LAPTM4B and NAALADL2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		LAPTM4B	NAALADL2
Description		lysosomal protein transmembrane 4 beta	N-acetylated alpha-linked acidic dipeptidase like 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Early Endosome Plasma Membrane Endosome Membrane Endomembrane System Membrane Late Endosome Membrane Multivesicular Body Membrane Cell Projection Multivesicular Body, Internal Vesicle	Nucleoplasm Membrane
	Molecular Function	Protein Binding Kinase Binding Ubiquitin Protein Ligase Binding Ceramide Binding Phosphatidylinositol Bisphosphate Binding	Protein Binding
	Biological Process	Endosome Organization Endosome Transport Via Multivesicular Body Sorting Pathway Negative Regulation Of Transforming Growth Factor Beta1 Production Regulation Of Lysosomal Membrane Permeability Negative Regulation Of Lysosomal Protein Catabolic Process Regulation Of Lysosome Organization	Response To Bacterium
Pathways
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) QT interval ( 24952745)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Autism spectrum disorder ( 26398136) Beta blocker survival benefit in heart failure with reduced ejection fraction (time to all cause mortality x beta blocker interaction) ( 33012170) Deep ovarian and/or rectovaginal disease with dense adhesions ( 28333195) Familial lung adenocarcinoma ( 29924316) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 23456168) Idiopathic downbeat nystagmus ( 32157568) Influenza A (H1N1) severity ( 26379185) Kawasaki disease ( 19132087) Loneliness ( 27629369) Metabolite levels (MHPG) ( 23319000) Mitochondrial DNA copy number ( 30704525) Number of sexual partners ( 30643258) Priapism in sickle cell disease ( 31668730) Prostate cancer aggressiveness ( 25939597) Rapid automised naming of pictures ( 30741946) Response to alcohol consumption (flushing response) ( 29460428) Sleep duration ( 23728906) Systemic lupus erythematosus ( 21408207) Triglyceride levels in HIV infection ( 33109212)
Interacting Genes		21 interacting genes: BDKRB1 CGRRF1 CTXN3 CYB561A3 EMP1 GJA8 GPX8 IFNAR1 IGFBP5 ISLR2 MTIF3 NAALADL2 NRG1 ODF4 PIP5K1C SCARB2 SLC22A1 SLC22A2 SLC29A2 TMEM86B TRARG1	6 interacting genes: APP GPR25 GRM2 ITM2B LAPTM4B SLC30A3
Entrez ID		55353	254827
HPRD ID		13960	16388
Ensembl ID		ENSG00000104341	ENSG00000177694
Uniprot IDs		Q86VI4	Q58DX5
PDB IDs
Enriched GO Terms of Interacting Partners?		Pyrimidine-containing Compound Transmembrane Transport Neurotransmitter Transmembrane Transporter Activity Pyrimidine Nucleoside Transmembrane Transporter Activity Membrane Neurotransmitter Uptake Acetylcholine Transport Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Spermidine Transmembrane Transporter Activity Putrescine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Purine-containing Compound Transmembrane Transport Spermidine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Quaternary Ammonium Group Transmembrane Transporter Activity Thiamine Transmembrane Transport Xenobiotic Transport Norepinephrine Uptake Xenobiotic Transport Across Blood-brain Barrier Toxin Transmembrane Transporter Activity Polyamine Transmembrane Transport Serotonin Uptake Norepinephrine Transport Prostaglandin Transmembrane Transporter Activity Monoamine Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Catecholamine Uptake Dopamine Uptake Azole Transmembrane Transport Serotonin Transport Quaternary Ammonium Group Transport Prostaglandin Transport Regulation Of Cell Growth Endosome To Plasma Membrane Protein Transport Transport Across Blood-brain Barrier Vitamin Transmembrane Transport Organic Anion Transmembrane Transporter Activity Neurotransmitter Transport Dopamine Transport Neurotransmitter Reuptake Cellular Detoxification Xenobiotic Transmembrane Transporter Activity Monoamine Transport Regulation Of Growth Import Into Cell Plasma Membrane Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Apical Plasma Membrane	Astrocyte Projection Endosome Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Amyloid-beta Complex Glutamate Receptor Signaling Pathway Growth Cone Lamellipodium Neuron Projection Plasma Membrane Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Zinc Ion Import Into Synaptic Vesicle Lysosome Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Group II Metabotropic Glutamate Receptor Activity Hippocampal Mossy Fiber Regulation Of Lysosomal Membrane Permeability Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Adult Behavior Cellular Response To Norepinephrine Stimulus G Protein-coupled Receptor Signaling Pathway Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Late Endosome Membrane Zinc Ion Import Into Lysosome Negative Regulation Of Lysosomal Protein Catabolic Process Multivesicular Body, Internal Vesicle Regulation Of Spontaneous Synaptic Transmission Regulation Of Synaptic Plasticity NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Intracellular Glutamate Homeostasis
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?