C4orf19 and EIF3E

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		C4orf19	EIF3E
Gene Name		chromosome 4 open reading frame 19	eukaryotic translation initiation factor 3, subunit E
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component		Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex PML Body Eukaryotic 48S Preinitiation Complex Extracellular Vesicular Exosome
	Molecular Function		Translation Initiation Factor Activity Protein Binding Poly(A) RNA Binding Protein N-terminus Binding
	Biological Process		Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process Negative Regulation Of Translational Initiation
Pathways			Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression
Drugs
Diseases
GWAS			Dupuytren's disease ( 21732829)
Protein-Protein Interactions		2 interactors: EIF3E PDCD10	25 interactors: ATM C4orf19 COPS6 COPS7A COPS7B COPS8 DDX24 EIF3C EIF3L EIF4ENIF1 EPAS1 GPAA1 GPBP1L1 HAP1 IFIT1 NDRG1 NPM1 NSF PRRC2A RUNDC3A SHBG SMAD9 TRIM27 TRIM55 TRIM63
Entrez ID		55286	3646
HPRD ID		07725	03734
Ensembl ID		ENSG00000154274	ENSG00000104408
Uniprot IDs		Q8IY42	B3KW56 P60228
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Golgi Reassembly Posttranscriptional Regulation Of Gene Expression Establishment Of Golgi Localization Golgi Inheritance Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Golgi Localization Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Sprouting Angiogenesis Negative Regulation Of Translational Initiation Negative Regulation Of Blood Vessel Endothelial Cell Migration Formation Of Translation Preinitiation Complex Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Endothelial Cell Proliferation Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Gene Expression Wound Healing, Spreading Of Cells Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Epithelial Cell Migration Cellular Response To Hydrogen Peroxide Morphogenesis Of An Epithelial Sheet Regulation Of Notch Signaling Pathway Regulation Of Translational Initiation Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Component Assembly Golgi Organization Negative Regulation Of Angiogenesis Regulation Of Cellular Protein Metabolic Process Regulation Of Endothelial Cell Proliferation Negative Regulation Of Translation Protein Stabilization Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cellular Response To Reactive Oxygen Species Regulation Of Protein Metabolic Process Regulation Of Peptidyl-serine Phosphorylation Regulation Of Endothelial Cell Migration Response To Hydrogen Peroxide Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Protein Stability Regulation Of Epithelial Cell Migration Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process	Cullin Deneddylation Protein Deneddylation Protein Modification By Small Protein Removal Cellular Response To Organic Cyclic Compound Response To Hypoxia Formation Of Translation Preinitiation Complex Ribonucleoprotein Complex Assembly Cellular Response To DsRNA Signaling Cell Communication Posttranscriptional Regulation Of Gene Expression Cellular Protein Metabolic Process Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Positive Regulation Of Neurotrophin Production Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA Positive Regulation Of Nonmotile Primary Cilium Assembly Primary Spermatocyte Growth Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Process Response To Organic Cyclic Compound Signal Transduction Protein Localization Protein Transport Cellular Protein Modification Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Response To DNA Damage Stimulus Cell Aging Negative Regulation Of Interleukin-2 Secretion Golgi Vesicle Docking Establishment Of Protein Localization Regulation Of Translational Initiation Regulation Of Translation Telomere Maintenance Response To DsRNA Positive Regulation Of Cell Cycle Negative Regulation Of Viral Process DNA Damage Response, Signal Transduction By P53 Class Mediator Double-strand Break Repair Via Homologous Recombination Recombinational Repair Positive Regulation Of Cilium Assembly Regulation Of Ribonuclease Activity Negative Regulation Of Helicase Activity Regulation Of Endodeoxyribonuclease Activity Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Metabolic Process Response To Abiotic Stimulus Regulation Of Protein Metabolic Process Aging
Tagcloud ?			adjacent classification clonality colon contained distant elucidated eukaryotic histopathologic initiation invasion involvement lymph mammalian metastasis microarray mucosa multivariate node paired predict prognosis promoted significance tma translation translational univariate vessel
Tagcloud (Difference) ?			adjacent classification clonality colon contained distant elucidated eukaryotic histopathologic initiation invasion involvement lymph mammalian metastasis microarray mucosa multivariate node paired predict prognosis promoted significance tma translation translational univariate vessel
Tagcloud (Intersection) ?