PPP2R2D and PTTG1

Number of citations: 59 (PubMedID 16705156)
Data Source: BioGRID (enzymatic study)

		PPP2R2D	PTTG1
Name		protein phosphatase 2 regulatory subunit Bdelta	PTTG1 regulator of sister chromatid separation, securin
Structure		No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Cytoplasm Cytosol	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Protein Phosphatase Regulator Activity Enzyme-substrate Adaptor Activity	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding SH3 Domain Binding Molecular Function Activator Activity
	Biological Process	Mitotic Cell Cycle Exit From Mitosis Cell Division Regulation Of Chromosome Segregation	DNA Repair DNA Damage Response Chromosome Segregation Spermatogenesis Homologous Chromosome Segregation Chromosome Organization Cell Division
Pathways		MASTL Facilitates Mitotic Progression	APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids
GWAS		Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals ( 22959728 ) Chronotype ( 30696823 ) Household income (MTAG) ( 31844048 ) Intelligence (MTAG) ( 29326435 ) Metabolite levels ( 23823483 ) Rosacea symptom severity ( 29771307 ) Systolic blood pressure ( 30224653 30578418 )	Dermatomyositis or juvenile dermatomyositis ( 26362759 ) Insulin-related traits ( 22791750 ) Sjögren's syndrome ( 24097067 ) Systemic lupus erythematosus ( 19838195 21408207 28714469 ) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031 )
Novel Interactors		None recorded	1 novel interactors: VRK2
Interacting Genes		4 interacting genes: DAPK1 PTTG1 SUPT5H UBC	29 interacting genes: ANAPC1 ANAPC11 ANAPC2 ANAPC4 AURKA CAMK2A CDC20 CDC27 CDC34 CDH1 CDK1 CFTR CRK CUL1 DNAJA1 FZR1 KEAP1 PLCG2 PPP2R2D PPP2R5A PRKN PTTG1IP RPS10 TP53 UBE2N UBE4A UBR5 XRCC6 ZFAND5
Entrez ID		55844	9232
HPRD ID		15172	04998
Ensembl ID		ENSG00000175470	ENSG00000164611
Uniprot IDs		Q66LE6 Q6IN90	O95997 Q6IAL9
PDB IDs		Not available	7NJ0 7NJ1
GO Terms Enriched among Interactors		DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Positive Regulation Of Autophagy DSIF Complex Regulation Of NMDA Receptor Activity Homologous Chromosome Segregation	Proteasomal Protein Catabolic Process Protein Polyubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Anaphase-promoting Complex Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Anaphase-promoting Complex-dependent Catabolic Process Protein Catabolic Process Mitotic Cell Cycle Phase Transition Proteolysis Involved In Protein Catabolic Process Cell Cycle Phase Transition Protein Ubiquitination Protein Branched Polyubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process Regulation Of Meiotic Cell Cycle Macromolecule Catabolic Process Regulation Of Chromosome Segregation Proteolysis Metaphase/anaphase Transition Of Cell Cycle Regulation Of Sister Chromatid Segregation Regulation Of Reproductive Process Regulation Of Cell Cycle Process Catabolic Process Cell Division Cytosol Regulation Of Chromosome Organization Regulation Of Mitotic Cell Cycle Protein Metabolic Process Cytoplasm Ubiquitin Protein Ligase Binding Regulation Of Cell Cycle Response To Oxidative Stress Metaphase/anaphase Transition Of Mitotic Cell Cycle Ubiquitin-protein Transferase Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Organelle Organization Protein-containing Complex Ubiquitin-protein Transferase Activator Activity Regulation Of Cell Cycle Phase Transition Regulation Of Protein Ubiquitination Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Proteasomal Protein Catabolic Process Nucleus Cullin-RING Ubiquitin Ligase Complex