RN7SK and MEPCE

Number of citations of the paper that reports this interaction (PubMedID 17643375)
69

Data Source:
BioGRID (enzymatic study)

		RN7SK	MEPCE
Description		RNA component of 7SK nuclear ribonucleoprotein	methylphosphate capping enzyme
Image		No pdb structure
GO Annotations	Cellular Component	7SK SnRNP	Nucleus 7SK SnRNP Ribonucleoprotein Complex
	Molecular Function		RNA Binding Protein Binding Methyltransferase Activity O-methyltransferase Activity RNA Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity Transferase Activity SnRNA Binding 7SK SnRNA Binding RNA 5'-gamma-phosphate Methyltransferase Activity
	Biological Process	Negative Regulation Of Transcription Elongation By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II RNA Methylation SnRNA Metabolic Process Methylation SnRNA Modification Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of SnRNA Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Staphylococcus aureus nasal carriage (intermittent) ( 26569114)	Brain morphology (MOSTest) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		7 interacting genes: CCNT1 CDK9 HEXIM1 HMGA1 LARP7 MEPCE PPM1G	2 interacting genes: ERBB2 RN7SK
Entrez ID		125050	56257
HPRD ID			07889
Ensembl ID		ENSG00000202198	ENSG00000146834
Uniprot IDs			Q7L2J0
PDB IDs			5UNA 6DCB 6DCC 7SLP 7SLQ
Enriched GO Terms of Interacting Partners?		7SK SnRNA Binding SnRNA Binding 7SK SnRNP Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Negative Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of DNA-templated Transcription, Elongation P-TEFb Complex Positive Regulation Of SnRNA Transcription By RNA Polymerase II SnRNA Modification Cyclin/CDK Positive Transcription Elongation Factor Complex Positive Regulation Of Protein Localization To Cajal Body Negative Regulation Of Viral Transcription Host-mediated Activation Of Viral Transcription Regulation Of Viral Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Host-mediated Perturbation Of Viral Transcription Negative Regulation Of RNA Metabolic Process SnRNA Processing Host-mediated Activation Of Viral Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription SnRNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription, Elongation Host-mediated Perturbation Of Viral Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Negative Regulation Of Viral Process U6 2'-O-snRNA Methylation RNA 5'-gamma-phosphate Methyltransferase Activity RNA Methylation Positive Regulation Of Protein Localization Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Protein Localization To Nucleus Chromatin Binding Host-mediated Perturbation Of Symbiont Process Nucleoplasm Macromolecule Methylation Modulation Of Process Of Another Organism	Negative Regulation Of Immature T Cell Proliferation In Thymus RNA Polymerase I Core Binding Positive Regulation Of Cell Growth ErbB-3 Class Receptor Binding ERBB3:ERBB2 Complex Immature T Cell Proliferation In Thymus ERBB2-ERBB4 Signaling Pathway Demethylase Activity DNA N6-methyladenine Demethylase Activity Midbody Broad Specificity Oxidative DNA Demethylase Activity Cleavage Furrow Ingression Protein Demethylase Activity Membrane Invagination Engulfment Of Target By Autophagosome 7SK SnRNP
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