XAF1 and RNF114

Number of citations of the paper that reports this interaction (PMID 25313037)
0

Data Source:
BioGRID (pull down)

		XAF1	RNF114
Gene Name		XIAP associated factor 1	ring finger protein 114
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Cytosol	Intracellular Nucleus Cytoplasm
	Molecular Function	Zinc Ion Binding	Zinc Ion Binding Ligase Activity
	Biological Process	Apoptotic Process Cytokine-mediated Signaling Pathway Negative Regulation Of Protein Complex Assembly Response To Interferon-beta Type I Interferon Signaling Pathway	Multicellular Organismal Development Spermatogenesis Protein Ubiquitination Cell Differentiation
Pathways		Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling
Drugs
Diseases
GWAS			Psoriasis ( 20953189)
Protein-Protein Interactions		5 interactors: APP CREBBP RNF114 TP53 XIAP	26 interactors: AK5 BMI1 EVI2A MAPK3 RNF38 RPSA TRAF4 TRAF6 TRAIP TRIM52 TRIM55 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2DNL UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2K UBE2U UBE2W UEVLD XAF1
Entrez ID		54739	55905
HPRD ID		06978	10329
Ensembl ID		ENSG00000132530	ENSG00000124226
Uniprot IDs		B3KPW1 Q6GPH4	Q9Y508
PDB IDs		2LXW
Enriched GO Terms of Interacting Partners?		Notch Signaling Pathway Copper Ion Homeostasis Negative Regulation Of Hydrolase Activity Neuron Apoptotic Process Neuron Death Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Negative Regulation Of Cell Differentiation Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Catalytic Activity Transition Metal Ion Homeostasis Negative Regulation Of Macromitophagy Synaptic Growth At Neuromuscular Junction Positive Regulation Of Protein Linear Polyubiquitination Oligodendrocyte Apoptotic Process Negative Regulation Of Helicase Activity N-terminal Peptidyl-lysine Acetylation Collateral Sprouting In Absence Of Injury Intrinsic Apoptotic Signaling Pathway Apoptotic Process Positive Regulation Of Cellular Metabolic Process Programmed Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Peptidyl-tyrosine Phosphorylation Cell Death Death Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Signal Transduction Response To Abiotic Stimulus Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cellular Protein Metabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Germ-line Stem Cell Maintenance Positive Regulation Of Thymocyte Apoptotic Process Positive Regulation Of Cell Aging Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Endopeptidase Activity Positive Regulation Of Protein Metabolic Process Negative Regulation Of Peptidase Activity Regulation Of Signaling Mitochondrial DNA Repair Axon Choice Point Recognition Positive Regulation Of Cell Cycle Cell Surface Receptor Signaling Pathway Negative Regulation Of Neurogenesis Immune Response Response To Hypoxia	Protein Ubiquitination Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Cellular Protein Modification Process Cellular Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Toll-like Receptor Signaling Pathway Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein Catabolic Process Activation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Innate Immune Response Protein K63-linked Ubiquitination Regulation Of Innate Immune Response Positive Regulation Of Protein Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Transferase Activity Positive Regulation Of Ligase Activity Cellular Response To Stress Proteolysis Regulation Of Protein Ubiquitination Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Apoptotic Process Cellular Response To Oxygen Levels Programmed Cell Death Histone Ubiquitination Catabolic Process Immune Response-regulating Signaling Pathway Cell Death Death Protein Monoubiquitination Innate Immune Response
Tagcloud ?		adding complexity decisions determines e3 fail fate favoring feedback finger hipk2 homeodomain inactivated interferes ligase loop preferentially proline siah2 stimulates switch termination ubiquitin ubiquitination uncovers waf1 xiap zinc znf313
Tagcloud (Difference) ?		adding complexity decisions determines e3 fail fate favoring feedback finger hipk2 homeodomain inactivated interferes ligase loop preferentially proline siah2 stimulates switch termination ubiquitin ubiquitination uncovers waf1 xiap zinc znf313
Tagcloud (Intersection) ?