PLEKHG6 and CEP55

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLEKHG6	CEP55
Description		pleckstrin homology and RhoGEF domain containing G6	centrosomal protein 55
Image		No pdb structure
GO Annotations	Cellular Component	Spindle Pole Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Microvillus Cell Junction Cleavage Furrow Cell Projection	Cytoplasm Centrosome Centriole Cytoskeleton Membrane Midbody Cleavage Furrow Intercellular Bridge Flemming Body
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Regulation Of Small GTPase Mediated Signal Transduction	Mitotic Cytokinesis Nucleus Organization Mitotic Metaphase Chromosome Alignment Establishment Of Protein Localization Cell Division Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Midbody Abscission Cranial Skeletal System Development
Pathways		RHOA GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Colorectal cancer ( 24836286) Colorectal cancer or advanced adenoma ( 30510241) Lung cancer ( 31577861) Obesity-related traits ( 23251661) Primary biliary cholangitis ( 26394269)	High density lipoprotein cholesterol levels ( 30498476) Metabolite levels ( 23823483)
Interacting Genes		3 interacting genes: CEP55 RAC1 RHOA	94 interacting genes: AIRIM AKAP9 ANXA11 ARHGEF15 BAG4 C1orf216 CBY2 CCBE1 CCDC120 CCHCR1 CDC37 CDC45 CDK1 CDSN CEP57L1 CFTR COL8A1 CPSF7 DTNB ECSIT EIF1AD ENKD1 ESS2 EXOSC5 FAM161B FAM90A1 FBF1 FXR2 GOLGA2 GOLGA8DP HAUS1 HGS HNRNPA0 HSF2BP KANK2 KIFC3 KRT31 LENG1 LGALS4 LRRC23 MAPK1 MAPK1IP1L MFAP1 MIA3 MORF4L2 NDEL1 NEDD4L NOS3 NTAQ1 NXF1 OGT PCNT PDCD6IP PEF1 PIN1 PLEKHG6 PLK1 POLM POM121 PPP1R16B PRPF6 PSEN2 PSMC2 PTPN23 PWWP3A RAB3D RBM14 RBM17 RBM22 RBM42 RBPMS RCOR3 RNF32 SDCBP SF1 SFPQ SNRPB SNRPN SNW1 SS18L1 SUPT5H TCL1A TEAD4 TEX11 TFG TFIP11 TP53BP2 TSG101 UBC VPS37C VPS37D WASHC1 WASHC3 ZNF48
Entrez ID		55200	55165
HPRD ID		07692	12569
Ensembl ID		ENSG00000008323	ENSG00000138180
Uniprot IDs		A0A2X0TW08 F5H731 Q3KR16	Q53EZ4
PDB IDs			3E1R 3WUT 3WUU 3WUV
Enriched GO Terms of Interacting Partners?		Telencephalon Cell Migration Cytokinetic Process Cerebral Cortex Cell Migration Semaphorin-plexin Signaling Pathway Substrate Adhesion-dependent Cell Spreading Mitotic Cytokinetic Process Forebrain Cell Migration Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Invagination Cleavage Furrow Positive Regulation Of Stress Fiber Assembly Non-canonical Wnt Signaling Pathway Ficolin-1-rich Granule Membrane Positive Regulation Of Actin Filament Bundle Assembly Mitotic Cytokinesis Regulation Of Focal Adhesion Assembly G Protein Activity Membrane Organization Regulation Of Cell-substrate Junction Organization Cytoskeleton-dependent Cytokinesis Regulation Of Stress Fiber Assembly Secretory Granule Membrane Ruffle Membrane Cell-matrix Adhesion Regulation Of Cell-matrix Adhesion Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Cleavage Furrow Formation Regulation Of Reactive Oxygen Species Metabolic Process Neuron Migration Positive Regulation Of Leukocyte Migration Cell-cell Junction Organization Positive Regulation Of Cytoskeleton Organization Lamellipodium Aortic Valve Formation Regulation Of Neuron Differentiation Cell-substrate Adhesion Positive Regulation Of Supramolecular Fiber Organization Cell Cortex Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Vascular Associated Smooth Muscle Contraction Cell Morphogenesis Establishment Or Maintenance Of Cell Polarity Endothelial Tube Lumen Extension Midbody Skeletal Muscle Satellite Cell Migration Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Protein Binding Spliceosomal Complex Centrosome MRNA Processing Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway RNA Splicing Nucleoplasm MRNA Metabolic Process Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Catalytic Step 2 Spliceosome Cytoskeleton Multivesicular Body Assembly Multivesicular Body Organization Positive Regulation Of Exosomal Secretion Late Endosome To Vacuole Transport Organelle Organization Regulation Of Exosomal Secretion Regulation Of Extracellular Exosome Assembly Endosome Transport Via Multivesicular Body Sorting Pathway RNA Processing Calcium-dependent Protein Binding RNA Binding Viral Budding Via Host ESCRT Complex Multivesicular Body Sorting Pathway Positive Regulation Of Exocytosis Viral Budding MRNA Binding Protein Localization To Vacuole Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Cellular Component Assembly Nucleic Acid Metabolic Process Microtubule Nucleation Cytosol Establishment Of Protein Localization To Vacuole ESCRT I Complex Centriole Cytoplasm Spindle Nucleic Acid Binding U4/U6 X U5 Tri-snRNP Complex Microtubule Cytoskeleton Organization Involved In Mitosis MRNA Cis Splicing, Via Spliceosome SnRNP Binding Endosome Organization Microtubule Organizing Center Organization Membrane Fission Microtubule-based Process Organelle Assembly
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