ZNF395 and WASL

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ZNF395	WASL
Gene Name		zinc finger protein 395	Wiskott-Aldrich syndrome-like
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Cytosol Plasma Membrane Actin Cytoskeleton Cytoplasmic Membrane-bounded Vesicle Lamellipodium Actin Cap Endocytic Vesicle Membrane Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding DNA Binding Metal Ion Binding	Actin Binding Small GTPase Regulator Activity Protein Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Complex Assembly Membrane Budding Movement Of Cell Or Subcellular Component Mitotic Nuclear Division Axon Guidance Actin Polymerization Or Depolymerization Response To Bacterium Vesicle Organization Vesicle Transport Along Actin Filament Regulation Of Protein Localization Cellular Protein Complex Localization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Small Molecule Metabolic Process Innate Immune Response Nitric Oxide Metabolic Process Ephrin Receptor Signaling Pathway Regulation Of Nitric-oxide Synthase Activity Cell Division Positive Regulation Of Filopodium Assembly Spindle Localization Negative Regulation Of Membrane Tubulation Positive Regulation Of Clathrin-mediated Endocytosis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways			Axon guidance DCC mediated attractive signaling EPHB-mediated forward signaling Metabolism of nitric oxide NOSTRIN mediated eNOS trafficking EPH-Ephrin signaling Nephrin interactions eNOS activation and regulation Netrin-1 signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS			Platelet counts ( 22139419)
Protein-Protein Interactions		2 interactors: SAP30 WASL	47 interactors: ABL1 ACTG1 ACTR2 ACTR3 APBB1 APP ARPC3 BAIAP2 CDC42 CTTN DNMBP EVL FCHSD2 FNBP1 FNBP1L GRB2 HP HSP90AA1 HSP90AB1 IPO5 ITSN1 ITSN2 LCK NCK1 NCK2 NCKIPSD PACSIN1 PACSIN2 PACSIN3 PFN1 PRPF40A PSTPIP1 PTK6 RHOJ RHOQ RNF8 RPL7AP66 SDCBP SH3GL3 SNX9 SRC TRIP10 VASP VIPR1 WIPF1 WIPF2 ZNF395
Entrez ID		55893	8976
HPRD ID		11711	05448
Ensembl ID		ENSG00000186918	ENSG00000106299
Uniprot IDs		Q7L9C8 Q9H8N7	O00401
PDB IDs			2FF3 2LNH 2VCP
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Membrane Tubulation Vesicle Transport Along Actin Filament Positive Regulation Of Clathrin-mediated Endocytosis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Actin Nucleation Regulation Of Clathrin-mediated Endocytosis Cellular Protein Complex Localization Protein Complex Localization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Actin Nucleation Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Positive Regulation Of Filopodium Assembly Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Nitric-oxide Synthase Activity Regulation Of Filopodium Assembly Spindle Localization Skeletal Muscle Cell Differentiation Actin Filament-based Movement	Endocytosis Vesicle-mediated Transport Actin Filament-based Process Actin Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Cytoskeleton Organization Cell Projection Morphogenesis Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Part Morphogenesis Neuron Projection Morphogenesis Axon Guidance Fc Receptor Signaling Pathway Axonogenesis Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Morphogenesis Positive Regulation Of Cellular Component Biogenesis Axon Development Neuron Projection Development Cell Morphogenesis Involved In Neuron Differentiation Cell Projection Organization Phagocytosis Immune Response-regulating Signaling Pathway Neuron Development Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Differentiation Chemotaxis Locomotion Actin Filament Organization Innate Immune Response Neuron Differentiation Organelle Organization Positive Regulation Of Protein Complex Assembly Regulation Of Cellular Component Organization Positive Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response Positive Regulation Of Actin Filament Polymerization Generation Of Neurons Positive Regulation Of Protein Polymerization Positive Regulation Of Immune System Process Regulation Of Protein Complex Assembly Neurogenesis Regulation Of Actin Cytoskeleton Organization Immune System Process Anatomical Structure Morphogenesis Transport Defense Response Regulation Of Immune Response
Tagcloud ?		computational conducting defining deregulated destabilization destabilizes destabilizing displaying elements govern governed huntington integrating isogenic metastatic modulators overrepresented represses searches srse srses tarbp2 tbses termed transcriptionally transcripts unbiased uncovered unexplored	148a biomarker biopsies cg consensus consequences downregulated dysregulated ectopic emsa hypermethylation integrin methylated micrornas mir mirna mirnas nasopharyngeal np npc oncogenes pivotal rock1 stimulatory supporting suppressing unmethylated usf1 vav2
Tagcloud (Difference) ?		computational conducting defining deregulated destabilization destabilizes destabilizing displaying elements govern governed huntington integrating isogenic metastatic modulators overrepresented represses searches srse srses tarbp2 tbses termed transcriptionally transcripts unbiased uncovered unexplored	148a biomarker biopsies cg consensus consequences downregulated dysregulated ectopic emsa hypermethylation integrin methylated micrornas mir mirna mirnas nasopharyngeal np npc oncogenes pivotal rock1 stimulatory supporting suppressing unmethylated usf1 vav2
Tagcloud (Intersection) ?