TRNAU1AP and PRPF39

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid)

		TRNAU1AP	PRPF39
Description		tRNA selenocysteine 1 associated protein 1	pre-mRNA processing factor 39
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Commitment Complex Nucleus U1 SnRNP U2-type Prespliceosome
	Molecular Function	TRNA Binding Nucleic Acid Binding RNA Binding Protein Binding	Protein Binding Pre-mRNA 5'-splice Site Binding
	Biological Process	Selenocysteine Incorporation Translation	MRNA 5'-splice Site Recognition RNA Processing MRNA Processing RNA Splicing
Pathways
Drugs
Diseases
GWAS			Lead levels ( 26025379)
Interacting Genes		9 interacting genes: BCAS2 DMRTB1 GTSE1 PRPF39 PRRC2B QKI RBM42 SECISBP2 USP10	14 interacting genes: BANP CEBPA DHX30 DMRTB1 GTSE1 LARP4 MBNL1 PRRC2B QKI RBM22 RNU1-1 SF1 TOLLIP TRNAU1AP
Entrez ID		54952	55015
HPRD ID		18035	17913
Ensembl ID		ENSG00000180098	ENSG00000185246
Uniprot IDs		Q9NX07	Q86UA1
PDB IDs		2DHG 2DIV
Enriched GO Terms of Interacting Partners?		RNA Splicing Negative Regulation Of MRNA Metabolic Process MRNA Processing Stress Granule Assembly Nucleic Acid Metabolic Process RNA Splicing, Via Transesterification Reactions MRNA Metabolic Process MRNA Splicing, Via Spliceosome DNA Damage Response, Signal Transduction By P53 Class Mediator Membraneless Organelle Assembly RNA Metabolic Process Translational Elongation RNA Binding Regulation Of MRNA Metabolic Process MRNA Stabilization Internal N(7)-methylguanine-containing RNA Reader Activity Nucleobase-containing Compound Metabolic Process RNA Processing Negative Regulation Of MRNA Catabolic Process RNA Stabilization Negative Regulation Of Stress Granule Assembly Myofibroblast Contraction Negative Regulation Of RNA Catabolic Process Negative Regulation Of MiRNA Catabolic Process Signal Transduction By P53 Class Mediator Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing MRNA 3'-UTR Binding Spliceosome-depend Formation Of Circular RNA Pre-mRNA 5'-splice Site Binding Selenocysteine Insertion Sequence Binding Commitment Complex Signal Transduction In Response To DNA Damage Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Regulation Of RNA Splicing Regulation Of MRNA Stability Germ Cell Development Microglia Differentiation Negative Regulation Of Macrophage Differentiation Spliceosomal Complex MRNA 5'-splice Site Recognition Selenocysteine Incorporation Monoubiquitinated Protein Deubiquitination Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Vascular Associated Smooth Muscle Cell Differentiation Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Organelle Assembly Regulation Of RNA Stability Regulation Of Stress Granule Assembly Intracellular MRNA Localization	RNA Binding Nucleic Acid Binding Protein Localization To Endosome Cytoplasmic Stress Granule MRNA Cis Splicing, Via Spliceosome RNA Splicing Erythrocyte Apoptotic Process Macrophage Differentiation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding MRNA Processing Regulation Of RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Internal N(7)-methylguanine-containing RNA Reader Activity
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