LPCAT2 and HSD17B13

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LPCAT2	HSD17B13
Description		lysophosphatidylcholine acyltransferase 2	hydroxysteroid 17-beta dehydrogenase 13
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Golgi Stack Lipid Droplet Plasma Membrane Membrane Organelle Subcompartment	Cytoplasm Endoplasmic Reticulum Lipid Droplet Cytosol
	Molecular Function	1-acylglycerol-3-phosphate O-acyltransferase Activity Calcium Ion Binding Protein Binding O-acyltransferase Activity Transferase Activity Acyltransferase Activity Lysophosphatidic Acid Acyltransferase Activity Metal Ion Binding 2-acylglycerol-3-phosphate O-acyltransferase Activity Plasmalogen Synthase Activity 1-acylglycerophosphocholine O-acyltransferase Activity 1-alkylglycerophosphocholine O-acetyltransferase Activity	Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity All-trans-retinol Dehydrogenase (NAD+) Activity Protein Binding Steroid Dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor
	Biological Process	Lipid Metabolic Process Phospholipid Metabolic Process Glycerophospholipid Metabolic Process Platelet Activating Factor Biosynthetic Process Phospholipid Biosynthetic Process Phosphatidylcholine Acyl-chain Remodeling Membrane Organization	Lipid Metabolic Process Positive Regulation Of Lipid Biosynthetic Process
Pathways		Acyl chain remodelling of PC	Lipid particle organization
Drugs
Diseases
GWAS		Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Thyroid hormone levels ( 23408906)	Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Bulimia nervosa ( 23568457) Cirrhosis (alcohol related) ( 32853455) Cirrhosis (multi-trait analysis) ( 33310085) Liver enzyme levels (alanine transaminase) ( 22001757) Nonalcoholic steatohepatitis ( 32298765) Platelet count ( 22139419) Rosacea symptom severity ( 29771307) Triglyceride levels ( 31928498)
Interacting Genes		8 interacting genes: CREB3 EBP ERGIC3 HSD17B13 KCNJ6 RETREG3 RHBDD1 SLC71A2	129 interacting genes: ABHD16A ADGRE2 AGPAT3 AGPAT4 AGTRAP AIG1 ANKRD46 AOC3 APOA2 ARL6IP1 ATP6V0C BBC3 BMP10 BRICD5 C3orf52 CACNG1 CALHM6 CCDC167 CDIPT CLDN10 CLDN19 CLDN4 CLDND2 CMTM5 CMTM7 CYB5R3 CYBC1 CYP4F2 DIABLO EBP ECPAS FATE1 FAXDC2 FETUB GJB2 GOLM1 GOSR2 GYPB HSD3B7 IGFBP5 INSIG2 ITGAM JAGN1 LHFPL5 LPAR3 LPCAT2 LRAT MARCHF5 MGLL MIEF2 MMP14 MOSPD3 MS4A1 NAPB NAT8 NRM ORMDL3 PBX3 PLIN3 PLN PLP2 PNLIPRP1 PTPN9 RABAC1 REEP6 RHOU RPRM RUSF1 SACM1L SCAMP5 SCARF1 SCD SEC22B SERP1 SERP2 SFT2D2 SFXN1 SFXN2 SFXN3 SLC25A46 SLC30A3 SLC35B4 SLC35E4 SLC61A1 SMIM1 SNORC SPG21 ST6GAL2 STRIT1 STX5 STX7 TBRG4 TF THSD7A TIMM23 TIMMDC1 TMEM100 TMEM120A TMEM120B TMEM128 TMEM140 TMEM14B TMEM14C TMEM167B TMEM19 TMEM203 TMEM218 TMEM222 TMEM229B TMEM243 TMEM255B TMEM31 TMEM42 TMEM60 TMEM86B TMEM97 TMX2 TPRG1 TREX1 UBXN8 UNC50 VAMP2 VAMP3 VAMP4 VAMP5 VAPA VAPB YIPF2 YIPF4
Entrez ID		54947	345275
HPRD ID		07913	18023
Ensembl ID		ENSG00000087253	ENSG00000170509
Uniprot IDs		Q7L5N7	Q7Z5P4
PDB IDs			8G9V
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Endoplasmic Reticulum Membrane Response To Unfolded Protein Positive Regulation Of Deacetylase Activity C-8 Sterol Isomerase Activity Cholesterol-5,6-oxide Hydrolase Activity Cholestenol Delta-isomerase Activity Retrograde Transporter Complex, Golgi To ER Membrane Protein Proteolysis Involved In Retrograde Protein Transport, ER To Cytosol Cholesterol Biosynthetic Process Via Lathosterol Cholesterol Biosynthetic Process Via Desmosterol Steroid Delta-isomerase Activity Steroid Dehydrogenase Activity G-protein Activated Inward Rectifier Potassium Channel Activity Transporter Complex Endoplasmic Reticulum-autophagosome Adaptor Activity Release From Viral Latency Regulation Of Male Germ Cell Proliferation CCR1 Chemokine Receptor Binding Regulation Of Germ Cell Proliferation	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding SNAP Receptor Activity Serine Import Into Mitochondrion Endomembrane System SNARE Complex Monoatomic Ion Transmembrane Transporter Activity Lipid Biosynthetic Process Organelle Fusion Mitochondrial Transport Paracellular Transport Lipid Metabolic Process Vesicle-mediated Transport Glycerolipid Metabolic Process Membrane Fusion Import Into The Mitochondrion Golgi Membrane Acylglycerol Catabolic Process Golgi Vesicle Transport Serine Transport Lysophosphatidic Acid Acyltransferase Activity SNARE Complex Assembly CDP-diacylglycerol Metabolic Process Endoplasmic Reticulum Organization Vesicle Fusion Golgi Apparatus Transport Vesicle Vesicle Organization Organelle Membrane Fusion Golgi To Plasma Membrane Protein Transport FFAT Motif Binding Mitochondrial Outer Membrane Phospholipid Metabolic Process Phospholipid Biosynthetic Process 1-acylglycerol-3-phosphate O-acyltransferase Activity Sterol Biosynthetic Process Organelle Localization By Membrane Tethering Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum-Golgi Intermediate Compartment Acylglycerol Metabolic Process Sterol Metabolic Process Bounding Membrane Of Organelle Membrane Organization Neutral Lipid Metabolic Process Response To Endoplasmic Reticulum Stress Steroid Biosynthetic Process Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules
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