ADPRS and PRDM5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ADPRS	PRDM5
Description		ADP-ribosylserine hydrolase	PR/SET domain 5
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Mitochondrion Mitochondrial Matrix Nuclear Body Site Of DNA Damage	Nucleus Nucleoplasm Nucleolus Nuclear Body
	Molecular Function	Magnesium Ion Binding Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Poly(ADP-ribose) Glycohydrolase Activity Protein Binding Hydrolase Activity Metal Ion Binding O-acetyl-ADP-ribose Deacetylase Activity ADP-ribosylserine Hydrolase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Sequence-specific DNA Binding Metal Ion Binding DNA-binding Transcription Factor Binding
	Biological Process	DNA Repair Base-excision Repair, Gap-filling DNA Damage Response Negative Regulation Of Necroptotic Process Cellular Response To Superoxide Peptidyl-serine ADP-deribosylation	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Chromatin Organization Methylation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Extracellular Matrix Organization Cellular Response To Leukemia Inhibitory Factor
Pathways		POLB-Dependent Long Patch Base Excision Repair
Drugs
Diseases
GWAS			F-cell distribution in sickle cell anaemia ( 21326311) Fasting plasma glucose ( 17903298) Hemoglobin levels ( 33491795) Loneliness (multivariate analysis) ( 27629369) Monobrow thickness ( 26926045) Obesity-related traits ( 23251661) Schizophrenia, bipolar disorder or recurrent major depressive disorder ( 34099189) Sensorimotor dexterity ( 31596458)
Interacting Genes		5 interacting genes: FRA10AC1 HEXD HSPB1 PRDM5 TNKS	7 interacting genes: ADPRS CLCN1 FAAP20 FBXO44 RASD1 TYK2 VIPR1
Entrez ID		54936	11107
HPRD ID		12432	17902
Ensembl ID		ENSG00000116863	ENSG00000138738
Uniprot IDs		B7ZAN4 Q9NX46	Q9NQX1
PDB IDs		2FOZ 2FP0 2G4K 5ZQY 6D36 6D3A 7AKR 7AKS 7ARW 7L9F 7L9H 7L9I	6XAZ
Enriched GO Terms of Interacting Partners?			ADP-ribosylserine Hydrolase Activity Cellular Response To Superoxide Peptidyl-serine ADP-deribosylation Interleukin-12 Receptor Complex Vasoactive Intestinal Polypeptide Receptor Activity Pituitary Adenylate Cyclase-activating Polypeptide Receptor Activity Poly(ADP-ribose) Glycohydrolase Activity Voltage-gated Chloride Channel Activity Interleukin-23-mediated Signaling Pathway Growth Hormone Receptor Binding Interleukin-10-mediated Signaling Pathway Receptor Complex Extrinsic Component Of Plasma Membrane Positive Regulation Of NK T Cell Proliferation Interleukin-12-mediated Signaling Pathway Interleukin-23 Receptor Complex Type III Interferon-mediated Signaling Pathway Positive Regulation Of NK T Cell Activation Response To Superoxide Response To Oxygen Radical Protein De-ADP-ribosylation O-acetyl-ADP-ribose Deacetylase Activity Ubiquitin-modified Protein Reader Activity Action Potential Propagation Neuronal Action Potential Propagation
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