NGLY1 and SH3BP1

		NGLY1	SH3BP1
Description		N-glycanase 1	SH3 domain binding protein 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Exocyst Phagocytic Cup Nucleus Cytoplasm Cytosol Plasma Membrane Adherens Junction Bicellular Tight Junction Lamellipodium Cell Leading Edge Cell Projection Anchoring Junction
	Molecular Function	Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity Protein Binding Hydrolase Activity Metal Ion Binding	GTPase Activator Activity Protein Binding SH3 Domain Binding Semaphorin Receptor Binding
	Biological Process	Protein Folding Glycoprotein Catabolic Process Positive Regulation Of BMP Signaling Pathway	Phagocytosis Phagocytosis, Engulfment Actin Filament Organization Signal Transduction Cell Migration Regulation Of Actin Filament Depolymerization Regulation Of Actin Cytoskeleton Organization Cell Junction Assembly Regulation Of Rac Protein Signal Transduction Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of GTPase Activity Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Semaphorin-plexin Signaling Pathway Ruffle Assembly
Pathways		N-glycan trimming in the ER and Calnexin/Calreticulin cycle	RAC1 GTPase cycle
Drugs
Diseases
GWAS
Interacting Genes		19 interacting genes: APP BICRAL FAF1 GUCD1 NPAS2 NSFL1C PAX5 PAX6 RAD23A RAD23B SRPK2 TCF12 TRAFD1 TRIM54 UBC UBQLN1 UBXN2B VCP VMAC	14 interacting genes: ABI2 ABI3 ABL1 CCDC146 CRK FGA HCK POT1 RAC1 RHOA SRC SYNJ1 TERF1 TRIP10
Entrez ID		55768	23616
HPRD ID		10118	10227
Ensembl ID		ENSG00000151092	ENSG00000100092
Uniprot IDs		Q96IV0	A0A2X0SFX7 Q9Y3L3
PDB IDs		2CCQ 2CM0	4J9D 4J9F
Enriched GO Terms of Interacting Partners?		Polyubiquitin Modification-dependent Protein Binding Ubiquitin Binding Modification-dependent Protein Catabolic Process Proteasome Complex VCP-NSFL1C Complex Negative Regulation Of Protein Localization To Centrosome Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Mitotic Centrosome Separation Positive Regulation Of Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Establishment Of Mitotic Spindle Orientation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Microtubule Cytoskeleton Organization Involved In Mitosis Proteolysis Regulation Of Mitotic Centrosome Separation VCP-NPL4-UFD1 AAA ATPase Complex Establishment Of Spindle Localization Spindle Localization Macromolecule Catabolic Process Positive Regulation Of Cell Cycle HMG Box Domain Binding Regulation Of Protein Localization To Centrosome Positive Regulation Of Proteolysis Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Localization Proteasome Binding Ubiquitin-specific Protease Binding ERAD Pathway Autophagosome Assembly Autophagosome Organization Negative Regulation Of Hippo Signaling Nuclear Membrane Reassembly Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Viral Genome Replication Response To Stress Microtubule-based Process Ubiquitin Protein Ligase Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Catabolic Process Central Nervous System Development Regulation Of Response To Calcium Ion	Positive Regulation Of Organelle Organization Regulation Of Organelle Organization Actin Filament-based Process Cytoskeleton Organization Actin Cytoskeleton Organization Regulation Of Cell-substrate Adhesion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Organelle Organization Substrate Adhesion-dependent Cell Spreading Cell Motility Peptidyl-tyrosine Phosphorylation Regulation Of Lamellipodium Organization Positive Regulation Of Cellular Component Organization Neuron Migration Positive Regulation Of Cellular Component Biogenesis Cell-substrate Adhesion Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Podosome Assembly Regulation Of Actin Cytoskeleton Organization Regulation Of Focal Adhesion Assembly Positive Regulation Of Supramolecular Fiber Organization Cell Migration Positive Regulation Of Cytoskeleton Organization Regulation Of Cell-substrate Junction Organization Regulation Of Actin Filament-based Process Cellular Component Assembly Positive Regulation Of Protein-containing Complex Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Actin Filament Regulation Of Cell Projection Organization Regulation Of Cellular Component Organization Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Protein-containing Complex Assembly Cytoskeleton Ephrin Receptor Binding Positive Regulation Of Vasoconstriction Regulation Of Organelle Assembly Actin Filament Organization Regulation Of Cell Junction Assembly Regulation Of Actin Filament Organization Positive Regulation Of Cell Adhesion Fc-gamma Receptor Signaling Pathway Positive Regulation Of Lamellipodium Organization Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Regulation Of Cytoskeleton Organization Regulation Of Lamellipodium Assembly Negative Regulation Of Telomere Maintenance Regulation Of Synapse Organization
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