IWS1 and TCEA1

Number of citations of the paper that reports this interaction (PubMedID 16648364)
47

Data Source:
HPRD (in vitro)

		IWS1	TCEA1
Description		interacts with SUPT6H, CTD assembly factor 1	transcription elongation factor A1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Transcription Factor TFIID Complex Nucleolus
	Molecular Function	Protein Binding	Nucleic Acid Binding DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	In Utero Embryonic Development Chromatin Remodeling MRNA Processing RNA Splicing Regulation Of MRNA Export From Nucleus Poly(A)+ MRNA Export From Nucleus Regulation Of MRNA Processing MRNA Transport Transcription Elongation-coupled Chromatin Remodeling	DNA-templated Transcription Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Erythrocyte Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation	Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Cardiac troponin-I levels ( 31014085)	Urinary albumin-to-creatinine ratio ( 26631737)
Interacting Genes		10 interacting genes: AKT1 AKT3 CSNK2A1 ERCC6 ERICH2 KRTAP10-3 POLR2A STAT2 SUPT6H TCEA1	20 interacting genes: APP CDC73 CDK7 CEBPA CIRSR CTDP1 CTR9 EAF2 GPKOW GTF2E1 GTF2F2 IWS1 LEO1 PAF1 POLR2A REXO1 RTF1 SKIC8 SUPT6H UBR5
Entrez ID		55677	6917
HPRD ID		07639	03252
Ensembl ID		ENSG00000163166	ENSG00000187735
Uniprot IDs		A0A1B0GW95 Q96ST2	A0A384MTX4 B7Z4W0 P23193
PDB IDs		6EMR 6ZV1 6ZV4 9EGX 9EGY 9EGZ 9EH0 9EH1 9EH2	1TFI 3NDQ 5IY6 5IY7 5IY8 5IYA 5IYB 5IYC 6O9L 6ZUY 6ZV4 7CNF 7UNC 7UND 8A40 8UIS 9EGX 9EGY 9EGZ 9EH0 9EH1 9EH2 9J0N
Enriched GO Terms of Interacting Partners?		DNA-templated Transcription Elongation Transcription Elongation By RNA Polymerase II Negative Regulation Of PERK-mediated Unfolded Protein Response Double-strand Break Repair Via Classical Nonhomologous End Joining RNA Metabolic Process Regulation Of PERK-mediated Unfolded Protein Response Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of DNA Recombination Sin3-type Complex Transcription Elongation Factor Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Execution Phase Of Apoptosis Regulation Of Peptidyl-serine Phosphorylation Regulation Of DNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Response To Stress Negative Regulation Of Double-strand Break Repair Negative Regulation Of DNA Repair Negative Regulation Of Translational Initiation Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Response To Endoplasmic Reticulum Stress Nucleoplasm Regulation Of TRNA Methylation Positive Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Blood Vessel Endothelial Cell Migration Nucleic Acid Metabolic Process Positive Regulation Of DNA-templated Transcription, Elongation Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Response To Insulin-like Growth Factor Stimulus Regulation Of Blood Vessel Endothelial Cell Migration Protein Serine Kinase Activity Mammalian Oogenesis Stage Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Regulation Of Gene Expression Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Regulation Of Cell Cycle Phase Transition Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Kinase Binding	Transcription Elongation By RNA Polymerase II DNA-templated Transcription Elongation RNA Metabolic Process Cdc73/Paf1 Complex Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Endodermal Cell Fate Commitment Nucleobase-containing Compound Biosynthetic Process Cell Fate Commitment Involved In Formation Of Primary Germ Layer Macromolecule Metabolic Process Macromolecule Biosynthetic Process Nucleoplasm Nucleus MRNA Metabolic Process Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Myeloid Cell Differentiation Regulation Of DNA-templated Transcription Elongation Regulation Of RNA Metabolic Process Stem Cell Population Maintenance Maintenance Of Cell Number Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II MRNA Processing Wnt Signaling Pathway Positive Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Cell Fate Commitment Regulation Of Macromolecule Biosynthetic Process RNA 3'-end Processing RNA Processing Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Myeloid Cell Differentiation Positive Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Complex Binding Negative Regulation Of Developmental Process Regulation Of Hemopoiesis Positive Regulation Of Biosynthetic Process Negative Regulation Of Cell Differentiation MRNA 3'-end Processing Positive Regulation Of RNA Metabolic Process Transcription Initiation At RNA Polymerase II Promoter Regulation Of Primary Metabolic Process Regulation Of Cell Differentiation
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