ADPRHL2 and HEXDC

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ADPRHL2	HEXDC
Gene Name		ADP-ribosylhydrolase like 2	hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Mitochondrial Matrix	Nucleus Cytoplasm
	Molecular Function	Poly(ADP-ribose) Glycohydrolase Activity Metal Ion Binding	Beta-N-acetylhexosaminidase Activity
	Biological Process	Metabolic Process Cellular Response To Superoxide	Carbohydrate Metabolic Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: FRA10AC1 HEXDC	9 interactors: ADPRHL2 C7orf25 EEF1D GDPD2 GLRX3 PARK2 PSD RILPL2 TUBB3
Entrez ID		54936	284004
HPRD ID		12432	08677
Ensembl ID		ENSG00000116863	ENSG00000169660
Uniprot IDs		B7ZAN4 Q9NX46	Q8WVB3
PDB IDs		2FOZ 2FP0 2G4K
Enriched GO Terms of Interacting Partners?			Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Mitochondrial Fusion Positive Regulation Of Protein Linear Polyubiquitination Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Dopamine Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Manganese Ion Protein K27-linked Ubiquitination Protein K29-linked Ubiquitination Negative Regulation Of Mitochondrial Fusion Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Fusion Negative Regulation Of Glucokinase Activity Neuron Cellular Homeostasis Positive Regulation Of Oxidative Stress-induced Cell Death Protein K6-linked Ubiquitination Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Mitochondrial Fission Regulation Of Mitochondrion Degradation Negative Regulation Of Cardiac Muscle Hypertrophy Dopamine Transport Negative Regulation Of Muscle Hypertrophy Aggresome Assembly Regulation Of Mitochondrial Fission Neurotransmitter Uptake Norepinephrine Metabolic Process Negative Regulation Of Actin Filament Bundle Assembly Synaptic Transmission, Dopaminergic Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Zinc Ion Homeostasis Negative Regulation Of Release Of Cytochrome C From Mitochondria Response To Manganese Ion Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Cellular Response To Ammonium Ion Cellular Response To Superoxide Regulation Of Dopamine Secretion Response To Oxidative Stress Cellular Response To Toxic Substance Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Monoamine Transport Mitochondrial Fission Cellular Response To Catecholamine Stimulus Negative Regulation Of Oxidative Stress-induced Cell Death Response To Superoxide Startle Response
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