PREP and OXT

Number of citations of the paper that reports this interaction (PubMedID 12173)
0

Data Source:
HPRD (in vitro)

		PREP	OXT
Description		prolyl endopeptidase	oxytocin/neurophysin I prepropeptide
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Membrane	Extracellular Region Extracellular Space Cytoplasm Secretory Granule Terminal Bouton Neuronal Dense Core Vesicle
	Molecular Function	Metallocarboxypeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Oligopeptidase Activity	Hormone Activity Neuropeptide Hormone Activity Neurohypophyseal Hormone Activity Protein Binding Oxytocin Receptor Binding
	Biological Process	Angiotensin Maturation Proteolysis	Response To Amphetamine Regulation Of Heart Rate Maternal Aggressive Behavior Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Heart Development Female Pregnancy Memory Grooming Behavior Response To Sucrose Positive Regulation Of Norepinephrine Secretion Response To Activity Response To Food Positive Regulation Of Prostaglandin Secretion Response To Estradiol Response To Retinoic Acid Response To Progesterone Response To Genistein Response To Prostaglandin E Social Behavior Intracellular Signal Transduction Negative Regulation Of Urine Volume Response To Cocaine Maternal Behavior Sperm Ejaculation Eating Behavior Drinking Behavior Response To Peptide Hormone Response To Ether Negative Regulation Of Blood Pressure Positive Regulation Of Blood Pressure Positive Regulation Of Ossification Positive Regulation Of Female Receptivity Response To Steroid Hormone Positive Regulation Of Synaptic Transmission Response To Glucocorticoid Response To CAMP Response To Electrical Stimulus Positive Regulation Of Synapse Assembly Male Mating Behavior Positive Regulation Of Penile Erection Positive Regulation Of Hindgut Contraction Positive Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Cold-induced Thermogenesis
Pathways			Vasopressin-like receptors G alpha (q) signalling events
Drugs		1-Hydroxy-1-Thio-Glycerol S-oxy-L-cysteine Z-Pro-Prolinal Monothioglycerol (6S)-1-chloro-3-[(4-fluorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)pyrrolo[1,2-a]pyrazin-4(6H)-one 1-{3-oxo-3-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propyl}-3-phenylquinoxalin-2(1H)-one 2-{3-[(2S)-4,4-difluoro-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-3-oxopropyl}-isoindole-1,3(2H)-dione
Diseases
GWAS		Asthma ( 27611488) Beard thickness ( 26926045) Blood protein levels ( 30072576) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Multiple sclerosis ( 31604244) Response to (pegylated) interferon in HBeAG-positive hepatitis B ( 30715261) T wave morphology restitution during exercise ( 31607149) T wave morphology restitution during exercise (MTAG) ( 31607149) Youthful appearance (self-reported) ( 32339537)	Blood protein levels ( 30072576) Serum oxytocin levels ( 31361301)
Interacting Genes		7 interacting genes: AGT BRCA1 KNG1 NTS OXT SNCA TAC1	5 interacting genes: ESR2 KMT2A OXTR PREP TXNDC17
Entrez ID		5550	5020
HPRD ID		02673	08880
Ensembl ID		ENSG00000085377	ENSG00000101405
Uniprot IDs		B2RAH7 P48147	P01178 X5D7M6
PDB IDs		3DDU	7OFG 7OTD 7QVM 7RYC
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Component Biogenesis Blood Vessel Diameter Maintenance Hormone Activity Regulation Of Reactive Oxygen Species Metabolic Process Receptor Ligand Activity Regulation Of Tube Size Regulation Of Lipid Transport Extracellular Region Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Cytosolic Calcium Ion Concentration Antimicrobial Humoral Response Killing Of Cells Of Another Organism Positive Regulation Of Synaptic Transmission Positive Regulation Of Inflammatory Response Regulation Of Blood Pressure Neuronal Dense Core Vesicle Regulation Of Secretion By Cell Cell Killing Regulation Of Heart Contraction Regulation Of Secretion Neuropeptide Hormone Activity Regulation Of Biological Quality Cysteine-type Endopeptidase Inhibitor Activity Extracellular Space System Process Regulation Of Blood Circulation Regulation Of Catecholamine Secretion Terminal Bouton Regulation Of Cell Junction Assembly Vascular Process In Circulatory System Regulation Of Microtubule-based Process Humoral Immune Response Response To Cocaine Regulation Of Multicellular Organismal Process Negative Regulation Of Blood Pressure Positive Regulation Of Secretion By Cell Positive Regulation Of Cell Communication Positive Regulation Of Signaling Circulatory System Process Axon Terminus Positive Regulation Of Secretion Positive Regulation Of Ossification Regulation Of Lipid Metabolic Process Regulation Of Small Molecule Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Response To Activity Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Hindgut Contraction Oxytocin Receptor Binding	Nuclear Estrogen Receptor Activity T-helper 2 Cell Differentiation Unmethylated CpG Binding Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Protein-cysteine Methyltransferase Activity MLL1/2 Complex Negative Regulation Of Heterochromatin Formation Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity Minor Groove Of Adenine-thymine-rich DNA Binding Regulation Of Heterochromatin Formation Maternal Process Involved In Parturition Vasopressin Receptor Activity Oxytocin Receptor Activity Regulation Of Systemic Arterial Blood Pressure By Vasopressin Oligopeptidase Activity Protein-disulfide Reductase [NAD(P)H] Activity Estrogen Response Element Binding
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