KANSL2 and TTC3

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		KANSL2	TTC3
Description		KAT8 regulatory NSL complex subunit 2	tetratricopeptide repeat domain 3
Image			No pdb structure
GO Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleus Nucleoplasm Mitochondrion Cytosol Plasma Membrane Actin Cytoskeleton NSL Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol
	Molecular Function	Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Chromatin Organization Positive Regulation Of DNA-templated Transcription	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein K48-linked Ubiquitination
Pathways		HATs acetylate histones Formation of WDR5-containing histone-modifying complexes
Drugs
Diseases
GWAS		Clozapine-induced agranulocytosis ( 25187353) Letter-number span reordering ( 31596458)	Eye color traits ( 20463881)
Interacting Genes		4 interacting genes: APP IKBKG TSC1 TTC3	72 interacting genes: AKAP17A AKT1 APP ARID1A ATF7IP ATP2A2 ATP6V0A1 BLOC1S2 CADPS CADPS2 CEP290 CHUK CKAP2 CKAP5 COG4 COPS5 DAAM2 DLEU7 DSP DST EIF4G2 ETS2 EXOC4 FBXO7 FMNL2 FUT8 HARS1 HERC2 HSPB1 IFIT5 JADE2 JAK1 KANSL2 LCOR LRPAP1 MDH1 MIR7-1 MORF4L1 NR1D2 NR1H2 NUFIP1 PAX6 PBX2 PKNOX1 POLG PPFIBP1 PRKDC PSMD7 PSME1 RAI14 SH3BP5 SHROOM2 SMARCA4 SPARCL1 SPTAN1 SPTBN1 STXBP1 TAF1 THOP1 TJP1 TRAF6 TTN UBE2D2 UBE2E3 UBE3A UBR4 USP28 VHL WAC WHAMM XRN2 YWHAE
Entrez ID		54934	7267
HPRD ID		07907	03773
Ensembl ID		ENSG00000139620	ENSG00000182670
Uniprot IDs		Q9H9L4	H7BZ57 P53804
PDB IDs		4CY2
Enriched GO Terms of Interacting Partners?		Protein-folding Chaperone Binding Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Adult Locomotory Behavior Associative Learning Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress Memory T Cell Differentiation Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Cell Activation Involved In Immune Response Regulation Of Intrinsic Apoptotic Signaling Pathway Endosome To Plasma Membrane Transport Vesicle Adult Behavior Positive Regulation Of Endothelin Production Growth Cone Filopodium Protein-containing Complex Learning Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Locomotory Behavior Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization TSC1-TSC2 Complex Linear Polyubiquitin Binding Regulation Of Macroautophagy Positive Regulation Of Proteolysis Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Intracellular Signal Transduction Growth Factor Receptor Binding Main Axon ATPase Inhibitor Activity Immune Response Regulation Of Cell Junction Assembly Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity	Positive Regulation Of RNA Biosynthetic Process Protein-containing Complex Cytosol Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Protein Polyubiquitination Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Macromolecule Biosynthetic Process Protein Ubiquitination Post-translational Protein Modification Positive Regulation Of Biosynthetic Process Dense Core Granule Exocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle Establishment Of Vesicle Localization Protein K48-linked Ubiquitination Vesicle Localization Ubiquitin-protein Transferase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Calmodulin Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein K11-linked Ubiquitination Organelle Localization Toll-like Receptor 4 Signaling Pathway Regulation Of Autophagy Regulation Of Gene Expression Cell Surface Toll-like Receptor Signaling Pathway Regulation Of Cell Cycle Protein Modification Process Regulation Of Metabolic Process Enzyme Binding Intracellular Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Cadherin Binding Positive Regulation Of Macromolecule Metabolic Process Protein Localization To Cell-cell Junction Secretory Granule Localization Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Cellular Response To Stress Nucleoplasm Positive Regulation Of Protein Localization Regulation Of Cell Cycle Phase Transition Cell Cortex Regulation Of RNA Metabolic Process Golgi To Plasma Membrane Transport Ubiquitin-dependent Protein Catabolic Process Proteasome Complex
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