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VEZT and C5
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
50
Data Source:
BioGRID
(two hybrid)
VEZT
C5
Description
vezatin, adherens junctions transmembrane protein
complement C5
Image
No pdb structure
GO Annotations
Cellular Component
Acrosomal Vesicle
Stereocilia Ankle Link Complex
Nucleus
Nucleoplasm
Cytosol
Plasma Membrane
Adherens Junction
Membrane
Cytoplasmic Vesicle
Cell Projection
Stereocilium Membrane
Anchoring Junction
Extracellular Region
Membrane Attack Complex
Extracellular Space
Membrane
Other Organism Cell Membrane
Extracellular Exosome
Transmembrane Transporter Complex
Molecular Function
Myosin Binding
G Protein-coupled Receptor Binding
Endopeptidase Inhibitor Activity
Signaling Receptor Binding
Protein Binding
Chemokine Activity
Receptor Ligand Activity
Biological Process
Cell-cell Adhesion
Complement Activation, Lectin Pathway
Immune System Process
Regulation Of Immune System Process
Chemotaxis
Inflammatory Response
Complement Activation
Complement Activation, Alternative Pathway
Complement Activation, Classical Pathway
Signal Transduction
Cell Surface Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Vascular Endothelial Growth Factor Production
Negative Regulation Of Macrophage Chemotaxis
Cell Migration
Leukocyte Chemotaxis
Killing Of Cells Of Another Organism
Positive Regulation Of Chemokine Production
Innate Immune Response
Regulation Of Chemotaxis
Cell Chemotaxis
Complement Activation, GZMK Pathway
Pathways
Terminal pathway of complement
Activation of C3 and C5
Peptide ligand-binding receptors
G alpha (i) signalling events
Regulation of Complement cascade
Drugs
Human immunoglobulin G
Eculizumab
Zinc
Copper
Ravulizumab
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Zilucoplan
Vilobelimab
Diseases
Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency
GWAS
Brain morphology (MOSTest) (
32665545
)
Endometriosis (
23104006
23472165
28537267
)
Pursuit maintenance gain (
29064472
)
Blood protein levels (
30072576
)
Coronary artery disease (
29212778
)
Hip circumference adjusted for BMI (
25673412
)
Pulse pressure (
27841878
)
Refractive error (
32231278
)
Rheumatoid arthritis (
19503088
24390342
30891314
)
Interacting Genes
16 interacting genes:
ANKS6
AQP6
C5
CMTM3
CREB3L1
GORAB
HSD17B11
LRRC4C
MTIF3
MYO7A
PGRMC2
RMDN2
SACM1L
TLCD4
TMEM201
TSNARE1
22 interacting genes:
ANKS6
AQP6
C2
C3
C5AR1
C6
C7
C8B
CPB2
CPLX4
CPN1
CREB3L1
EBP
KEL
KIR3DL3
LMNA
MMGT1
NEMP1
PGRMC2
POU6F2
SSMEM1
VEZT
Entrez ID
55591
727
HPRD ID
11671
00405
Ensembl ID
ENSG00000028203
ENSG00000106804
Uniprot IDs
Q9HBM0
A0A8Q3SID6
P01031
Q59GS8
PDB IDs
1CFA
1KJS
1XWE
3CU7
3HQA
3HQB
3KLS
3KM9
3PRX
3PVM
4A5W
4E0S
4P39
4UU9
5B4P
5B71
5HCC
5HCD
5HCE
5I5K
6H03
6H04
6RPT
6RQJ
7AD6
7AD7
7NYC
7NYD
7Y64
8B0F
8B0G
8B0H
8HK5
8HQC
8IA2
8JZZ
Enriched GO Terms of Interacting Partners
?
Complement Activation, GZMK Pathway
Complement Activation, Classical Pathway
Complement Activation
Membrane Attack Complex
Other Organism Cell Membrane
Transmembrane Transporter Complex
Killing Of Cells Of Another Organism
Complement Activation, Alternative Pathway
Activation Of Immune Response
Classical-complement-pathway C3/C5 Convertase Complex
Positive Regulation Of Immune Response
Cell Killing
Regulation Of Immune Response
Nuclear Envelope
Immune Effector Process
Positive Regulation Of Apoptotic Cell Clearance
Humoral Immune Response
Regulation Of Apoptotic Cell Clearance
Complement Activation, Lectin Pathway
Activation Of Membrane Attack Complex
Complement Receptor Mediated Signaling Pathway
Regulation Of Immune System Process
Positive Regulation Of Immune System Process
Opsonization
Symbiont Cell Surface
Metallocarboxypeptidase Activity
Amyloid-beta Clearance
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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