STT3A

Gene Name		STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Oligosaccharyltransferase Complex Membrane Integral Component Of Membrane
	Molecular Function	Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Protein Binding
	Biological Process	Protein N-linked Glycosylation Via Asparagine Co-translational Protein Modification Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases of glycosylation Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective MOGS causes MOGS-CDG (CDG-2b) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Defective ALG11 causes ALG11-CDG (CDG-1p)
Drugs
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Schizophrenia ( 21926974)
Protein-protein Interactions		6 interactors: CSDE1 HJURP IRAK2 ITM2C SARM1 TMEM173
Entrez ID		3703
HPRD ID		03086
Ensembl ID		ENSG00000134910
Uniprot IDs		B4DJ24 E9PNQ1 P46977
PDB IDs
Enriched GO Terms of Interacting Partners?		Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Positive Regulation Of Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Innate Immune Response Nuclear-transcribed MRNA Catabolic Process, No-go Decay Regulation Of Immune Response Interferon-beta Production Positive Regulation Of Immune System Process Regulation Of Binding Cellular Response To Exogenous DsRNA Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of Protein Import Into Nucleus, Translocation Cellular Response To Interferon-beta Regulation Of Neuron Projection Development Type I Interferon Production Positive Regulation Of Defense Response To Virus By Host Interleukin-1-mediated Signaling Pathway Regulation Of Protein Import Into Nucleus, Translocation Response To Interferon-beta Immune Response-regulating Signaling Pathway Regulation Of Cell Projection Organization Nucleotide-binding Oligomerization Domain Containing Signaling Pathway CENP-A Containing Nucleosome Assembly Regulation Of Neuron Differentiation Regulation Of Defense Response To Virus By Host
Tagcloud ?		acceptor accessory allowed asparagine biosynthetic catalytic cotranslational cysteine duplication evolve folding glycosylated glycosylation magt1 maximize mediating metazoan oligosaccharides oligosaccharyltransferase organisms ost oxidoreductase posttranslocational progress sequentially skipped stt3b summarize traffic