ITLN1 and LTF

Number of citations of the paper that reports this interaction (PMID 11313366)
41

Data Source:
HPRD (in vitro)

		ITLN1	LTF
Gene Name		intelectin 1 (galactofuranose binding)	lactotransferrin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Anchored Component Of Membrane Brush Border Membrane Receptor Complex Membrane Raft Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Nucleus Secretory Granule Specific Granule Extracellular Vesicular Exosome Phagocytic Vesicle Lumen
	Molecular Function	Carbohydrate Binding	DNA Binding Serine-type Endopeptidase Activity Iron Ion Binding Protein Binding Ferric Iron Binding Heparin Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Response To Nematode Positive Regulation Of Glucose Import	Ossification Regulation Of Cytokine Production Retina Homeostasis Innate Immune Response In Mucosa Transcription, DNA-templated Proteolysis Iron Ion Transport Humoral Immune Response Antibacterial Humoral Response Antifungal Humoral Response Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Tumor Necrosis Factor Production Iron Assimilation By Chelation And Transport Positive Regulation Of Osteoblast Proliferation Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Osteoblast Differentiation Positive Regulation Of NF-kappaB Transcription Factor Activity Interaction With Host Response To Host Immune Response Bone Morphogenesis Positive Regulation Of Protein Serine/threonine Kinase Activity Phagosome Maturation Positive Regulation Of Bone Mineralization Involved In Bone Maturation Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism Positive Regulation Of Chondrocyte Proliferation Negative Regulation Of Tumor Necrosis Factor (ligand) Superfamily Member 11 Production Negative Regulation Of Osteoclast Development
Pathways			Amyloids Phagosomal maturation (early endosomal stage) Latent infection of Homo sapiens with Mycobacterium tuberculosis Response of Mtb to phagocytosis Mtb iron assimilation by chelation
Drugs			3h-Indole-5,6-Diol Alpha-D-Mannose Nitrilotriacetic Acid Alpha-D-Fucose Nimesulide 2-(4-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)PHENYL)ETHANAMIDE parecoxib
Diseases
GWAS		Crohn's disease ( 18587394 21102463) Inflammatory bowel disease ( 23128233)	AIDS progression ( 21502085)
Protein-Protein Interactions		1 interactors: LTF	9 interactors: CALM1 CD14 CEL CP ITLN1 LCN1 LRP1 LYZ MUC7
Entrez ID		55600	4057
HPRD ID		17165	01028
Ensembl ID		ENSG00000179914	ENSG00000012223
Uniprot IDs		Q8WWA0	E7ER44 P02788
PDB IDs			1B0L 1BKA 1CB6 1DSN 1EH3 1FCK 1H43 1H44 1H45 1HSE 1L5T 1LCF 1LCT 1LFG 1LFH 1LFI 1LGB 1N76 1SQY 1U62 1VFD 1VFE 1XV4 1XV7 1Z6V 1Z6W 2BJJ 2DP4 2GMC 2GMD 2HD4 2PMS
Enriched GO Terms of Interacting Partners?		Iron Assimilation By Chelation And Transport Negative Regulation Of Tumor Necrosis Factor (ligand) Superfamily Member 11 Production Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism Negative Regulation Of Osteoclast Development Antifungal Humoral Response Positive Regulation Of Bone Mineralization Involved In Bone Maturation Positive Regulation Of Chondrocyte Proliferation Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Response To Host Immune Response Regulation Of Osteoclast Development Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Osteoblast Proliferation Positive Regulation Of Toll-like Receptor Signaling Pathway Innate Immune Response In Mucosa Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Osteoblast Proliferation Antibacterial Humoral Response Defense Response To Fungus Antimicrobial Humoral Response Negative Regulation Of Osteoclast Differentiation Mucosal Immune Response Response To Fungus Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Bone Mineralization Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Biomineral Tissue Development Phagosome Maturation Negative Regulation Of Myeloid Leukocyte Differentiation Retina Homeostasis Regulation Of Osteoclast Differentiation Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Iron Ion Transport Cellular Iron Ion Homeostasis Negative Regulation Of Myeloid Cell Differentiation Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Ossification Interaction With Host Regulation Of Myeloid Leukocyte Differentiation Iron Ion Homeostasis Bone Morphogenesis Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Osteoblast Differentiation Transition Metal Ion Homeostasis Regulation Of Myeloid Cell Differentiation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Tissue Homeostasis Defense Response To Bacterium Regulation Of Ossification Negative Regulation Of Cytokine Production	Positive Regulation Of Transport Retina Homeostasis Alcohol Metabolic Process Response To External Stimulus Phototransduction, Visible Light Beta-amyloid Clearance Protein Esterification Intestinal Lipid Catabolic Process Regulation Of Phospholipase Activity Detection Of Visible Light Phototransduction Detection Of Light Stimulus Cholesterol Metabolic Process Sterol Metabolic Process Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Multicellular Organismal Lipid Catabolic Process Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of High Voltage-gated Calcium Channel Activity Detection Of Abiotic Stimulus Response To Other Organism Tissue Homeostasis Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Response To Biotic Stimulus Pancreatic Juice Secretion Response To Nematode Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Intestinal Cholesterol Absorption Multicellular Organismal Homeostasis Transport Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Steroid Metabolic Process Phagocytosis Detection Of Calcium Ion Regulation Of Phospholipase A2 Activity Cholesterol Catabolic Process Lipid Digestion Regulation Of Cell Communication By Electrical Coupling Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphoprotein Phosphatase Activity Lipid Transport Cellular Response To Lipoteichoic Acid Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Autophosphorylation Response To Metal Ion Lipid Localization Negative Regulation Of Smooth Muscle Cell Migration Response To Magnesium Ion Positive Regulation Of Nitric-oxide Synthase Activity Response To Abiotic Stimulus
Tagcloud ?		12b 18rap 23r atg16l1 card15 card9 ccr6 crohn dlg5 dmbt1 holds homeostatic ibd5 icoslg irf5 irgm loci lrrk2 mst1 nkx2 orchestration predispose ptger4 ptpn2 ptpn22 tl1a tnfrsf6b tnfsf15 xbp1	ag alox15 basel caries childhood dentition ecc eec enam environmental experience fifty genotypes genotyping gg habits imbalance infectious karger klk4 protective rs1264848 rs198968 rs3790506 rs4547741 rs7217186 tt tuft1 unrelated
Tagcloud (Difference) ?		12b 18rap 23r atg16l1 card15 card9 ccr6 crohn dlg5 dmbt1 holds homeostatic ibd5 icoslg irf5 irgm loci lrrk2 mst1 nkx2 orchestration predispose ptger4 ptpn2 ptpn22 tl1a tnfrsf6b tnfsf15 xbp1	ag alox15 basel caries childhood dentition ecc eec enam environmental experience fifty genotypes genotyping gg habits imbalance infectious karger klk4 protective rs1264848 rs198968 rs3790506 rs4547741 rs7217186 tt tuft1 unrelated
Tagcloud (Intersection) ?