UQCC1 and BRCA2

Number of citations of the paper that reports this interaction (PubMedID 19578754)
0

Data Source:
BioGRID (pull down)

		UQCC1	BRCA2
Description		ubiquinol-cytochrome c reductase complex assembly factor 1	BRCA2 DNA repair associated
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Cytoplasmic Vesicle	Nuclear Ubiquitin Ligase Complex Chromosome, Telomeric Region Lateral Element Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytosol Cytoskeleton Secretory Granule Protein-containing Complex BRCA2-MAGE-D1 Complex DNA Repair Complex
	Molecular Function	Protein Binding	Protease Binding DNA Binding Single-stranded DNA Binding Histone Acetyltransferase Activity Protein Binding Histone H3 Acetyltransferase Activity Histone H4 Acetyltransferase Activity Identical Protein Binding Gamma-tubulin Binding
	Biological Process	Mitochondrial Respiratory Chain Complex III Assembly	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination Oocyte Maturation Inner Cell Mass Cell Proliferation DNA Repair Nucleotide-excision Repair Double-strand Break Repair DNA Recombination Chromatin Remodeling Regulation Of DNA-templated Transcription DNA Damage Response Male Meiosis I Spermatogenesis Brain Development Cell Population Proliferation Female Gonad Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To X-ray Response To UV-C Response To Gamma Radiation Hemopoiesis DNA Damage Response, Signal Transduction By P53 Class Mediator Replication Fork Processing Regulation Of Cytokinesis Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Chordate Embryonic Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of Mitotic Cell Cycle Chromosome Organization Centrosome Duplication Establishment Of Protein Localization To Telomere Hematopoietic Stem Cell Proliferation Cellular Response To Ionizing Radiation Stem Cell Proliferation Cellular Senescence Mitotic Recombination-dependent Replication Fork Processing Regulation Of DNA Damage Checkpoint
Pathways		Complex III assembly	HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 translocation to the nucleus Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2 Impaired BRCA2 binding to SEM1 (DSS1)
Drugs
Diseases			Ovarian cancer Fanconi anemia Breast cancer Pancreatic cancer
GWAS		Brain morphology (MOSTest) ( 32665545) FEV1 ( 30804560) Fish- and plant-related diet ( 32066663) Height ( 28552196 34270706) Hip circumference adjusted for BMI ( 34021172) Lung function (FVC) ( 30175238 30804560) Neonatal white matter microstructure ( 33009551) Peak expiratory flow ( 30804560) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Apolipoprotein B levels ( 32203549) Basal cell carcinoma ( 31174203) Breast cancer ( 23535733 23535729 29059683) Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Cutaneous squamous cell carcinoma ( 32041948) Keratinocyte cancer (MTAG) ( 31174203) LDL cholesterol ( 24097068) LDL cholesterol levels ( 32203549 28334899) Lung cancer ( 28604730 24880342) Lung cancer in ever smokers ( 28604730) Small cell lung carcinoma ( 28604730) Squamous cell carcinoma ( 31174203) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		1 interacting genes: BRCA2	47 interacting genes: ATR BCCIP BRCA1 BUB1B CCNA1 CCNA2 CCND1 CCNE1 CDK1 CDK2 CFAP52 CHEK1 CHEK2 DMC1 DYNC1LI1 DYNC1LI2 EMSY ERCC5 FANCD2 FANCE FANCG FANCI FLNA H2AX HMG20B HNRNPC KAT2B LIMD1 MAGED1 PALB2 PDS5B PLEC PLK1 RAD51 RNASEH2A RPA1 SEM1 SERPINH1 SMAD3 STAT5A TP53 TP53BP1 UQCC1 USP11 USP21 WTIP XPO1
Entrez ID		55245	675
HPRD ID		12770	02554
Ensembl ID		ENSG00000101019	ENSG00000139618
Uniprot IDs		B7Z314 Q3KRB6 Q9NVA1	A0A7P0T9D7 A0A8V8TPZ2 P51587
PDB IDs			1N0W 3EU7 6GY2 6HQU 7BDX 7LDG 8BR9 8C3J 8C3N 8PBC 8PBD 8QQE 8R2G 8UVW
Enriched GO Terms of Interacting Partners?		Mitotic Recombination-dependent Replication Fork Processing BRCA2-MAGE-D1 Complex Developmental Maturation Nuclear Ubiquitin Ligase Complex Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Hair Follicle Maturation Establishment Of Protein Localization To Telomere Histone H3 Acetyltransferase Activity Lateral Element Telomere Maintenance Via Recombination Regulation Of Mammary Gland Epithelial Cell Proliferation Inner Cell Mass Cell Proliferation Response To UV-C DNA Repair Complex Histone H4 Acetyltransferase Activity Cul4A-RING E3 Ubiquitin Ligase Complex Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Centrosome Duplication Mitotic Recombination Oocyte Maturation Regulation Of DNA Damage Checkpoint Male Meiosis I Female Gonad Development Response To X-ray Hematopoietic Stem Cell Proliferation Cul4-RING E3 Ubiquitin Ligase Complex Histone Acetyltransferase Activity Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Gamma-tubulin Binding Replication Fork Processing Meiosis I DNA Damage Response, Signal Transduction By P53 Class Mediator Nucleotide-excision Repair Response To Gamma Radiation Male Meiotic Nuclear Division Phosphatase Binding Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Senescence Meiosis I Cell Cycle Process Meiotic Nuclear Division Stem Cell Proliferation Cellular Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Hair Cycle Process Regulation Of Cytokinesis Calcium Channel Activity Nuclear Division Telomere Maintenance Signal Transduction By P53 Class Mediator Secretory Granule	DNA Repair DNA Metabolic Process DNA Damage Response DNA Damage Checkpoint Signaling Cellular Response To Stress Double-strand Break Repair Nucleoplasm Nucleic Acid Metabolic Process Signal Transduction In Response To DNA Damage Negative Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Phase Transition Response To Stress Mitotic DNA Damage Checkpoint Signaling Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle Cell Cycle Phase Transition Nucleus Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Chromosome, Telomeric Region Regulation Of Mitotic Cell Cycle Protein Localization To Site Of Double-strand Break G2/M Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination Chromosome Organization Recombinational Repair Response To Ionizing Radiation Cell Cycle G2/M Phase Transition Chromosome DNA Repair Complex Regulation Of DNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Organelle Organization Regulation Of Cell Cycle G2/M Phase Transition Interstrand Cross-link Repair Regulation Of Mitotic Cell Cycle Phase Transition Condensed Nuclear Chromosome Centrosome DNA Recombination Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Localization To Chromosome Regulation Of Chromosome Organization Cyclin A2-CDK2 Complex Response To Radiation Damaged DNA Binding
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