STT3A and IRAK2

Number of citations of the paper that reports this interaction (PubMedID 21903422)
55

Data Source:
BioGRID (affinity chromatography technology, pull down)

		STT3A	IRAK2
Description		STT3 oligosaccharyltransferase complex catalytic subunit A	interleukin 1 receptor associated kinase 2
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Oligosaccharyltransferase Complex Membrane Oligosaccharyltransferase Complex A	Nucleus Cytoplasm Cytosol Plasma Membrane Endosome Membrane
	Molecular Function	Oligosaccharyl Transferase Activity Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Metal Ion Binding	Nucleotide Binding Protein Kinase Activity Protein Binding ATP Binding Signaling Adaptor Activity Protein Homodimerization Activity Protein Heterodimerization Activity Molecular Adaptor Activity
	Biological Process	Protein Glycosylation Protein N-linked Glycosylation Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification	Regulation Of Cytokine-mediated Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation Inflammatory Response Signal Transduction Canonical NF-kappaB Signal Transduction Toll Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway Intracellular Signal Transduction Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Interleukin-1-mediated Signaling Pathway Response To Interleukin-1
Pathways		Asparagine N-linked glycosylation Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane PD-L1(CD274) glycosylation and translocation to plasma membrane	MyD88:MAL(TIRAP) cascade initiated on plasma membrane NOD1/2 Signaling Pathway TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation MyD88 cascade initiated on plasma membrane
Drugs
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Breast cancer (survival) ( 25890600) Schizophrenia ( 21926974)	Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		7 interacting genes: CSDE1 HJURP IRAK2 ITM2C SARM1 STING1 USP40	20 interacting genes: ARAF HRAS IL1R1 IRAK1 IRAK3 MYD88 PELI1 PELI2 PELI3 SARM1 SMAD2 SMURF1 STT3A TARDBP TICAM2 TIRAP TLR4 TOLLIP TRAF6 ZC3H12A
Entrez ID		3703	3656
HPRD ID		03086	04491
Ensembl ID		ENSG00000134910	ENSG00000134070
Uniprot IDs		P46977	O43187
PDB IDs		6S7O 8B6L 8PN9	3MOP
Enriched GO Terms of Interacting Partners?		Signaling Adaptor Activity NADP+ Nucleosidase Activity Negative Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Extrinsic Component Of Synaptic Membrane NAD+ Nucleosidase Activity Cyclic-di-GMP Binding STING Complex Regulation Of Innate Immune Response Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway NAD+ Catabolic Process 2',3'-cyclic GMP-AMP Binding	Regulation Of Canonical NF-kappaB Signal Transduction MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Toll-like Receptor Signaling Pathway Interleukin-1-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Immune Response Response To Lipopolysaccharide Cell Surface Pattern Recognition Receptor Signaling Pathway Response To Molecule Of Bacterial Origin Positive Regulation Of Gene Expression Positive Regulation Of Cytokine Production Regulation Of Immune Response Immune Response-activating Signaling Pathway Regulation Of Signal Transduction Response To External Biotic Stimulus Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cytokine Production Positive Regulation Of Cell Communication Immune Response-regulating Signaling Pathway Positive Regulation Of Signaling Regulation Of Defense Response Regulation Of Toll-like Receptor 4 Signaling Pathway Response To Other Organism Activation Of Immune Response Response To Interleukin-1 Immune Response-regulating Cell Surface Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Innate Immune Response Lipopolysaccharide-mediated Signaling Pathway Immune System Process Positive Regulation Of Metabolic Process Innate Immune Response-activating Signaling Pathway Positive Regulation Of Innate Immune Response Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Immune System Process Defense Response To Other Organism Defense Response Response To Lipid Regulation Of Type I Interferon Production Innate Immune Response
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