STT3A

Description		STT3 oligosaccharyltransferase complex catalytic subunit A
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Oligosaccharyltransferase Complex Membrane Oligosaccharyltransferase Complex A
	Molecular Function	Oligosaccharyl Transferase Activity Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Metal Ion Binding
	Biological Process	Protein Glycosylation Protein N-linked Glycosylation Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification
Pathways		Asparagine N-linked glycosylation Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane PD-L1(CD274) glycosylation and translocation to plasma membrane
Drugs
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Breast cancer (survival) ( 25890600) Schizophrenia ( 21926974)
Interacting Genes		7 interacting genes: CSDE1 HJURP IRAK2 ITM2C SARM1 STING1 USP40
Entrez ID		3703
HPRD ID		03086
Ensembl ID		ENSG00000134910
Uniprot IDs		P46977
PDB IDs		6S7O 8B6L 8PN9
Enriched GO Terms of Interacting Partners?		Signaling Adaptor Activity NADP+ Nucleosidase Activity Negative Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Extrinsic Component Of Synaptic Membrane NAD+ Nucleosidase Activity Cyclic-di-GMP Binding STING Complex Regulation Of Innate Immune Response Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway NAD+ Catabolic Process 2',3'-cyclic GMP-AMP Binding
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