COLEC12

Name	collectin subfamily member 12
Structure
Novel Interactors	3 novel interactors: EXOSC2 PTPN2 ZBTB14
Interactors	3 interactors: APP EXOC1 FBXO7
GO Annotations	Cellular Component	Collagen Trimer Plasma Membrane Membrane Endocytic Vesicle Membrane Extracellular Matrix
	Molecular Function	Scavenger Receptor Activity Protein Binding Galactose Binding Low-density Lipoprotein Particle Binding Carbohydrate Binding Pattern Recognition Receptor Activity Metal Ion Binding
	Biological Process	Regulation Of Immune System Process Phagocytosis, Recognition Defense Response Immune Response Carbohydrate Mediated Signaling Defense Response To Bacterium Plasma Membrane Raft Organization Innate Immune Response
Pathways	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Scavenging by Class A Receptors
GWAS	Bipolar disorder ( 20351715 ) Bipolar disorder or major depressive disorder ( 20351715 ) Blood protein levels ( 30072576 ) Coenzyme Q10 levels ( 27149984 ) Metabolic syndrome ( 29212154 ) Obesity-related traits ( 23251661 ) Schizophrenia x sex interaction ( 34099189 ) Smoking status (ever vs never smokers) ( 30643258 )
Entrez ID	81035
HPRD ID	06358
Ensembl ID	ENSG00000158270
Uniprot IDs	Q5KU26
PDB IDs	2OX8
GO Terms Enriched among Interactors ?	Regulation Of Intrinsic Apoptotic Signaling Pathway Endosome Lumen Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Lymphocyte Differentiation Negative Regulation Of Positive Thymic T Cell Selection Negative Regulation Of Interleukin-2-mediated Signaling Pathway Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of Response To Endoplasmic Reticulum Stress Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Integrin Binding Regulation Of Immune System Process Regulation Of Cell Activation Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Positive Regulation Of Apoptotic Signaling Pathway Growth Cone Filopodium Lipoprotein Particle Cytosol Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Leukocyte Activation Positive Regulation Of Protein Import Cell Activation Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Interleukin-4-mediated Signaling Pathway Regulation Of Positive Thymic T Cell Selection Negative Regulation Of Hemopoiesis Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Lewy Body Core Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Positive Regulation Of Small Molecule Metabolic Process Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of PERK-mediated Unfolded Protein Response