PLEKHG6

Description		pleckstrin homology and RhoGEF domain containing G6
Image		No pdb structure
GO Annotations	Cellular Component	Spindle Pole Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Microvillus Cell Junction Cleavage Furrow Cell Projection
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Regulation Of Small GTPase Mediated Signal Transduction
Pathways		RHOA GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Colorectal cancer ( 24836286) Colorectal cancer or advanced adenoma ( 30510241) Lung cancer ( 31577861) Obesity-related traits ( 23251661) Primary biliary cholangitis ( 26394269)
Interacting Genes		3 interacting genes: CEP55 RAC1 RHOA
Entrez ID		55200
HPRD ID		07692
Ensembl ID		ENSG00000008323
Uniprot IDs		A0A2X0TW08 F5H731 Q3KR16
PDB IDs
Enriched GO Terms of Interacting Partners?		Telencephalon Cell Migration Cytokinetic Process Cerebral Cortex Cell Migration Semaphorin-plexin Signaling Pathway Substrate Adhesion-dependent Cell Spreading Mitotic Cytokinetic Process Forebrain Cell Migration Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Invagination Cleavage Furrow Positive Regulation Of Stress Fiber Assembly Non-canonical Wnt Signaling Pathway Ficolin-1-rich Granule Membrane Positive Regulation Of Actin Filament Bundle Assembly Mitotic Cytokinesis Regulation Of Focal Adhesion Assembly G Protein Activity Membrane Organization Regulation Of Cell-substrate Junction Organization Cytoskeleton-dependent Cytokinesis Regulation Of Stress Fiber Assembly Secretory Granule Membrane Ruffle Membrane Cell-matrix Adhesion Regulation Of Cell-matrix Adhesion Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Cleavage Furrow Formation Regulation Of Reactive Oxygen Species Metabolic Process Neuron Migration Positive Regulation Of Leukocyte Migration Cell-cell Junction Organization Positive Regulation Of Cytoskeleton Organization Lamellipodium Aortic Valve Formation Regulation Of Neuron Differentiation Cell-substrate Adhesion Positive Regulation Of Supramolecular Fiber Organization Cell Cortex Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Vascular Associated Smooth Muscle Contraction Cell Morphogenesis Establishment Or Maintenance Of Cell Polarity Endothelial Tube Lumen Extension Midbody Skeletal Muscle Satellite Cell Migration Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration
Tagcloud ?