell Proliferation DNA Replication DNA-templated DNA Replication
Pathways			Unwinding of DNA Unwinding of DNA
Drugs
Diseases
GWAS		Cataracts ( 34127677) Estimated glomerular filtration rate ( 31152163) Exploratory eye movement dysfunction in schizophrenia (cognitive search score) ( 26242244) Heel bone mineral density ( 30598549) Parkinson's disease ( 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		9 interacting genes: ABI2 C14orf119 GINS4 NXF1 POLR1C RPRD1B TRIM69 TXLNA UBL5	12 interacting genes: - BIN3 CTNNBIP1 DMAP1 GINS2 KIF16B LHX8 PBX4 POLA1 POLD1 POLE PPP1R13B
Entrez ID		55909	84296
HPRD ID		05904	11583
Ensembl ID		ENSG00000147439	ENSG00000147536
Uniprot IDs		E5RHU4 H7BYV6 Q9NQY0	Q9BRT9
PDB IDs			2E9X 2EHO 2Q9Q 6XTX 6XTY 7PFO 7PLO 8B9D 8OK2
Enriched GO Terms of Interacting Partners?			DNA Polymerase Activity DNA-directed DNA Polymerase Activity DNA Replication Proofreading DNA Synthesis Involved In DNA Repair Leading Strand Elongation DNA Replication DNA-templated DNA Replication Nucleotide-excision Repair, DNA Gap Filling DNA Repair DNA Strand Elongation Involved In DNA Replication Nucleotidyltransferase Activity DNA Biosynthetic Process Base-excision Repair, Gap-filling DNA Strand Elongation DNA Metabolic Process DNA Damage Response 4 Iron, 4 Sulfur Cluster Binding Actin Cortical Patch Localization Regulation Of Vascular Permeability Involved In Acute Inflammatory Response Iron-sulfur Cluster Binding Beta-catenin-ICAT Complex Indoleamine 2,3-dioxygenase Activity Lagging Strand Elongation DNA Synthesis Involved In UV-damage Excision Repair Unidimensional Cell Growth Tryptophan 2,3-dioxygenase Activity Mitotic DNA Replication Initiation Nucleobase-containing Compound Biosynthetic Process Alpha DNA Polymerase:primase Complex Error-free Translesion Synthesis Delta DNA Polymerase Complex Epsilon DNA Polymerase Complex Single-stranded DNA 3'-5' DNA Exonuclease Activity GINS Complex Myoblast Migration Involved In Skeletal Muscle Regeneration Response To Ethanol L-tryptophan Catabolic Process To Kynurenine Cellular Response To Stress DNA Replication, Synthesis Of Primer Nucleotide-excision Repair Complex Negative Regulation Of DNA-templated Transcription Initiation Negative Regulation Of Transcription Initiation By RNA Polymerase II
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