UNC45A and CRTC3

Data Source: HiPPIP (Novel)

		UNC45A	CRTC3
Name		unc-45 myosin chaperone A	CREB regulated transcription coactivator 3
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Cytosol Nuclear Speck Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Cadherin Binding Hsp90 Protein Binding	Transcription Coactivator Activity Protein Binding CAMP Response Element Binding Protein Binding
	Biological Process	Protein Folding Muscle Organ Development Cell Differentiation	Lipid Catabolic Process Macrophage Activation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Lipid Catabolic Process Protein Homotetramerization Cellular Response To CAMP Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Energy Homeostasis
Pathways		None	Transcriptional activation of mitochondrial biogenesis Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2
GWAS		No GWAS studies recorded	Apolipoprotein B levels ( 32203549 ) Chromium levels ( 26025379 ) Chronic postoperative pain ( 31903573 ) Colorectal cancer ( 29228715 ) Daytime sleep phenotypes ( 27126917 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Gastroesophageal reflux disease ( 27485664 ) Heel bone mineral density ( 28869591 ) Inflammatory bowel disease ( 23128233 28067908 ) Information processing speed ( 21130836 ) Male-pattern baldness ( 28196072 ) Offspring birth weight ( 31043758 ) Response to exercise (triglyceride level interaction) ( 26491034 ) Ulcerative colitis ( 28067908 )
Novel Interactors		1 novel interactors: CRTC3	8 novel interactors: AEN C15orf32 HAPLN3 RCCD1 RGMA TICRR UNC45A WDR93
Interacting Genes		13 interacting genes: DIRAS2 HSP90AA1 HSP90AB1 KRTAP10-3 LMNA MARCHF10 MAX MEOX1 MEOX2 MID2 PIBF1 SMAD9 TEKT1	5 interacting genes: CA13 KLHL12 SIK2 YAP1 YWHAG
Entrez ID		55898	64784
HPRD ID		18070	13384
Ensembl ID		ENSG00000140553	ENSG00000140577
Uniprot IDs		Q9H3U1	Q6UUV7
PDB IDs		2DBA	Not available
GO Terms Enriched among Interactors		Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Somite Specification Telomerase Holoenzyme Complex Assembly Positive Regulation Of Macromolecule Metabolic Process Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone TPR Domain Binding Positive Regulation Of Macromolecule Biosynthetic Process Segment Specification Somite Development Chaperone-mediated Protein Complex Assembly Regulation Of Primary Metabolic Process Telomere Maintenance Via Telomerase DNA Polymerase Binding Axonal Growth Cone RNA-templated DNA Biosynthetic Process MHC Class II Protein Complex Binding Disordered Domain Specific Binding Telomere Maintenance Via Telomere Lengthening Protein Folding Chaperone Complex ATP-dependent Protein Folding Chaperone Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nitric Oxide Metabolic Process Tau Protein Binding Protein Localization To Cytoskeleton CTP Binding DATP Binding Cellular Response To Heat Protein Folding Chaperone Regulation Of Metabolic Process Embryonic Pattern Specification Regulation Of Nitric Oxide Biosynthetic Process Protein Localization To Organelle Regulation Of Protein Modification Process Regulation Of Nitric Oxide Metabolic Process Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding HSP90-CDC37 Chaperone Complex DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Myc-Max Complex Mad-Max Complex Negative Regulation Of Prostaglandin Biosynthetic Process DNA-binding Transcription Factor Activity	None