UNC45A and DIRAS2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		UNC45A	DIRAS2
Description		unc-45 myosin chaperone A	DIRAS family GTPase 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Cytosol Nuclear Speck Perinuclear Region Of Cytoplasm	Plasma Membrane Membrane
	Molecular Function	Protein Binding Cadherin Binding Hsp90 Protein Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding
	Biological Process	Protein Folding Muscle Organ Development Cell Differentiation	Signal Transduction Positive Regulation Of MAP Kinase Activity
Pathways
Drugs
Diseases
GWAS			Cognitive test performance ( 17903297) Logical memory (immediate recall) in Alzheimer's disease dementia ( 29274321) Multiple sclerosis ( 31604244) Protein quantitative trait loci ( 18464913)
Interacting Genes		13 interacting genes: DIRAS2 HSP90AA1 HSP90AB1 KRTAP10-3 LMNA MARCHF10 MAX MEOX1 MEOX2 MID2 PIBF1 SMAD9 TEKT1	2 interacting genes: RIPPLY1 UNC45A
Entrez ID		55898	54769
HPRD ID		18070	09711
Ensembl ID		ENSG00000140553	ENSG00000165023
Uniprot IDs		Q9H3U1	Q96HU8
PDB IDs		2DBA	2ERX 6NAZ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Somite Specification Telomerase Holoenzyme Complex Assembly Positive Regulation Of Macromolecule Metabolic Process Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone TPR Domain Binding Positive Regulation Of Macromolecule Biosynthetic Process Segment Specification Somite Development Chaperone-mediated Protein Complex Assembly Regulation Of Primary Metabolic Process Telomere Maintenance Via Telomerase DNA Polymerase Binding Axonal Growth Cone RNA-templated DNA Biosynthetic Process MHC Class II Protein Complex Binding Disordered Domain Specific Binding Telomere Maintenance Via Telomere Lengthening Protein Folding Chaperone Complex ATP-dependent Protein Folding Chaperone Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nitric Oxide Metabolic Process Tau Protein Binding Protein Localization To Cytoskeleton CTP Binding DATP Binding Cellular Response To Heat Protein Folding Chaperone Regulation Of Metabolic Process Embryonic Pattern Specification Regulation Of Nitric Oxide Biosynthetic Process Protein Localization To Organelle Regulation Of Protein Modification Process Regulation Of Nitric Oxide Metabolic Process Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding HSP90-CDC37 Chaperone Complex DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Myc-Max Complex Mad-Max Complex Negative Regulation Of Prostaglandin Biosynthetic Process DNA-binding Transcription Factor Activity	Somite Rostral/caudal Axis Specification Somite Specification Segment Specification Hsp90 Protein Binding Anterior/posterior Axis Specification Embryonic Axis Specification
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