UBXN2B

Description		UBX domain protein 2B
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GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Centrosome Cytosol Cytoskeleton Spindle Pole Centrosome
	Molecular Function	Protein Binding Ubiquitin Binding
	Biological Process	Autophagosome Assembly Establishment Of Mitotic Spindle Orientation Golgi Organization Nuclear Membrane Reassembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Centrosome Separation Membrane Fusion Negative Regulation Of Protein Localization To Centrosome
Pathways
Drugs
Diseases
GWAS		Gallstone disease ( 27094239) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Loneliness ( 27629369) Low density lipoprotein cholesterol levels ( 29403010 33339817) Medication use (HMG CoA reductase inhibitors) ( 31015401) Narcolepsy with cataplexy ( 23496005) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Total cholesterol levels ( 29403010 33339817) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		16 interacting genes: CRX INCA1 MEOX1 MEOX2 NGLY1 PAX5 PAX6 PIN1 PPP1R11 PPP1R3A PPP1R7 UBC UBXN6 VAT1L VCP XAF1
Entrez ID		137886
HPRD ID		18973
Ensembl ID		ENSG00000215114
Uniprot IDs		E5RJ36 Q14CS0
PDB IDs		8B5R
Enriched GO Terms of Interacting Partners?		Somite Specification Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nucleus HMG Box Domain Binding Segment Specification Somite Development DNA-binding Transcription Factor Activity Protein Phosphatase 1 Binding Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Cis-trans Isomerase Activity Flavin Adenine Dinucleotide Catabolic Process Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Sorting Pathway Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Retina Development In Camera-type Eye Sclerotome Development Embryonic Pattern Specification Cerebral Cortex Development Habenula Development Pallium Development Ubiquitin Protein Ligase Binding Protein Peptidyl-prolyl Isomerization Phosphothreonine Residue Binding Modification-dependent Protein Catabolic Process VCP-NSFL1C Complex Cellular Response To Arsenite Ion Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Endosome To Lysosome Transport Mitotic Spindle Disassembly Positive Regulation Of Oxidative Phosphorylation Positive Regulation Of Protein K63-linked Deubiquitination Regulation Of Asymmetric Cell Division Oligodendrocyte Cell Fate Specification Proteolysis Cytoplasm Protein Quality Control ERAD Pathway
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