PPM1G and RN7SK

Number of citations of the paper that reports this interaction (PubMedID 26324325)
63

Data Source:
BioGRID (pull down)

		PPM1G	RN7SK
Description		protein phosphatase, Mg2+/Mn2+ dependent 1G	RNA component of 7SK nuclear ribonucleoprotein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane	7SK SnRNP
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Cation Binding Metal Ion Binding
	Biological Process	Protein Dephosphorylation Signal Transduction Peptidyl-threonine Dephosphorylation Regulation Of Cell Cycle	Negative Regulation Of Transcription Elongation By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Bone mineral density (total hip) ( 29883787) Creatinine levels ( 31015462) Crohn's disease ( 28067908) Hypertriglyceridemia ( 23505323) Inflammatory bowel disease ( 28067908) Non-oily fish consumption ( 32066663) Takayasu arteritis ( 25604533) Triglyceride levels ( 31928498)	Staphylococcus aureus nasal carriage (intermittent) ( 26569114)
Interacting Genes		11 interacting genes: FBXO38 GRIA3 H3-4 HEXIM1 LRPAP1 MSL1 MTNR1B RN7SK RPS6KA1 TERF1 TERF2	7 interacting genes: CCNT1 CDK9 HEXIM1 HMGA1 LARP7 MEPCE PPM1G
Entrez ID		5496	125050
HPRD ID		09237
Ensembl ID		ENSG00000115241	ENSG00000202198
Uniprot IDs		O15355 Q6IAU5
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication 7SK SnRNP Shelterin Complex Telomerase Activity Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Transcription Elongation By RNA Polymerase II RNA-templated DNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription, Elongation Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Gamma-glutamyl Carboxylase Activity Negative Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Telomere Cap Complex Negative Regulation Of Telomere Maintenance Via Recombination Axonal Transport Of Messenger Ribonucleoprotein Complex Negative Regulation Of Telomere Single Strand Break Repair Vitamin Binding Negative Regulation Of Bone Development Chemical Synaptic Transmission Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Telomeric Loop Formation Negative Regulation Of DNA Recombination At Telomere Trans-synaptic Signaling Synaptic Signaling Regulation Of DNA Biosynthetic Process Amyloid-beta Binding DNA Biosynthetic Process Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Testosterone Biosynthetic Process Rough Endoplasmic Reticulum Lumen Negative Regulation Of T-circle Formation Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of DNA-templated Transcription Elongation	7SK SnRNA Binding SnRNA Binding 7SK SnRNP Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Negative Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of DNA-templated Transcription, Elongation P-TEFb Complex Positive Regulation Of SnRNA Transcription By RNA Polymerase II SnRNA Modification Cyclin/CDK Positive Transcription Elongation Factor Complex Positive Regulation Of Protein Localization To Cajal Body Negative Regulation Of Viral Transcription Host-mediated Activation Of Viral Transcription Regulation Of Viral Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Host-mediated Perturbation Of Viral Transcription Negative Regulation Of RNA Metabolic Process SnRNA Processing Host-mediated Activation Of Viral Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription SnRNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription, Elongation Host-mediated Perturbation Of Viral Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Negative Regulation Of Viral Process U6 2'-O-snRNA Methylation RNA 5'-gamma-phosphate Methyltransferase Activity RNA Methylation Positive Regulation Of Protein Localization Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Protein Localization To Nucleus Chromatin Binding Host-mediated Perturbation Of Symbiont Process Nucleoplasm Macromolecule Methylation Modulation Of Process Of Another Organism
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