FBXO34 and COL8A1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FBXO34	COL8A1
Description		F-box protein 34	collagen type VIII alpha 1 chain
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Extracellular Region Collagen Trimer Collagen Type VIII Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Protein Binding	Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process		Angiogenesis Endothelial Cell Proliferation Cell Adhesion Positive Regulation Of Cell-substrate Adhesion Endodermal Cell Differentiation Camera-type Eye Morphogenesis
Pathways			Collagen degradation Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Collagen chain trimerization
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 32888494) Testicular germ cell tumor ( 28604728) Urate levels ( 31578528) White blood cell count ( 32888494)	A body shape index ( 34021172) Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 23455636 20385826) Axial length ( 24144296) Childhood ear infection ( 27182965) Hip index ( 34021172) Nonsyndromic cleft lip with cleft palate ( 28232668) Optic cup area ( 28073927 31798171 25631615) Optic disc area ( 28073927 31798171) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Superior frontal gyrus grey matter volume ( 25335168) Vertical cup-disc ratio ( 28073927 31798171 25241763) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		25 interacting genes: ALPP COL8A1 DISC1 FGF14 KRT40 KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-8 KRTAP12-4 KRTAP4-11 KRTAP4-12 KRTAP4-5 KRTAP5-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 MDFI MTUS2 OIT3 SKP1 SMAD4 TGFBR1 VHL VWC2L	78 interacting genes: ACTMAP ADAMTSL4 ARMC5 BPIFA1 C22orf39 CCN3 CEP55 CFAP68 CIDEB COL8A2 CREB5 CYSRT1 DPEP2NB EFEMP2 FAM86C1P FBLN2 FBXO34 FRS3 GLRX3 GSC2 HOXA1 INCA1 ITGA1 ITGA2 KLHL12 KLHL20 KPRP KRT37 KRT40 KRT82 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP12-3 KRTAP13-1 KRTAP13-3 KRTAP19-2 KRTAP19-5 KRTAP19-7 KRTAP26-1 KRTAP3-2 KRTAP4-12 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 LIMS1 MAJIN NADSYN1 NBPF19 NOTCH2NLA OTX1 PLSCR3 POF1B POU4F2 PPARA RBPMS REL RGS20 RHBDD2 SLC35A2 SP4 SPATA8 SPMIP6 SPRY4 SSC4D TRIM35 UBQLN2 UBQLN4 VAC14 WFDC5 YPEL3 ZNF774 ZNHIT1
Entrez ID		55030	1295
HPRD ID		16442	00372
Ensembl ID		ENSG00000178974	ENSG00000144810
Uniprot IDs		Q9NWN3	P27658
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Hair Cycle Positive Regulation Of Extracellular Matrix Assembly Endothelial Cell Activation Cytosol I-SMAD Binding Regulation Of Extracellular Matrix Assembly	Intermediate Filament Keratin Filament Identical Protein Binding Collagen Binding Involved In Cell-matrix Adhesion Cytosol Structural Constituent Of Skin Epidermis
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