LAPTM4B and SCARB2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LAPTM4B	SCARB2
Description		lysosomal protein transmembrane 4 beta	scavenger receptor class B member 2
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Early Endosome Plasma Membrane Endosome Membrane Endomembrane System Membrane Late Endosome Membrane Multivesicular Body Membrane Cell Projection Multivesicular Body, Internal Vesicle	Golgi Membrane Lysosome Lysosomal Membrane Endoplasmic Reticulum Membrane Plasma Membrane Focal Adhesion Endosome Membrane Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Lysosomal Lumen Extracellular Exosome
	Molecular Function	Protein Binding Kinase Binding Ubiquitin Protein Ligase Binding Ceramide Binding Phosphatidylinositol Bisphosphate Binding	Virus Receptor Activity Phosphatidylserine Binding Transmembrane Signaling Receptor Activity Scavenger Receptor Activity Protein Binding Cholesterol Binding Enzyme Binding Phosphatidylcholine Binding Cargo Receptor Activity Protein Homodimerization Activity Protein-folding Chaperone Binding
	Biological Process	Endosome Organization Endosome Transport Via Multivesicular Body Sorting Pathway Negative Regulation Of Transforming Growth Factor Beta1 Production Regulation Of Lysosomal Membrane Permeability Negative Regulation Of Lysosomal Protein Catabolic Process Regulation Of Lysosome Organization	Protein Targeting To Lysosome Receptor-mediated Endocytosis Sensory Perception Of Sound Positive Regulation Of Neuron Projection Development Aminophospholipid Transport Regulation Of Carbohydrate Catabolic Process Symbiont Entry Into Host Cell Endosome To Plasma Membrane Protein Transport Regulation Of Endosome Organization Regulation Of Lysosome Organization Regulation Of Glucosylceramide Catabolic Process
Pathways			Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases			Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Metabolite levels ( 23823483) QT interval ( 24952745)	BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Estimated glomerular filtration rate ( 31015462) Hippocampal volume ( 29274321) Parkinson's disease ( 21738487 25064009) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		21 interacting genes: BDKRB1 CGRRF1 CTXN3 CYB561A3 EMP1 GJA8 GPX8 IFNAR1 IGFBP5 ISLR2 MTIF3 NAALADL2 NRG1 ODF4 PIP5K1C SCARB2 SLC22A1 SLC22A2 SLC29A2 TMEM86B TRARG1	10 interacting genes: AP3S1 AP3S2 CLDN19 ERGIC3 GPR37L1 GPX8 HIBADH LAPTM4B LMNA THBS1
Entrez ID		55353	950
HPRD ID		13960	03772
Ensembl ID		ENSG00000104341	ENSG00000138760
Uniprot IDs		Q86VI4	A0A1W2PRF6 Q14108
PDB IDs			4F7B 4Q4B 4Q4F 4TVZ 4TW0 4TW2 5UPH 5XBM 6I2K
Enriched GO Terms of Interacting Partners?		Pyrimidine-containing Compound Transmembrane Transport Neurotransmitter Transmembrane Transporter Activity Pyrimidine Nucleoside Transmembrane Transporter Activity Membrane Neurotransmitter Uptake Acetylcholine Transport Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Spermidine Transmembrane Transporter Activity Putrescine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Purine-containing Compound Transmembrane Transport Spermidine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Quaternary Ammonium Group Transmembrane Transporter Activity Thiamine Transmembrane Transport Xenobiotic Transport Norepinephrine Uptake Xenobiotic Transport Across Blood-brain Barrier Toxin Transmembrane Transporter Activity Polyamine Transmembrane Transport Serotonin Uptake Norepinephrine Transport Prostaglandin Transmembrane Transporter Activity Monoamine Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Catecholamine Uptake Dopamine Uptake Azole Transmembrane Transport Serotonin Transport Quaternary Ammonium Group Transport Prostaglandin Transport Regulation Of Cell Growth Endosome To Plasma Membrane Protein Transport Transport Across Blood-brain Barrier Vitamin Transmembrane Transport Organic Anion Transmembrane Transporter Activity Neurotransmitter Transport Dopamine Transport Neurotransmitter Reuptake Cellular Detoxification Xenobiotic Transmembrane Transporter Activity Monoamine Transport Regulation Of Growth Import Into Cell Plasma Membrane Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Apical Plasma Membrane	Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Synaptic Vesicle Coating AP-3 Adaptor Complex Anterograde Synaptic Vesicle Transport Synaptic Vesicle Recycling Melanosome Assembly Golgi To Vacuole Transport Platelet Dense Granule Organization Membrane Coat Vesicle Cargo Loading Synaptic Vesicle Transport Vesicle Coating Melanosome Organization Pigment Granule Organization Vesicle Transport Along Microtubule Anterograde Axonal Transport Intracellular Transport Establishment Of Organelle Localization Vesicle Cytoskeletal Trafficking Golgi Vesicle Transport Axon Cytoplasm 3-hydroxyisobutyrate Dehydrogenase Activity Axonal Transport Vesicle Organization Secretory Granule Organization Early Endosome Cellular Localization Axo-dendritic Transport Establishment Of Localization In Cell Organelle Transport Along Microtubule DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Negative Regulation Of Nitric Oxide Mediated Signal Transduction Collagen V Binding Prosaposin Receptor Activity Retrograde Transporter Complex, Golgi To ER Regulation Of Lysosomal Membrane Permeability Mesaxon Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Post-Golgi Vesicle-mediated Transport Establishment Of Vesicle Localization Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Organelle Localization Vesicle Localization Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Transporter Complex Regulation Of Transepithelial Transport AP-type Membrane Coat Adaptor Complex
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