ASF1B and HIRA

Number of citations of the paper that reports this interaction (PMID 16980972)
44

Data Source:
BioGRID (pull down, affinity chromatography technology)

		ASF1B	HIRA
Gene Name		anti-silencing function 1B histone chaperone	histone cell cycle regulator
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleoplasm Protein Complex	Nuclear Chromatin Nucleus Nucleoplasm PML Body Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Histone Binding	Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding
	Biological Process	DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Transcription, DNA-templated Regulation Of Transcription, DNA-templated Multicellular Organismal Development Spermatogenesis Chromatin Modification Cell Differentiation	Osteoblast Differentiation DNA Replication-independent Nucleosome Assembly Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Gastrulation Anatomical Structure Morphogenesis Chromatin Modification Muscle Cell Differentiation Negative Regulation Of Nucleic Acid-templated Transcription
Pathways			DNA Damage/Telomere Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Cellular Senescence
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: ASF1A C15orf41 CHAF1A CHAF1B H3F3A HCFC1 HIRA HIST1H3C HIST1H3E HIST1H4F HIST4H4 TAF1 TLK1 TLK2	15 interactors: ASF1A ASF1B CCNA2 CDK2 H3F3B HIRIP3 HIST1H2BD HIST1H2BK HIST2H2BE HNRNPD NFU1 PAX7 SUMO1 UBN1 UPF1
Entrez ID		55723	7290
HPRD ID		16460	02583
Ensembl ID		ENSG00000105011	ENSG00000100084
Uniprot IDs		Q9NVP2	P54198
PDB IDs			2I32
Enriched GO Terms of Interacting Partners?		DNA Replication-dependent Nucleosome Assembly Chromatin Organization Protein-DNA Complex Assembly Nucleosome Assembly Chromosome Organization Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly DNA Packaging DNA Conformation Change DNA Methylation On Cytosine Cellular Macromolecular Complex Assembly Chromatin Silencing At RDNA Organelle Organization DNA Replication-independent Nucleosome Assembly Chromatin Silencing DNA Methylation Chromatin Modification Protein Complex Assembly Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic DNA Modification Gene Silencing Cellular Component Assembly DNA Metabolic Process Gene Expression Cell Cycle Regulation Of Gene Silencing Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone H4-K20 Demethylation Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Methylation Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Response To DNA Damage Stimulus Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Megakaryocyte Differentiation Regulation Of Chromatin Assembly Or Disassembly Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Response To Stress	Chromatin Organization Chromosome Organization Chromatin Assembly Or Disassembly DNA Replication-independent Nucleosome Assembly Nucleosome Assembly Organelle Organization Chromatin Assembly Nucleosome Organization Protein-DNA Complex Assembly DNA Packaging DNA Conformation Change DNA Replication-dependent Nucleosome Assembly Chromatin Modification Cellular Macromolecular Complex Assembly Innate Immune Response In Mucosa Response To Stress Regulation Of Gene Silencing Cellular Response To DNA Damage Stimulus Antibacterial Humoral Response Regulation Of Gene Expression Antimicrobial Humoral Response Mucosal Immune Response Regulation Of Gene Expression, Epigenetic Protein Complex Assembly Regulation Of Transcription, DNA-templated DNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process DNA Repair Regulation Of RNA Metabolic Process Cellular Component Assembly Skeletal Muscle Satellite Cell Commitment Regulation Of Cellular Protein Metabolic Process Defense Response To Gram-positive Bacterium Positive Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Metabolic Process Mitotic DNA Damage Checkpoint Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Mitotic DNA Integrity Checkpoint Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process PML Body Organization Positive Regulation Of DNA-dependent DNA Replication Initiation G2/M Transition Of Mitotic Cell Cycle Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Protein Localization To Nuclear Pore Positive Regulation Of Myoblast Proliferation
Tagcloud ?		aid avenue caf cenp centromeric chaperones clustering dataset decisions discriminate distinguish exploit guide hierarchical hjurp implicating ki67 luminal offers outperforming p150 p60 regulators substratification tools transcriptome unfavorable unsupervised utilized	actively cabin1 caf calcineurin concomitantly constituting coordinated copyright crosses deposit extractable fertility heterochromatic impacts imply inheritance nucleosome occupancy orthologs pericentromeric preserve rescues reserved rights transcribed transposons ubinuclein ubn
Tagcloud (Difference) ?		aid avenue cenp centromeric chaperones clustering dataset decisions discriminate distinguish exploit guide hierarchical hjurp implicating ki67 luminal offers outperforming p150 p60 regulators substratification tools transcriptome unfavorable unsupervised utilized	actively cabin1 calcineurin concomitantly constituting coordinated copyright crosses deposit extractable fertility heterochromatic impacts imply inheritance nucleosome occupancy orthologs pericentromeric preserve rescues reserved rights transcribed transposons ubinuclein ubn
Tagcloud (Intersection) ?		caf