ZNF280C and CBX5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZNF280C	CBX5
Description		zinc finger protein 280C	chromobox 5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Histone Deacetylase Complex Chromosome, Centromeric Region Kinetochore Chromosome, Telomeric Region Heterochromatin Nucleus Nuclear Envelope Nucleoplasm Chromosome Pericentric Heterochromatin Nucleolus Chromocenter PML Body Transcription Repressor Complex Protein-containing Complex Histone Methyltransferase Complex Site Of DNA Damage Ribonucleoprotein Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Chromatin Binding Protein Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Histone Deacetylase Binding Ribonucleoprotein Complex Binding Protein-containing Complex Binding Histone H3K9me2/3 Reader Activity DNA-binding Transcription Factor Binding Histone Reader Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II DNA Damage Response Heterochromatin Formation Negative Regulation Of DNA-templated Transcription
Pathways			SUMOylation of chromatin organization proteins Transcriptional Regulation by E2F6 Factors involved in megakaryocyte development and platelet production Regulation of endogenous retroelements by KRAB-ZFP proteins
Drugs			Copper
Diseases
GWAS		Height ( 31562340) Reticulocyte count ( 32888494)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Alcohol consumption ( 31358974) Hip circumference ( 28552196) Mean platelet volume ( 22139419) Meat-related diet ( 32066663) Platelet count ( 32888494) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		6 interacting genes: CBX1 CBX5 GOLGA2 HOMEZ KRTAP10-6 TSPYL2	61 interacting genes: ARHGDIA ARL5A BAP1 BARD1 BCL11B BRCA1 CBX1 CBX3 CHAF1A DNMT3B DSN1 ELOA2 ELOC ENO1 FSHR GOLGA8EP H1-4 H1-5 H2AC25 H2BC26 H3-4 H3C1 H3C15 H4C16 HDAC4 HDAC5 HDAC9 HECW2 INCENP ISG15 LAP3 LBR LRIF1 MBD1 MCC MIS12 MKI67 NIPBL NR2F1 NSD3 NSL1 PRR14 RPSA SMARCA4 SP1 SP100 SRPK1 STAM2 SUB1 SUV39H1 TAF4 TRIM24 TRIM28 UBC UBE2A UBE2B VPS28 XRCC6 XRN1 ZNF280C ZNF280D
Entrez ID		55609	23468
HPRD ID		06526	05131
Ensembl ID		ENSG00000056277	ENSG00000094916
Uniprot IDs		Q8ND82	P45973 V9HWG0
PDB IDs			3FDT 3I3C 8UXQ
Enriched GO Terms of Interacting Partners?		Chromocenter Pericentric Heterochromatin Site Of DNA Damage Heterochromatin Chromatin Binding Positive Regulation Of Protein Glycosylation Chromatin Remodeling Heterochromatin Formation Negative Regulation Of Gene Expression, Epigenetic Chromosome, Centromeric Region Chromosome, Telomeric Region Golgi Disassembly Chromatin Organization Regulation Of Protein Glycosylation RDNA Binding Male Pronucleus Nucleolus Golgi Cis Cisterna Golgi Ribbon Formation Importin-alpha Family Protein Binding Female Pronucleus Epigenetic Regulation Of Gene Expression Chromatin Asymmetric Cell Division Meiotic Spindle Assembly Histone Methyltransferase Binding Positive Regulation Of Glycoprotein Biosynthetic Process Histone H3K9me2/3 Reader Activity	Chromatin Organization Chromatin Remodeling Chromosome Nucleus Negative Regulation Of Gene Expression, Epigenetic Nucleoplasm Epigenetic Regulation Of Gene Expression Heterochromatin Formation Chromo Shadow Domain Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Heterochromatin DNA Binding Structural Constituent Of Chromatin Nucleosome Organization Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleosome Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Protein-DNA Complex Assembly Chromosome Segregation Regulation Of Macromolecule Biosynthetic Process Euchromatin Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Nucleosome Assembly Chromatin MIS12/MIND Type Complex Chromosome Organization Histone Deacetylase Binding Regulation Of Transcription By RNA Polymerase II Chromatin Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA Metabolic Process Negative Regulation Of Gene Expression Chromosome, Centromeric Region Chromosome, Telomeric Region DNA Damage Response Histone Deacetylase Activity, Hydrolytic Mechanism Transcription Corepressor Activity Histone H2AK127 Ubiquitin Ligase Activity
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