MOCOS and PARVA

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		MOCOS	PARVA
Gene Name		molybdenum cofactor sulfurase	parvin, alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Cytosol	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc Lamellipodium
	Molecular Function	Mo-molybdopterin Cofactor Sulfurase Activity Transferase Activity Lyase Activity Molybdenum Ion Binding Pyridoxal Phosphate Binding	Actin Binding Protein Binding
	Biological Process	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Mo-molybdopterin Cofactor Biosynthetic Process Molybdopterin Cofactor Biosynthetic Process Molybdopterin Cofactor Metabolic Process Small Molecule Metabolic Process	Sprouting Angiogenesis Outflow Tract Septum Morphogenesis Establishment Or Maintenance Of Cell Polarity Regulation Of Cell Shape Actin Cytoskeleton Reorganization Heterotypic Cell-cell Adhesion Cell Junction Assembly Substrate Adhesion-dependent Cell Spreading Cilium Morphogenesis Actin-mediated Cell Contraction Smooth Muscle Cell Chemotaxis
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective CUBN causes hereditary megaloblastic anemia 1 Molybdenum cofactor biosynthesis Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism Defects in cobalamin (B12) metabolism	Cell junction organization Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions
Drugs
Diseases
GWAS			Mortality among heart failure patients ( 20400778)
Protein-Protein Interactions		1 interactors: PARVA	10 interactors: ACTA1 APP ILK LIMS1 MAP2K1 MLH1 MOCOS PXN UBC UBE3A
Entrez ID		55034	55742
HPRD ID		17585	16283
Ensembl ID
Uniprot IDs		Q96EN8	J3KNQ4 Q9NVD7
PDB IDs			2K2R 2VZC 2VZD 2VZG 2VZI 3KMU 3KMW 3REP
Enriched GO Terms of Interacting Partners?		Smooth Muscle Cell Chemotaxis Outflow Tract Septum Morphogenesis Heterotypic Cell-cell Adhesion Smooth Muscle Cell Migration Muscle Cell Migration Substrate Adhesion-dependent Cell Spreading Actin-mediated Cell Contraction Sprouting Angiogenesis Cardiac Septum Morphogenesis Outflow Tract Morphogenesis Actin Filament-based Movement Actin Cytoskeleton Reorganization Cardiac Septum Development Cardiac Chamber Development Regulation Of Cell Shape Cell Chemotaxis Establishment Or Maintenance Of Cell Polarity Cell Junction Assembly Cell-substrate Adhesion Cilium Morphogenesis Heart Morphogenesis Angiogenesis	Positive Regulation Of MAP Kinase Activity Cellular Component Assembly Cell Aging Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Signal Transduction Regulation Of MAP Kinase Activity Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Positive Regulation Of Gene Expression Protein Heterooligomerization Positive Regulation Of MAPK Cascade Activation Of MAPK Activity Regulation Of Signal Transduction Positive Regulation Of Protein Kinase Activity Protein Complex Assembly Cell Development Positive Regulation Of Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Phosphorylation ERBB Signaling Pathway Cell-matrix Adhesion Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Transferase Activity Response To Transforming Growth Factor Beta Cellular Response To Growth Factor Stimulus Cell Junction Assembly Intracellular Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Response To Growth Factor Cellular Response To Stimulus Cell-substrate Adhesion Multicellular Organismal Development Regulation Of MAPK Cascade Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Anatomical Structure Development Positive Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Substrate Adhesion-dependent Cell Spreading Regulation Of Catalytic Activity Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Phosphorylation Activation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process
Tagcloud ?			apicomplexan bite borne coast deoxyhypusine dhs druggable ecf enormous genera guanyl heterocyclic hitherto hypusine infects invade malaria muguga orf plasmodium quinone rosetta saharan schizonts spacer sporozoites theileria tick transforms
Tagcloud (Difference) ?			apicomplexan bite borne coast deoxyhypusine dhs druggable ecf enormous genera guanyl heterocyclic hitherto hypusine infects invade malaria muguga orf plasmodium quinone rosetta saharan schizonts spacer sporozoites theileria tick transforms
Tagcloud (Intersection) ?