IWS1 and STAT2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		IWS1	STAT2
Description		interacts with SUPT6H, CTD assembly factor 1	signal transducer and activator of transcription 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane ISGF3 Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Ubiquitin-like Protein Ligase Binding
	Biological Process	In Utero Embryonic Development Chromatin Remodeling MRNA Processing RNA Splicing Regulation Of MRNA Export From Nucleus Poly(A)+ MRNA Export From Nucleus Regulation Of MRNA Processing MRNA Transport Transcription Elongation-coupled Chromatin Remodeling	Regulation Of Protein Phosphorylation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Population Proliferation Response To Peptide Hormone Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Type I Interferon-mediated Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Mitochondrial Fission
Pathways		Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation	Interleukin-20 family signaling Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Regulation of IFNA/IFNB signaling Potential therapeutics for SARS SARS-CoV-2 activates/modulates innate and adaptive immune responses Evasion by RSV of host interferon responses
Drugs
Diseases
GWAS		Cardiac troponin-I levels ( 31014085)	Axial length ( 24144296) Height ( 20881960 23456168 25429064) Inflammatory skin disease ( 25574825) Lymphocyte percentage of white cells ( 32888494) Macular thickness ( 30535121) Psoriasis ( 19169254 23143594 25574825 25903422) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624) Refractive error ( 32231278)
Interacting Genes		10 interacting genes: AKT1 AKT3 CSNK2A1 ERCC6 ERICH2 KRTAP10-3 POLR2A STAT2 SUPT6H TCEA1	22 interacting genes: AURKA CREBBP CXCR4 DOK4 EGFR EP300 FNTA GAA GSK3A GSK3B HDAC1 IFNAR1 IFNAR2 IRF9 IWS1 JAK1 JAK2 MED14 SMARCA4 STAT1 STAT6 TYK2
Entrez ID		55677	6773
HPRD ID		07639	02778
Ensembl ID		ENSG00000163166	ENSG00000170581
Uniprot IDs		A0A1B0GW95 Q96ST2	A0A494C164 P52630 R9QE65
PDB IDs		6EMR 6ZV1 6ZV4 9EGX 9EGY 9EGZ 9EH0 9EH1 9EH2	2KA4 6UX2 6WCZ 8T12 8T13
Enriched GO Terms of Interacting Partners?		DNA-templated Transcription Elongation Transcription Elongation By RNA Polymerase II Negative Regulation Of PERK-mediated Unfolded Protein Response Double-strand Break Repair Via Classical Nonhomologous End Joining RNA Metabolic Process Regulation Of PERK-mediated Unfolded Protein Response Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of DNA Recombination Sin3-type Complex Transcription Elongation Factor Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Execution Phase Of Apoptosis Regulation Of Peptidyl-serine Phosphorylation Regulation Of DNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Response To Stress Negative Regulation Of Double-strand Break Repair Negative Regulation Of DNA Repair Negative Regulation Of Translational Initiation Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Response To Endoplasmic Reticulum Stress Nucleoplasm Regulation Of TRNA Methylation Positive Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Blood Vessel Endothelial Cell Migration Nucleic Acid Metabolic Process Positive Regulation Of DNA-templated Transcription, Elongation Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Response To Insulin-like Growth Factor Stimulus Regulation Of Blood Vessel Endothelial Cell Migration Protein Serine Kinase Activity Mammalian Oogenesis Stage Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Regulation Of Gene Expression Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Regulation Of Cell Cycle Phase Transition Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Kinase Binding	Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization To Nucleus Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Localization Interferon-mediated Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Transcription By RNA Polymerase II Type II Interferon-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Regulation Of Protein Localization Type I Interferon-mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Signal Transduction Regulation Of RNA Metabolic Process Response To Virus Regulation Of Signal Transduction Growth Hormone Receptor Signaling Pathway Cytokine-mediated Signaling Pathway P53 Binding Cellular Response To Cytokine Stimulus Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of DNA-templated Transcription Cellular Response To Virus Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cellular Response To Interleukin-3 Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Growth Hormone Receptor Binding Response To Cytokine Tau Protein Binding Response To Peptide Regulation Of Primary Metabolic Process Positive Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of RNA Metabolic Process Transcription Coactivator Binding Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Developmental Process Regulation Of Cellular Response To Heat Chromatin Remodeling Regulation Of Metabolic Process
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