CRTC3 and RGMA

Data Source: HiPPIP (Novel)

		CRTC3	RGMA
Name		CREB regulated transcription coactivator 3	repulsive guidance molecule BMP co-receptor a
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Endoplasmic Reticulum Plasma Membrane Cell Surface Membrane Side Of Membrane
	Molecular Function	Transcription Coactivator Activity Protein Binding CAMP Response Element Binding Protein Binding	Signaling Receptor Binding Protein Binding Coreceptor Activity Transferrin Receptor Binding
	Biological Process	Lipid Catabolic Process Macrophage Activation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Lipid Catabolic Process Protein Homotetramerization Cellular Response To CAMP Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Energy Homeostasis	Neural Tube Closure Membrane Protein Ectodomain Proteolysis Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development BMP Signaling Pathway Regulation Of BMP Signaling Pathway Neuron Projection Development Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Primary Metabolic Process
Pathways		Transcriptional activation of mitochondrial biogenesis Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2	Netrin-1 signaling
GWAS		Apolipoprotein B levels ( 32203549 ) Chromium levels ( 26025379 ) Chronic postoperative pain ( 31903573 ) Colorectal cancer ( 29228715 ) Daytime sleep phenotypes ( 27126917 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Gastroesophageal reflux disease ( 27485664 ) Heel bone mineral density ( 28869591 ) Inflammatory bowel disease ( 23128233 28067908 ) Information processing speed ( 21130836 ) Male-pattern baldness ( 28196072 ) Offspring birth weight ( 31043758 ) Response to exercise (triglyceride level interaction) ( 26491034 ) Ulcerative colitis ( 28067908 )	Blood protein levels ( 30072576 ) Copper levels ( 26025379 ) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535 ) Heel bone mineral density ( 30598549 ) Metabolite levels ( 23823483 ) Opioid dependence ( 29478698 ) Overweight status ( 25133637 ) Periodontitis (CDC/AAP) ( 24024966 ) Refractive error ( 32231278 ) Response to angiotensin II receptor blocker therapy (opposite direction w/ diuretic therapy) ( 22566498 ) Type 1 diabetes nephropathy ( 23028342 ) Type 2 diabetes ( 32499647 )
Novel Interactors		8 novel interactors: AEN C15orf32 HAPLN3 RCCD1 RGMA TICRR UNC45A WDR93	1 novel interactors: CRTC3
Interacting Genes		5 interacting genes: CA13 KLHL12 SIK2 YAP1 YWHAG	4 interacting genes: PPP1R16A SGSM2 TERF2IP TP53BP2
Entrez ID		64784	56963
HPRD ID		13384	09560
Ensembl ID		ENSG00000140577	ENSG00000182175
Uniprot IDs		Q6UUV7	A0A0A0MTQ4 Q96B86
PDB IDs		Not available	4UHY 6Z3G