VPS53

Description		VPS53 subunit of GARP complex
Image		No pdb structure
GO Annotations	Cellular Component	GARP Complex Endosome Golgi Apparatus Cytosol Endosome Membrane Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm Recycling Endosome EARP Complex
	Molecular Function	Protein Binding
	Biological Process	Protein Targeting To Lysosome Lysosomal Transport Protein Transport Vesicle-mediated Transport Cytosolic Transport Endocytic Recycling Retrograde Transport, Endosome To Golgi Vesicle-mediated Cholesterol Transport
Pathways		Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Decline in glucose metabolism in posterior cingulate cortex ( 29130521) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) joint destruction in rheumatoid arthritis (rapid vs slow) ( 33585033) Prostate cancer ( 23535732) Triglyceride levels ( 32203549) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500)
Interacting Genes		2 interacting genes: EXOC2 VPS52
Entrez ID		55275
HPRD ID		07720
Ensembl ID		ENSG00000141252
Uniprot IDs		B3KS06 Q5VIR6
PDB IDs
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport To The Plasma Membrane Post-Golgi Vesicle-mediated Transport Embryonic Ectodermal Digestive Tract Development Golgi Vesicle Transport GARP Complex EARP Complex Ectodermal Cell Differentiation Localization Within Membrane Vesicle-mediated Cholesterol Transport Regulation Of Entry Of Bacterium Into Host Cell Vesicle Tethering Involved In Exocytosis Exocyst Golgi To Vacuole Transport Embryonic Digestive Tract Development Intracellular Cholesterol Transport Intracellular Sterol Transport Intracellular Lipid Transport Vesicle-mediated Transport Protein Transport Flemming Body Vesicle Docking Involved In Exocytosis Vesicle Tethering Membrane Fission Establishment Of Protein Localization Syntaxin Binding Cellular Localization Digestive Tract Development Cholesterol Transport Mitotic Cytokinesis Vesicle Docking Golgi To Plasma Membrane Transport Endocytic Recycling Sterol Transport Organelle Localization By Membrane Tethering Intracellular Protein Localization Cytoskeleton-dependent Cytokinesis Membrane Docking Retrograde Transport, Endosome To Golgi Trans-Golgi Network Membrane Lysosomal Transport Cytosolic Transport Recycling Endosome Organic Hydroxy Compound Transport Embryonic Organ Development Vacuolar Transport Protein Targeting Exocytosis Tube Development Postsynapse Presynapse
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