ELP6 and ELP1

Number of citations: 102 (PubMedID 36617428)
Data Source: BioGRID (pull down)

		ELP6	ELP1
Name		elongator acetyltransferase complex subunit 6	elongator acetyltransferase complex subunit 1
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Elongator Holoenzyme Complex	Nucleus Cytoplasm Cytosol Elongator Holoenzyme Complex
	Molecular Function	Protein Binding	TRNA Binding Protein Binding
	Biological Process	TRNA Wobble Uridine Modification Translation Regulation Of Translation Protein Folding Autophagy Apoptotic Process Response To Unfolded Protein Locomotory Behavior TRNA Processing Ubiquitin Recycling Positive Regulation Of Cell Migration Cellular Response To Stress Photoreceptor Cell Differentiation Homeostasis Of Number Of Retina Cells Neuromuscular Process Controlling Balance Neuromuscular Process Neuron Apoptotic Process Retina Development In Camera-type Eye Motor Behavior Autophagosome Maturation Inflammasome-mediated Signaling Pathway	TRNA Wobble Uridine Modification TRNA Wobble Base 5-methoxycarbonylmethyl-2-thiouridinylation Regulation Of Translation TRNA Processing
Pathways		HATs acetylate histones	HATs acetylate histones
GWAS		Refractive error ( 32231278 )	Appendicular lean mass ( 33097823 )
Novel Interactors		1 novel interactors: QRICH1	None recorded
Interacting Genes		7 interacting genes: CLK1 ELP1 ELP2 ELP3 ELP4 MLH1 SRPK2	27 interacting genes: BAG6 BARD1 CCT5 CDKN2B CHUK CSTF2 ELP2 ELP3 ELP6 HTT IKBKB IRF4 MAN2A2 MAP3K14 MAP3K7 MAPK8 MRPL42 NDUFB9 NFKBIA NIPSNAP3A PBX2 PLP2 SDHAF2 SNAPIN TAC3 TTR TXNDC9
Entrez ID		54859	8518
HPRD ID		07884	04763
Ensembl ID		ENSG00000163832	ENSG00000070061
Uniprot IDs		C9IYN7 Q0PNE2	A0A6Q8PGW3 A0A6Q8PHA0 B3KNB2 B4E3I9 F5H2T0 O95163 Q8N516
PDB IDs		Not available	5CQR 8PTX 8PTY 8PTZ 8PU0
GO Terms Enriched among Interactors		Elongator Holoenzyme Complex TRNA Wobble Uridine Modification TRNA Modification TRNA Processing RNA Modification TRNA Wobble Base 5-methoxycarbonylmethyl-2-thiouridinylation Phosphorylase Kinase Regulator Activity TRNA Metabolic Process RNA Metabolic Process RNA Processing Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Transcription Elongation Factor Complex Regulation Of Primary Metabolic Process Nucleic Acid Metabolic Process Post-transcriptional Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleus Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment TRNA Uridine(34) Acetyltransferase Activity TRNA Binding Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Chiasma Male Meiosis Chromosome Segregation MutLalpha Complex Guanine/thymine Mispair Binding Negative Regulation Of Mitotic Recombination Nuclear Speck Organization Regulation Of Nucleobase-containing Compound Metabolic Process Homologous Chromosome Segregation Female Meiosis Chromosome Segregation Mismatch Repair Complex Positive Regulation Of Isotype Switching To IgA Isotypes Intrinsic Apoptotic Signaling Pathway Regulation Of RNA Splicing MutSalpha Complex Binding Regulation Of Mitotic Recombination Regulation Of Protein Metabolic Process Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Telomere Localization R-loop Processing Mismatched DNA Binding Positive Regulation Of Isotype Switching To IgG Isotypes PERK-mediated Unfolded Protein Response	Non-canonical NF-kappaB Signal Transduction Elongator Holoenzyme Complex TRNA Wobble Uridine Modification Immune Response-regulating Signaling Pathway Canonical NF-kappaB Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway IkappaB Kinase Activity Fc-epsilon Receptor Signaling Pathway Stress-activated MAPK Cascade Innate Immune Response-activating Signaling Pathway Stress-activated Protein Kinase Signaling Cascade Interleukin-1-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor Activation Of Innate Immune Response Immune Response-activating Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway Signal Transduction Involved In Regulation Of Gene Expression Response To Tumor Necrosis Factor Immune Response-activating Cell Surface Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Activation Of Immune Response Cell Surface Toll-like Receptor Signaling Pathway IkappaB Kinase Complex Negative Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Innate Immune Response Regulation Of Immune Response Cell Surface Pattern Recognition Receptor Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Tumor Necrosis Factor-mediated Signaling Pathway CD40 Receptor Complex Transferrin Receptor Binding TRIF-dependent Toll-like Receptor Signaling Pathway Cytosol Scaffold Protein Binding MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MAP Kinase Activity Regulation Of Cytokine Production Involved In Inflammatory Response TRNA Modification Protein Serine/threonine Kinase Activity Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Immune Response Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway