PPM1G and MTNR1B

Number of citations of the paper that reports this interaction (PMID 17215244)
14

Data Source:
HPRD (in vivo)

		PPM1G	MTNR1B
Gene Name		protein phosphatase, Mg2+/Mn2+ dependent, 1G	melatonin receptor 1B
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding	G-protein Coupled Receptor Activity Protein Binding Melatonin Receptor Activity
	Biological Process	Protein Dephosphorylation Cell Cycle Arrest Peptidyl-threonine Dephosphorylation	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Synaptic Transmission Glucose Homeostasis Regulation Of Insulin Secretion
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Ramelteon Melatonin Agomelatine
Diseases
GWAS		Hypertriglyceridemia ( 23505323)	Adverse response to radiation therapy ( 23719583) Diabetes (gestational) ( 22233651) Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) Fasting plasma glucose ( 19060907 19060909 19651812 22508271) Glycated hemoglobin levels ( 20858683) Glycemic traits ( 23575436) Insomnia (caffeine-induced) ( 22754043) Metabolic syndrome ( 22399527) Metabolic traits ( 19060910) Metabolite levels ( 21909109 22286219) Obesity-related traits ( 23251661) Type 2 diabetes ( 20581827)
Protein-Protein Interactions		10 interactors: FBXO38 GRIA3 HIST3H3 LRPAP1 MSL1 MTNR1B RPS6KA1 TERF1 TERF2 TERF2IP	20 interactors: CANX COPA CTNND1 FLNA GNAI1 GNAI2 GNAI3 GNB1 GNB4 GPR50 HNRNPA0 HSPA5 IRS4 ITM2C MTNR1A PDIA6 PI4KA PPM1G VPS35 YWHAQ
Entrez ID		5496	4544
HPRD ID		09237	02882
Ensembl ID		ENSG00000115241	ENSG00000134640
Uniprot IDs		O15355 Q6IAU5	P49286
PDB IDs
Enriched GO Terms of Interacting Partners?		Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Telomere Maintenance Regulation Of Telomere Maintenance RNA-dependent DNA Replication Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomere Maintenance Via Telomere Lengthening Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Protection From Non-homologous End Joining At Telomere Telomere Capping Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Chromosome Organization Replicative Cell Aging Regulation Of Nuclear Cell Cycle DNA Replication Negative Regulation Of DNA Metabolic Process Chromosome Organization Regulation Of Chromosome Organization Protein Localization To Chromosome Homeostatic Process DNA Replication Negative Regulation Of DNA Replication Cell Aging Negative Regulation Of DNA Recombination At Telomere DNA Metabolic Process Positive Regulation Of Hepatic Stellate Cell Activation Regulation Of DNA Replication Negative Regulation Of Beta-amyloid Clearance Synaptic Transmission Chromatin Modification Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Chromatin Organization Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Beta-amyloid Clearance Organelle Organization Negative Regulation Of Telomerase Activity Positive Regulation Of Telomere Maintenance Regulation Of Cellular Component Organization Cell-cell Signaling Regulation Of Organelle Organization Regulation Of Telomere Maintenance Via Telomerase Histone H4-K16 Acetylation Positive Regulation Of Microtubule Polymerization Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Cellular Metabolic Process Regulation Of Telomerase Activity Regulation Of Translation In Response To Stress Aging Extracellular Negative Regulation Of Signal Transduction	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Platelet Activation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Blood Coagulation Hemostasis Signaling Cell Communication Substantia Nigra Development Signal Transduction Wound Healing Vesicle-mediated Transport Neural Nucleus Development Cell Activation Response To Wounding G-protein Coupled Receptor Signaling Pathway Midbrain Development G-protein Coupled Acetylcholine Receptor Signaling Pathway Cell-cell Signaling Cellular Response To Stimulus Synaptic Transmission Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Response To Stimulus Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of CAMP Metabolic Process Dopamine Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Response To Peptide Hormone Cellular Response To Glucagon Stimulus Negative Regulation Of Nucleotide Metabolic Process Membrane Organization Response To Peptide Vesicle Organization Vesicle Fusion Regulation Of Protein Folding In Endoplasmic Reticulum Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Response To Glucagon Positive Regulation Of Nuclease Activity Regulation Of Adenylate Cyclase Activity Regulation Of Signal Transduction Regulation Of Cellular Process Regulation Of Cyclase Activity Platelet Degranulation Secretion Cerebellum Structural Organization Negative Regulation Of Late Endosome To Lysosome Transport Organelle Fusion Cellular Response To Peptide Hormone Stimulus
Tagcloud ?			china cnki database electronic embase employed estimate gdm genetic gestational inclusion inconclusive infrastructure irs1 medline melatonin mellitus polymorphisms pubmed risks rs10830963 rs1387153 rs1801278 searched ten value variant variants
Tagcloud (Difference) ?			china cnki database electronic embase employed estimate gdm genetic gestational inclusion inconclusive infrastructure irs1 medline melatonin mellitus polymorphisms pubmed risks rs10830963 rs1387153 rs1801278 searched ten value variant variants
Tagcloud (Intersection) ?