PREP

Description		prolyl endopeptidase
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Membrane
	Molecular Function	Metallocarboxypeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Oligopeptidase Activity
	Biological Process	Angiotensin Maturation Proteolysis
Pathways
Drugs		1-Hydroxy-1-Thio-Glycerol S-oxy-L-cysteine Z-Pro-Prolinal Monothioglycerol (6S)-1-chloro-3-[(4-fluorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)pyrrolo[1,2-a]pyrazin-4(6H)-one 1-{3-oxo-3-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propyl}-3-phenylquinoxalin-2(1H)-one 2-{3-[(2S)-4,4-difluoro-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-3-oxopropyl}-isoindole-1,3(2H)-dione
Diseases
GWAS		Asthma ( 27611488) Beard thickness ( 26926045) Blood protein levels ( 30072576) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Multiple sclerosis ( 31604244) Response to (pegylated) interferon in HBeAG-positive hepatitis B ( 30715261) T wave morphology restitution during exercise ( 31607149) T wave morphology restitution during exercise (MTAG) ( 31607149) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		7 interacting genes: AGT BRCA1 KNG1 NTS OXT SNCA TAC1
Entrez ID		5550
HPRD ID		02673
Ensembl ID		ENSG00000085377
Uniprot IDs		B2RAH7 P48147
PDB IDs		3DDU
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Component Biogenesis Blood Vessel Diameter Maintenance Hormone Activity Regulation Of Reactive Oxygen Species Metabolic Process Receptor Ligand Activity Regulation Of Tube Size Regulation Of Lipid Transport Extracellular Region Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Cytosolic Calcium Ion Concentration Antimicrobial Humoral Response Killing Of Cells Of Another Organism Positive Regulation Of Synaptic Transmission Positive Regulation Of Inflammatory Response Regulation Of Blood Pressure Neuronal Dense Core Vesicle Regulation Of Secretion By Cell Cell Killing Regulation Of Heart Contraction Regulation Of Secretion Neuropeptide Hormone Activity Regulation Of Biological Quality Cysteine-type Endopeptidase Inhibitor Activity Extracellular Space System Process Regulation Of Blood Circulation Regulation Of Catecholamine Secretion Terminal Bouton Regulation Of Cell Junction Assembly Vascular Process In Circulatory System Regulation Of Microtubule-based Process Humoral Immune Response Response To Cocaine Regulation Of Multicellular Organismal Process Negative Regulation Of Blood Pressure Positive Regulation Of Secretion By Cell Positive Regulation Of Cell Communication Positive Regulation Of Signaling Circulatory System Process Axon Terminus Positive Regulation Of Secretion Positive Regulation Of Ossification Regulation Of Lipid Metabolic Process Regulation Of Small Molecule Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Response To Activity Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Hindgut Contraction Oxytocin Receptor Binding
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