ZNF821 and PIM2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		ZNF821	PIM2
Description		zinc finger protein 821	Pim-2 proto-oncogene, serine/threonine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II	G1/S Transition Of Mitotic Cell Cycle Protein Phosphorylation Apoptotic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Population Proliferation Apoptotic Mitochondrial Changes Response To Virus Positive Regulation Of Autophagy Macroautophagy Positive Regulation Of Macroautophagy Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of DNA-templated Transcription Protein Stabilization
Pathways
Drugs
Diseases
GWAS
Interacting Genes		10 interacting genes: ATM CCDC85B CDCA7L DVL3 FXR1 LURAP1 NRIP1 PIM2 RUNDC3A SMARCA2	16 interacting genes: ATXN1 BAD CUTC DAPK1 FBH1 FBP1 FBXO7 GSK3B HNRNPH3 HSF1 IKBKG NDUFB8 RPL21 SOCS1 TRIM14 ZNF821
Entrez ID		55565	11040
HPRD ID		14244	02244
Ensembl ID		ENSG00000102984	ENSG00000102096
Uniprot IDs		A0A087WXX1 A0A0C4DH12 O75541	Q9P1W9
PDB IDs			2IWI 4X7Q
Enriched GO Terms of Interacting Partners?		Germ Cell Development Positive Regulation Of Intracellular Signal Transduction Spermatid Development Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell Communication Protein Stabilization Positive Regulation Of Signaling Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Ovarian Follicle Rupture Reproductive Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Telomerase Catalytic Core Complex Assembly Developmental Process Involved In Reproduction Regulation Of Protein Stability Positive Regulation Of Double-strand Break Repair DNA-dependent Protein Kinase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cell Development Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Metabolic Process Histone H2AXS139 Kinase Activity Positive Regulation Of Macroautophagy Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Metabolic Process Regulation Of Sister Chromatid Segregation Nucleolus Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cellular Response To Nitrosative Stress Pre-B Cell Allelic Exclusion Regulation Of Primary Metabolic Process Regulation Of Chromosome Segregation Peptidyl-serine Autophosphorylation Nucleosome Array Spacer Activity RNA Strand Annealing Activity Nuclear Pore Localization Positive Regulation Of DNA Repair	Positive Regulation Of Autophagy Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Catabolic Process Regulation Of Type B Pancreatic Cell Development Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Autophagy Protein Kinase Binding Regulation Of Cellular Response To Stress Regulation Of Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of Cell Development Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of Cellular Response To Heat Positive Regulation Of Programmed Cell Death Extrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Stress Positive Regulation Of Apoptotic Signaling Pathway Nucleus Regulation Of Macromolecule Metabolic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Hemopoiesis Positive Regulation Of Proteolysis Positive Regulation Of Cell Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Positive Regulation Of Leukocyte Differentiation Positive Regulation Of Cell Differentiation Cellular Response To Lipid DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Regulation Of Microtubule Anchoring At Centrosome Cellular Response To Nitroglycerin Negative Regulation Of DNA Repair Negative Regulation Of Double-strand Break Repair Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of Primary Metabolic Process Regulation Of Lymphocyte Differentiation Negative Regulation Of Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
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